Gene: BIN1

274
AMPH2|AMPHL|CNM2|SH3P9
bridging integrator 1
protein-coding
2q14.3
Ensembl:ENSG00000136717 MIM:601248 Vega:OTTHUMG00000131465 UniprotKB:O00499
NG_012042.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.360e-1 (AD)  5.924e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1137845chr2:127063631 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04019522chr2:127852450BIN11.500e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM50A0.911
PRKCSH0.908
GTF3C50.894
GPS20.891
APLP10.886
PAF10.883
RALY0.882
TBCB0.88
TALDO10.878
SIRT20.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.741
OR4F5-0.727
PDE3A-0.22
HCAR1-0.214
KCNK5-0.211
NKAIN3-0.207
MTRNR2L9-0.203
MTRNR2L10-0.2
NR2F2-AS1-0.199
FREM2-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of BIN1 protein"21673325
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BIN1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of BIN1 mRNA"20206263
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one[5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in decreased activity of MYC protein] which results in increased expression of BIN1 protein21447800
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one[5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in decreased expression of MYC protein] promotes the reaction [ZBTB17 protein binds to BIN1 promoter]21447800
D000082AcetaminophenAcetaminophen results in increased expression of BIN1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of BIN1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of BIN1 mRNA28959563
C000188alachloralachlor results in increased expression of BIN1 mRNA12419858
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BIN1 mRNA16483693
D001241AspirinAspirin results in increased expression of BIN1 mRNA12800193
D001280AtrazineAtrazine results in increased expression of BIN1 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of BIN1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BIN1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BIN1 mRNA19770486|2171566
D004958EstradiolEstradiol affects the expression of BIN1 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of BIN1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of BIN1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of BIN1 mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of BIN1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of BIN1 mRNA17659339
D020148Butyric AcidButyric Acid results in increased expression of BIN1 mRNA12800193
D002104CadmiumCadmium results in increased expression of BIN1 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BIN1 protein24527689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BIN1 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of BIN1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of BIN1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of BIN1 mRNA19770486
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of BIN1 protein23352502
D003976DiazinonDiazinon affects the expression of BIN1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BIN1 mRNA21266533
D002945Cisplatin[BIN1 protein results in decreased activity of PARP1 protein] which results in increased susceptibility to Cisplatin21447800
D002945CisplatinBIN1 protein results in increased susceptibility to Cisplatin21447800
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of BIN1 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BIN1 mRNA26924002
D004026DieldrinDieldrin affects the expression of BIN1 mRNA22546817
C024629dimethyl phthalatedimethyl phthalate affects the expression of BIN1 mRNA26924002
D004317Doxorubicin[BIN1 protein binds to and results in decreased activity of MYC protein] which results in increased susceptibility to Doxorubicin21447800
D004317DoxorubicinBIN1 protein results in increased susceptibility to Doxorubicin21447800
D000431EthanolEthanol results in increased expression of BIN1 protein20621659
D000431EthanolEthanol affects the expression of BIN1 mRNA26730594
D005047EtoposideBIN1 protein results in increased susceptibility to Etoposide21447800
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BIN1 gene20938992
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of BIN1 mRNA21782745
D019833GenisteinGenistein results in decreased expression of BIN1 mRNA21782745
D005839GentamicinsGentamicins results in increased expression of BIN1 mRNA22061828
D006861Hydrogen Peroxide[BIN1 protein binds to PARP1 protein] inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]21447800
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BIN1 mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of BIN1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of BIN1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BIN1 mRNA23086925|2479639
D018021Lithium ChlorideLithium Chloride results in increased expression of BIN1 mRNA19410610
D008694MethamphetamineMethamphetamine results in decreased expression of BIN1 protein19826936
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BIN1 gene20938992
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of BIN1 mRNA21782745
D008731MethoxychlorMethoxychlor results in decreased expression of BIN1 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of BIN1 mRNA23103053
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BIN1 mRNA26924002
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of BIN1 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of BIN1 mRNA22714537
D017239PaclitaxelPaclitaxel results in increased expression of BIN1 mRNA19682730
D010269ParaquatParaquat affects the splicing of BIN1 mRNA23613995
D010634PhenobarbitalPhenobarbital results in decreased expression of BIN1 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of BIN1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of BIN1 mRNA18037150
D011441PropylthiouracilPropylthiouracil results in decreased expression of BIN1 mRNA24780913
C502851quinocetonequinocetone results in decreased expression of BIN1 mRNA27046791
D012643SeleniumSelenium results in increased expression of BIN1 mRNA19244175
D012906SmokeSmoke results in increased expression of BIN1 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of BIN1 mRNA22714537
C016104sodium bichromatesodium bichromate results in increased expression of BIN1 mRNA12325037
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BIN1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BIN1 mRNA22298810
D014212TretinoinTretinoin results in increased expression of BIN1 mRNA23830798
C012589trichostatin Atrichostatin A results in decreased expression of BIN1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of BIN1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of BIN1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of BIN1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BIN1 gene25560391
D014810Vitamin EVitamin E results in increased expression of BIN1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI27179792  
GO:0005515protein binding-IPI10903846  12604805  12668730  12972505  16275660  16530520  
18647389  18985028  19004523  23399914  23917616  24169621  
26506308  
GO:0030276clathrin binding-TAS25051234  
GO:0042802identical protein binding-IPI23917616  
GO:0048156tau protein binding-IPI23399914  25051234  
GO:0051015actin filament binding-IDA26506308  
GO:0051087chaperone binding-IPI25051234  
GO:0070063RNA polymerase binding-IPI16530520  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-TAS23399914  25051234  
GO:0006997nucleus organization-IMP26506308  
GO:0007010cytoskeleton organization-TAS23399914  
GO:0008283cell proliferation-TAS8782822  
GO:0008333endosome to lysosome transport-IMP27179792  
GO:0016032viral process-IEA-  
GO:0030100regulation of endocytosis-IEA-  
GO:0030838positive regulation of actin filament polymerization-ISS-  
GO:0033292T-tubule organization-ISS-  
GO:0043065positive regulation of apoptotic process-IDA16530520  
GO:0043065positive regulation of apoptotic process-IMP10412034  
GO:0045664regulation of neuron differentiation-IMP10412034  
GO:0048711positive regulation of astrocyte differentiation-IMP10412034  
GO:0051647nucleus localization-IEA-  
GO:0060988lipid tube assembly-IMP19004523  
GO:0061024membrane organization-TAS-  
GO:0071156regulation of cell cycle arrest-IDA10412034  
GO:0086091regulation of heart rate by cardiac conduction-ISS-  
GO:1901380negative regulation of potassium ion transmembrane transport-ISS-  
GO:1902430negative regulation of amyloid-beta formation-IMP27179792  
GO:1902960negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IMP27179792  
GO:1903946negative regulation of ventricular cardiac muscle cell action potential-ISS-  
GO:1904878negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA25051234  
GO:0005635nuclear envelope-IEA-  
GO:0005737cytoplasm-IDA25051234  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeletoncolocalizes_withIDA25051234  
GO:0015629actin cytoskeleton-TAS9182667  
GO:0016020membrane-IDA16530520  25051234  
GO:0016020membrane-TAS28755476  
GO:0030018Z disc-ISS-  
GO:0030315T-tubule-ISS-  
GO:0030424axon-IDA23399914  
GO:0031674I band-ISS-  
GO:0033268node of Ranvier-ISS-  
GO:0043194axon initial segment-ISS-  
GO:0060987lipid tube-IMP19004523  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget