Gene: GLRA1

2741
HKPX1|STHE
glycine receptor alpha 1
protein-coding
5q33.1
Ensembl:ENSG00000145888 MIM:138491 Vega:OTTHUMG00000130121 UniprotKB:P23415
NG_011764.1
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.542e-1 (AD)  4.641e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAMTS20.512
GOLGA8S0.509
LANCL30.477
PROX20.47
NEUROG30.458
HTR1A0.45
SPATA170.45
HSD11B20.449
CT620.446
KCNH60.445

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HOXA4-0.325
DOK2-0.282
HRC-0.275
KLRK1-0.262
LGALS2-0.258
COX4I2-0.253
GZMB-0.247
FZD10-0.243
IFIT1B-0.242
FASLG-0.239

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00431LindaneSmall Molecule58-89-9Approved|WithdrawnTarget
DB00466PicrotoxinSmall Molecule124-87-8ExperimentalTarget
DB00572AtropineSmall Molecule51-55-8ApprovedTarget
DB00753IsofluraneSmall Molecule26675-46-7ApprovedTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01028MethoxyfluraneSmall Molecule76-38-0Approved|InvestigationalTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
DB01189DesfluraneSmall Molecule57041-67-5ApprovedTarget
DB01236SevofluraneSmall Molecule28523-86-6ApprovedTarget
DB01381Ginkgo bilobaSmall Molecule-Approved|Investigational|NutraceuticalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
DB03929D-SerineSmall Molecule312-84-5Approved|Experimental|InvestigationalTarget
DB05417GW 468816Small Molecule-InvestigationalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB11582ThiocolchicosideSmall Molecule602-41-5Approved|InvestigationalTarget
DB00228EnfluraneSmall Molecule13838-16-9Approved|InvestigationalTarget
DB05885SeletracetamSmall Molecule357336-74-4InvestigationalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein mutant form]"10825391
C0245661,1,1-trichloroethane"GLRA1 protein results in increased susceptibility to 1,1,1-trichloroethane"10825391
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLRA1 mRNA"19114083
C0913783-(2'-phosphonomethyl(1,1'-biphenyl)-3-yl)alanine"3-(2'-phosphonomethyl(1,1'-biphenyl)-3-yl)alanine binds to and results in decreased activity of GLRA1 protein"15081878
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GLRA1 mRNA"18648102
D000079AcetaldehydeAcetaldehyde results in increased activity of GLRA1 protein11707631
D000082AcetaminophenAcetaminophen affects the expression of GLRA1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLRA1 gene27153756
C015001arsenitearsenite results in increased methylation of GLRA1 promoter23974009
D001285AtropineAtropine binds to and results in decreased activity of GLRA1 protein15081878
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GLRA1 mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of GLRA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GLRA1 gene28505145
C083806brucinebrucine analog binds to and results in decreased activity of GLRA1 protein16687139
C083806brucinebrucine binds to and results in decreased activity of GLRA1 protein15081878|1668713
D000440ButanolsButanols promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D002104CadmiumCadmium results in increased expression of GLRA1 mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GLRA1 mRNA21362169
D002697Chloral HydrateChloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D002724ChlorobutanolChlorobutanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D003300CopperCopper results in decreased activity of GLRA1 protein16842826
D003300CopperGLRA1 protein binds to Copper16842826
D003300CopperGLRA1 protein mutant form results in decreased susceptibility to Copper16842826
D003471CuprizoneCuprizone affects the expression of GLRA1 mRNA27523638
D003471CuprizoneCuprizone results in decreased expression of GLRA1 mRNA26577399
D004077DigoxinABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]25419811
C084101doramectinABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA]25419811
D004737EnfluraneEnflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198|1082539
D000431EthanolEthanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10825391
D004986EtherEther promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GLRA1 mRNA20227414
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GLRA1 exon16964444
C082360fipronilfipronil results in decreased activity of GLRA1 protein22035056
D019833GenisteinGenistein results in decreased activity of GLRA1 protein20719748
D019833GenisteinStrychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]20719748
D019833GenisteinGenistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]20719748
D019833GenisteinGenistein results in increased expression of GLRA1 mRNA21782745
D018684Glycine Agents"1,1,1-trichloroethane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein mutant form]"10825391
D018684Glycine AgentsButanols promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D018684Glycine AgentsChloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine AgentsChlorobutanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine AgentsEnflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198|1082539
D018684Glycine AgentsEthanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10825391
D018684Glycine AgentsEther promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine AgentsGlycine Agents binds to and affects the activity of GLRA1 protein mutant form11049924
D018684Glycine AgentsGlycine Agents binds to and results in decreased activity of GLRA1 protein11049924
D018684Glycine AgentsGlycine Agents results in increased activity of GLRA1 protein10683198|1082539
D018684Glycine AgentsIsoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine AgentsMethoxyflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine Agentsn-butyl mercaptan promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D018684Glycine Agentspropanethiol promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D018684Glycine AgentsPropanols promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D018684Glycine Agentssevoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine Agentstert-Butyl Alcohol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine AgentsToluene affects the reaction [Glycine Agents results in increased activity of GLRA1 protein mutant form]10825391
D018684Glycine AgentsToluene promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10825391
D018684Glycine Agentstribromoethanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D018684Glycine AgentsTrichloroethylene affects the reaction [Glycine Agents results in increased activity of GLRA1 protein mutant form]10825391
D018684Glycine AgentsTrichloroethylene promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10825391
D018684Glycine AgentsTrifluoroethanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D007530IsofluraneIsoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D007559IvermectinABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]25419811
D007559IvermectinIvermectin results in increased activity of GLRA1 protein mutant form25231486
C045463leflunomideleflunomide results in increased expression of GLRA1 mRNA28988120
D001556LindaneLindane results in decreased activity of GLRA1 protein22035056
D008733MethoxyfluraneMethoxyflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate affects the expression of GLRA1 mRNA28349193
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GLRA1 mRNA26011545
C027837milbemycinABCB1 gene mutant form affects the reaction [milbemycin affects the expression of GLRA1 mRNA]25419811
C025540n-butyl mercaptann-butyl mercaptan promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
C031181phenanthrenephenanthrene results in increased expression of GLRA1 mRNA21362169
D010852PicrotoxinPicrotoxin binds to and results in decreased activity of GLRA1 protein15081878
C018370pregnenolone sulfatepregnenolone sulfate results in decreased activity of GLRA1 protein15081878
C030762propanethiolpropanethiol promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D020005PropanolsPropanols promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]11049924
D011441PropylthiouracilPropylthiouracil results in decreased expression of GLRA1 mRNA24780913
D011794QuercetinQuercetin results in decreased activity of GLRA1 protein20719748
D011794QuercetinStrychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]20719748
D011794QuercetinQuercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]20719748
C032061RU 5135RU 5135 binds to and results in decreased activity of GLRA1 protein15081878
D012524SarinSarin results in increased expression of GLRA1 mRNA19522546
C009250sevofluranesevoflurane promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D013331StrychnineStrychnine analog binds to and results in decreased activity of GLRA1 protein16687139
D013331StrychnineStrychnine binds to and results in decreased activity of GLRA1 protein15081878|1668713
D013331StrychnineStrychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]20719748
D013331StrychnineStrychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]20719748
D013331StrychnineStrychnine results in decreased activity of GLRA1 protein20719748
D013331StrychnineGenistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]20719748
D013331StrychnineQuercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]20719748
D013331StrychnineStrychnine results in decreased activity of GLRA1 protein20719748
D013331StrychnineStrychnine results in decreased activity of GLRA1 protein7752562
D013654TaurineTaurine binds to and results in increased activity of GLRA1 protein15081878
D020002tert-Butyl Alcoholtert-Butyl Alcohol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLRA1 mRNA21570461
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased activity of GLRA1 protein7752562
D013792ThalidomideThalidomide results in increased expression of GLRA1 mRNA28892372
D014050TolueneGLRA1 protein results in increased susceptibility to Toluene10825391
D014050TolueneToluene affects the reaction [Glycine Agents results in increased activity of GLRA1 protein mutant form]10825391
D014050TolueneToluene promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10825391
C062527tribromoethanoltribromoethanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D014241TrichloroethyleneGLRA1 protein mutant form affects the susceptibility to Trichloroethylene10825391
D014241TrichloroethyleneGLRA1 protein results in increased susceptibility to Trichloroethylene10825391
D014241TrichloroethyleneTrichloroethylene affects the reaction [Glycine Agents results in increased activity of GLRA1 protein mutant form]10825391
D014241TrichloroethyleneTrichloroethylene promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10825391
D014270TrifluoroethanolTrifluoroethanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]10683198
D014635Valproic AcidValproic Acid results in decreased methylation of GLRA1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GLRA1 mRNA24896083
D015032ZincGLRA1 protein binds to Zinc16842826
D015032ZincGLRA1 protein mutant form results in decreased susceptibility to Zinc16842826
D015032ZincZinc results in decreased activity of GLRA1 protein15081878
D015032ZincGLRA1 protein affects the susceptibility to Zinc17114051
D015032ZincZinc results in increased activity of GLRA1 protein17114051
D015032ZincZinc results in increased activity of GLRA1 protein7752562

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005254chloride channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI11929858  
GO:0008270zinc ion binding-IMP16144831  
GO:0016594glycine bindingCONTRIBUTES_TOIBA21873635  
GO:0016594glycine binding-IDA2155780  7920629  8717357  15748848  
GO:0016934extracellularly glycine-gated chloride channel activityCONTRIBUTES_TOIBA21873635  
GO:0016934extracellularly glycine-gated chloride channel activity-IDA2155780  8137830  16144831  
GO:0016934extracellularly glycine-gated chloride channel activitycontributes_toIGI8717357  
GO:0016934extracellularly glycine-gated chloride channel activity-IMP7920629  
GO:0022824transmitter-gated ion channel activity-IEA-  
GO:0030977taurine binding-IDA15748848  
GO ID GO Term Qualifier Evidence PubMed
GO:0001508action potential-IEA-  
GO:0001964startle response-IMP8298642  11973623  
GO:0002087regulation of respiratory gaseous exchange by neurological system process-IEA-  
GO:0006811ion transport-IDA2155780  
GO:0006821chloride transport-IDA8137830  
GO:0006936muscle contraction-IMP11973623  
GO:0007165signal transduction-IBA21873635  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-IDA2155780  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007340acrosome reaction-IEA-  
GO:0007601visual perception-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0042391regulation of membrane potential-IMP7920629  
GO:0043200response to amino acid-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0050884neuromuscular process controlling posture-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0051291protein heterooligomerization-IEA-  
GO:0051970negative regulation of transmission of nerve impulse-IMP11973623  
GO:0060012synaptic transmission, glycinergic-IBA21873635  
GO:0060012synaptic transmission, glycinergic-ISS-  
GO:0060013righting reflex-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060080inhibitory postsynaptic potential-ISS-  
GO:0071230cellular response to amino acid stimulus-IDA16144831  
GO:0071294cellular response to zinc ion-IDA16144831  
GO:0071361cellular response to ethanol-IDA25973519  
GO:0097305response to alcohol-ISS-  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IDA16144831  
GO:2000344positive regulation of acrosome reaction-IMP11751269  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA2155780  7506679  16144831  
GO:0005887integral component of plasma membrane-IMP11973623  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-NAS15952785  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0043204perikaryon-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA7506679  
GO:0045202synapse-IBA21873635  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:0060077inhibitory synapse-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24845178Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. (2014 Jul)Levran OPsychoneuroendocrinology