Gene: GLRA2

2742
GLR
glycine receptor alpha 2
protein-coding
Xp22.2
Ensembl:ENSG00000101958 MIM:305990 Vega:OTTHUMG00000021166 UniprotKB:P23416
NG_016459.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FSTL50.901
ZCCHC120.862
ROBO20.838
COL25A10.836
HS6ST20.836
TENM10.83
RAB3C0.829
GRIP10.829
GAD20.829
PEG30.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANPEP-0.52
CSAG1-0.512
MAGEA12-0.502
INHBB-0.494
RHOJ-0.492
CDA-0.49
NBPF10-0.489
SYDE1-0.487
TCF7-0.486
RGL3-0.479

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
DB00431LindaneSmall Molecule58-89-9Approved|WithdrawnTarget
DB00466PicrotoxinSmall Molecule124-87-8ExperimentalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB01956TaurineSmall Molecule107-35-7Approved|NutraceuticalTarget
ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of GLRA2 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GLRA2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GLRA2 mRNA16483693
C006780bisphenol Abisphenol A results in increased expression of GLRA2 mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GLRA2 mRNA18668222
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GLRA2 mRNA23914054
D000431EthanolEthanol results in decreased expression of GLRA2 mRNA20655511
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of GLRA2 mRNA17347304
C540355fenamidonefenamidone results in decreased expression of GLRA2 mRNA27029645
C082360fipronilfipronil results in decreased activity of GLRA2 protein22035056
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of GLRA2 mRNA17347304
C008261lead acetatelead acetate results in decreased expression of GLRA2 mRNA22613225
C008261lead acetatelead acetate results in decreased expression of GLRA2 mRNA22641619
D001556LindaneLindane results in decreased activity of GLRA2 protein22035056
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GLRA2 mRNA23103053
D015741MetriboloneMetribolone results in decreased expression of GLRA2 mRNA17010675
D009020MorphineMorphine results in increased expression of GLRA2 mRNA21178816
D011441PropylthiouracilPropylthiouracil affects the expression of GLRA2 mRNA24780913
C017947sodium arsenitesodium arsenite results in increased methylation of GLRA2 gene24570342
D012999SomanSoman results in decreased expression of GLRA2 mRNA19281266
D013331StrychnineStrychnine results in decreased activity of GLRA2 protein7752562
D014635Valproic AcidValproic Acid results in decreased expression of GLRA2 mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005254chloride channel activityCONTRIBUTES_TOIBA21873635  
GO:0016594glycine bindingCONTRIBUTES_TOIBA21873635  
GO:0016594glycine binding-IDA2155780  
GO:0016934extracellularly glycine-gated chloride channel activityCONTRIBUTES_TOIBA21873635  
GO:0016934extracellularly glycine-gated chloride channel activity-IDA2155780  
GO:0022852glycine-gated chloride ion channel activity-IDA23895467  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-IDA2155780  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IDA2155780  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0043200response to amino acid-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO:0060012synaptic transmission, glycinergic-IBA21873635  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0071230cellular response to amino acid stimulus-IDA2155780  
GO:0071294cellular response to zinc ion-IDA23895467  
GO:0071361cellular response to ethanol-IDA23895467  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IDA23895467  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA2155780  23895467  
GO:0030054cell junction-IEA-  
GO:0034707chloride channel complex-IEA-  
GO:0042995cell projection-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11409700Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases. (2001 Mar)Feng JPsychiatr Genet