Gene: HTRA2

27429
MGCA8|OMI|PARK13|PRSS25
HtrA serine peptidase 2
protein-coding
2p13.1
Ensembl:ENSG00000115317 MIM:606441 Vega:OTTHUMG00000129957 UniprotKB:O43464
NG_012163.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.986e-2 (AD)  2.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD80.951
ASNA10.948
MRPL370.945
MRPS70.941
CHMP70.939
TMEM2030.939
PSMD20.939
PNMA10.938
DCTN20.938
MTCH10.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.716
OR4F29-0.657
MTRNR2L6-0.398
MTRNR2L9-0.381
MTRNR2L10-0.373
P2RY14-0.365
IL18RAP-0.363
KCNJ15-0.363
CXCR2-0.357
FMO3-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1109625,6-dichlorobenzimidazole"5,6-dichlorobenzimidazole promotes the reaction [TNFSF10 protein affects the localization of HTRA2 protein]"15688023
D000082AcetaminophenAcetaminophen results in increased expression of HTRA2 mRNA25704631
C056165acetovanillone[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein]20153346
C430898AGN 194204AGN 194204 results in decreased expression of HTRA2 mRNA16339527
C077990alvocidibalvocidib affects the localization of HTRA2 protein12517783
D000638AmiodaroneAmiodarone results in increased expression of HTRA2 mRNA24489787
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HTRA2 mRNA24449571
C006632arsenic trioxide[arsenic trioxide co-treated with Quercetin] affects the localization of HTRA2 protein18359480
C006632arsenic trioxide[arsenic trioxide co-treated with TNF protein] affects the localization of HTRA2 protein17673311
C006632arsenic trioxidearsenic trioxide results in decreased localization of HTRA2 protein23041229
C006632arsenic trioxidearsenic trioxide results in increased expression of HTRA2 mRNA22521957
C006632arsenic trioxideDeoxyglucose promotes the reaction [arsenic trioxide results in decreased localization of HTRA2 protein]23041229
C006632arsenic trioxide[lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein21889928
D001280AtrazineAtrazine results in increased expression of HTRA2 mRNA22378314
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HTRA2 protein19763263
D004958EstradiolEstradiol affects the expression of HTRA2 mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of HTRA2 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of HTRA2 mRNA21636974
C006780bisphenol Abisphenol A affects the expression of HTRA2 mRNA25181051
D000069286BortezomibBortezomib affects the localization of HTRA2 protein16024631
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HTRA2 mRNA20883709
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HTRA2 mRNA20350560
C012843cinnamic aldehydecinnamic aldehyde affects the localization of HTRA2 protein15566391
C012843cinnamic aldehydeVitamin E inhibits the reaction [cinnamic aldehyde affects the localization of HTRA2 protein]15566391
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HTRA2 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of HTRA2 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of HTRA2 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of HTRA2 mRNA25270620
D003847DeoxyglucoseDeoxyglucose promotes the reaction [arsenic trioxide results in decreased localization of HTRA2 protein]23041229
D003847DeoxyglucoseDeoxyglucose results in decreased localization of HTRA2 protein23041229
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HTRA2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of HTRA2 protein15863139
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of HTRA2 mRNA21636974
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HTRA2 mRNA17602206
D002117CalcitriolCalcitriol results in decreased expression of HTRA2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of HTRA2 mRNA21592394
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of HTRA2 mRNA28939011
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of HTRA2 mRNA24534155
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HTRA2 mRNA22079256
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein]19429258
D000431EthanolEthanol results in increased expression of HTRA2 protein19429258
D005485FlutamideFlutamide results in decreased expression of HTRA2 mRNA24793618
D005839GentamicinsGentamicins results in increased expression of HTRA2 mRNA22061828
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein18951874
D007545IsoproterenolIsoproterenol results in decreased expression of HTRA2 mRNA21335049
C016371lonidamine[lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein21889928
D008727MethotrexateHTRA2 mRNA affects the susceptibility to Methotrexate22753658
D015741MetriboloneMetribolone results in decreased expression of HTRA2 protein17152098
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HTRA2 mRNA"23634900
D026422S-NitrosoglutathioneS-Nitrosoglutathione affects the localization of HTRA2 protein20153346
D026422S-Nitrosoglutathione[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein]20153346
D016627OxidopamineOxidopamine results in increased expression of HTRA2 mRNA19763263
D016627OxidopamineOxidopamine results in increased expression of HTRA2 protein19763263
D019319Okadaic AcidOkadaic Acid affects the expression of HTRA2 mRNA28939011
D010269ParaquatParaquat affects the localization of HTRA2 protein22245251
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HTRA2 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HTRA2 protein26879310
D010695PhlorhizinPhlorhizin results in decreased expression of HTRA2 mRNA22538082
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HTRA2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HTRA2 mRNA22079256
D011791QuartzQuartz results in increased expression of HTRA2 protein27917503
D011794Quercetin[arsenic trioxide co-treated with Quercetin] affects the localization of HTRA2 protein18359480
C059514resveratrolresveratrol results in increased expression of HTRA2 mRNA22610192
D012402RotenoneRotenone results in decreased expression of HTRA2 protein19763263
D012402RotenoneRotenone results in increased expression of HTRA2 protein19763263
D012822Silicon DioxideSilicon Dioxide results in increased expression of HTRA2 protein27917503
D012834SilverSilver results in decreased expression of HTRA2 protein25462594
D019821SimvastatinSimvastatin affects the localization of HTRA2 protein20045437
C017947sodium arsenitesodium arsenite results in decreased expression of HTRA2 mRNA20883709
D012969Sodium FluorideSodium Fluoride results in increased expression of HTRA2 protein28918527
D012999SomanSoman results in decreased expression of HTRA2 mRNA19281266
C001803tempol[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein]20153346
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of HTRA2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HTRA2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HTRA2 mRNA24680724
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein18951874
D014050TolueneToluene affects the expression of HTRA2 mRNA21827849
C012589trichostatin A[vorinostat co-treated with trichostatin A] affects the localization of HTRA2 protein16026644
C501517UCF 101[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein]20153346
C501517UCF 101UCF 101 results in decreased activity of HTRA2 protein15967379|2015334
D014635Valproic AcidValproic Acid affects the expression of HTRA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HTRA2 mRNA23179753|2800136
D014810Vitamin EVitamin E inhibits the reaction [cinnamic aldehyde affects the localization of HTRA2 protein]15566391
C111237vorinostat[vorinostat co-treated with trichostatin A] affects the localization of HTRA2 protein16026644

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IMP10971580  11967569  
GO:0004252serine-type endopeptidase activity-TAS10873535  
GO:0005515protein binding-IPI10971580  11583623  11602612  11604410  11801603  15200957  
17297443  19502560  20125124  24698088  25118933  
GO:0008233peptidase activity-IDA11604410  17266347  20125124  25118933  
GO:0008233peptidase activity-IMP24709290  
GO:0008236serine-type peptidase activity-IDA11583623  
GO:0008236serine-type peptidase activity-TAS18309324  
GO:0042802identical protein binding-IMP11967569  
GO:0051082unfolded protein binding-NAS10644717  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA25118933  
GO:0006508proteolysis-IMP10971580  11967569  24709290  
GO:0006508proteolysis-TAS10873535  
GO:0006672ceramide metabolic process-IEA-  
GO:0007005mitochondrion organization-IEA-  
GO:0007568aging-IEA-  
GO:0007628adult walking behavior-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IMP11602612  
GO:0009635response to herbicide-IEA-  
GO:0010822positive regulation of mitochondrion organization-IMP25118933  
GO:0010942positive regulation of cell death-IDA11583623  
GO:0016540protein autoprocessing-TAS11602612  
GO:0019742pentacyclic triterpenoid metabolic process-IEA-  
GO:0030900forebrain development-IEA-  
GO:0034599cellular response to oxidative stress-IMP24709290  
GO:0034599cellular response to oxidative stress-NAS24522549  
GO:0034605cellular response to heat-IDA10971580  
GO:0035458cellular response to interferon-beta-IDA17297443  
GO:0040014regulation of multicellular organism growth-IEA-  
GO:0043065positive regulation of apoptotic process-IMP11967569  20125124  
GO:0043065positive regulation of apoptotic process-TAS18221368  18309324  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA11583623  11604410  17297443  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP11967569  
GO:0044257cellular protein catabolic process-IDA17297443  
GO:0045786negative regulation of cell cycle-TAS18309324  
GO:0048666neuron development-IEA-  
GO:0070207protein homotrimerization-IMP11967569  
GO:0071300cellular response to retinoic acid-IDA17297443  
GO:0071363cellular response to growth factor stimulus-IMP20125124  
GO:0097194execution phase of apoptosis-TAS18309324  
GO:1901215negative regulation of neuron death-TAS18221368  
GO:1902176negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-NAS18221368  
GO:1903146regulation of autophagy of mitochondrion-TAS24522549  
GO:1903955positive regulation of protein targeting to mitochondrion-HMP24270810  
GO:1904924negative regulation of mitophagy in response to mitochondrial depolarization-IEA-  
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-IMP20125124  
GO:2001269positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-IMP11602612  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IDA24798695  
GO:0005634nucleus-IDA10971580  24798695  
GO:0005739mitochondrion-IDA11583623  11602612  
GO:0005739mitochondrion-IMP11604410  
GO:0005739mitochondrion-TAS18309324  
GO:0005758mitochondrial intermembrane space-IDA15044455  
GO:0005783endoplasmic reticulum-NAS10995577  
GO:0005789endoplasmic reticulum membrane-TAS10644717  
GO:0005829cytosol-IDA11583623  11602612  11604410  24798695  
GO:0005856cytoskeleton-IDA24798695  
GO:0009898cytoplasmic side of plasma membrane-ISS-  
GO:0016020membrane-IDA24798695  
GO:0031966mitochondrial membrane-IEA-  
GO:0035631CD40 receptor complex-ISS-  
GO:1905370serine-type endopeptidase complex-IMP11967569  
KEGG ID KEGG Term
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19429258Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. (2009 Jun 22)Ren JToxicol Lett