Gene: MAT2B

27430
MAT-II|MATIIbeta|Nbla02999|SDR23E1|TGR
methionine adenosyltransferase 2B
protein-coding
5q34
Ensembl:ENSG00000038274 MIM:605527 Vega:OTTHUMG00000130379 UniprotKB:Q9NZL9
NC_000005.10
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.296e-1 (AD)  6.628e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WASL0.963
SHOC20.958
RANBP90.955
NDFIP10.954
ARL8B0.953
PDHX0.95
UBA50.949
UBQLN10.949
REEP50.949
ATF20.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.619
OR4F29-0.579
CSAG1-0.363
MTRNR2L10-0.358
MTRNR2L6-0.345
KLRB1-0.345
VNN3-0.343
MTRNR2L9-0.337
KLF17-0.321
SH2D1A-0.32

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of MAT2B mRNA"18343893
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MAT2B mRNA"23994337
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MAT2B mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MAT2B protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MAT2B protein]26598702
C0293704-toluidine4-toluidine results in increased expression of MAT2B mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of MAT2B mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAT2B gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of MAT2B mRNA"23195993
D000638AmiodaroneAmiodarone affects the expression of MAT2B mRNA25064622
D001151ArsenicArsenic affects the expression of MAT2B mRNA18487201
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MAT2B protein]26598702
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of MAT2B mRNA23994337
C044887beta-methylcholinebeta-methylcholine affects the expression of MAT2B mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of MAT2B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAT2B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of MAT2B mRNA26079696
D002746ChlorpromazineChlorpromazine affects the expression of MAT2B mRNA25064622
D009249NADPNADP binds to and results in increased activity of MAT2B protein25526675
D009249NADP[resveratrol co-treated with NADP] binds to MAT2B protein25526675
D019327Copper SulfateCopper Sulfate results in decreased expression of MAT2B mRNA19549813
D016572CyclosporineCyclosporine affects the expression of MAT2B mRNA25064622
D002945CisplatinCisplatin results in increased expression of MAT2B mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of MAT2B mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MAT2B mRNA25064622
C039281furanfuran results in decreased methylation of MAT2B gene22079235
C492448ICG 001ICG 001 results in increased expression of MAT2B mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAT2B mRNA25613284
D007854LeadLead affects the expression of MAT2B mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAT2B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAT2B mRNA"25554681
D009532NickelNickel results in decreased expression of MAT2B mRNA23195993
D010269ParaquatParaquat affects the expression of MAT2B mRNA25064622
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MAT2B protein26178269
C006253pirinixic acidpirinixic acid results in increased expression of MAT2B mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in increased expression of MAT2B mRNA23608068
C015586propiverinepropiverine binds to MAT2B protein29273565
C059514resveratrolELAVL1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B protein]23814050
C059514resveratrolMAT2B mutant form inhibits the reaction [resveratrol results in increased expression of ELAVL1 protein]23814050
C059514resveratrolMAT2B mutant form inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]23814050
C059514resveratrolMAT2B mutant form inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]23814050
C059514resveratrol[resveratrol co-treated with NADP] binds to MAT2B protein25526675
C059514resveratrolresveratrol inhibits the reaction [MAT2B protein binds to MAT2A protein]23814050
C059514resveratrolresveratrol promotes the reaction [ELAVL1 protein binds to MAT2B mRNA]23814050
C059514resveratrolresveratrol promotes the reaction [MAT2B protein binds to ELAVL1 protein]23814050
C059514resveratrolresveratrol promotes the reaction [MAT2B protein binds to SIRT1 protein]23814050
C059514resveratrolresveratrol results in increased expression of and results in increased stability of MAT2B mRNA23814050
C059514resveratrolresveratrol results in increased expression of and results in increased stability of MAT2B protein23814050
C059514resveratrolresveratrol results in increased expression of MAT2B mRNA23814050
C059514resveratrolSIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B mRNA]23814050
C059514resveratrolSIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B protein]23814050
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAT2B mRNA18343893|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAT2B mRNA15328365|2399433
D013752TetracyclineTetracycline affects the expression of MAT2B mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAT2B mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of MAT2B protein"25852303
D013853ThioacetamideThioacetamide affects the expression of MAT2B mRNA25064622
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MAT2B gene27618143
D014501UraniumUranium affects the expression of MAT2B mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of MAT2B mRNA15672453
D014635Valproic AcidValproic Acid affects the expression of MAT2B mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of MAT2B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MAT2B mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of MAT2B mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25075345  25416956  
GO:0019899enzyme binding-IPI10644686  
GO:0048270methionine adenosyltransferase regulator activity-IDA10644686  25075345  
GO ID GO Term Qualifier Evidence PubMed
GO:0006556S-adenosylmethionine biosynthetic process-IDA10644686  25075345  
GO:0006556S-adenosylmethionine biosynthetic process-IEA-  
GO:0006730one-carbon metabolic process-IEA-  
GO:0050790regulation of catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IC10644686  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA-  
GO:0005829cytosol-TAS-  
GO:0048269methionine adenosyltransferase complex-IDA10644686  25075345  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22724053One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore. (2012)Inoue-Choi MInt J Mol Epidemiol Genet
28369960Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain. (2017 Jun)Auta JAlcohol Clin Exp Res
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr