Gene: POLM

27434
Pol Mu|Tdt-N
DNA polymerase mu
protein-coding
7p13
Ensembl:ENSG00000122678 MIM:606344 Vega:OTTHUMG00000155353 UniprotKB:Q9NP87
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
4.020e-1 (AD)  NA (ND)   (Frontal_Cortex)
6.470e-1 (AD)  8.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF10.85
PHYKPL0.815
ADAM150.807
DNM20.802
SLC26A60.794
SLC8B10.792
DNHD10.79
TTC7A0.786
MYO15B0.78
ARHGAP170.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.483
OR4F29-0.463
OR2T10-0.2
KCNG1-0.196
EPPIN-0.194
HOXC5-0.192
NEK2-0.186
BEND4-0.174
AKAP14-0.172
GSG1-0.167

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of POLM mRNA17562736
D000666Amphotericin BAmphotericin B results in increased expression of POLM mRNA20849824
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of POLM mRNA26377693
D004958EstradiolEstradiol affects the expression of POLM mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of POLM mRNA21179406
C006780bisphenol Abisphenol A affects the expression of POLM mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of POLM gene28505145
D000069286BortezomibBortezomib results in decreased expression of POLM mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of POLM mRNA21297351
D002994ClofibrateClofibrate results in decreased expression of POLM mRNA17585979|2381119
D003471CuprizoneCuprizone results in decreased expression of POLM mRNA26577399
D003520CyclophosphamideCyclophosphamide results in increased expression of POLM mRNA20849824
D002945CisplatinCisplatin results in increased expression of POLM mRNA20849824
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of POLM mRNA"19480007
C069837fullerene C60fullerene C60 results in increased expression of POLM mRNA19167457
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of POLM gene28505145
D005839GentamicinsGentamicins results in increased expression of POLM mRNA20849824
C060893MK-886MK-886 results in decreased activity of POLM protein23305233
C028007nickel monoxidenickel monoxide results in increased expression of POLM mRNA19167457
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of POLM mRNA19710929
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of POLM mRNA16497877
D013654TaurineTaurine results in increased expression of POLM mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POLM mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of POLM mRNA25975270

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003887DNA-directed DNA polymerase activity-TAS-  
GO:0005515protein binding-IPI22458338  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006310DNA recombination-IEA-  
GO:0016446somatic hypermutation of immunoglobulin genes-IBA21873635  
GO:0016446somatic hypermutation of immunoglobulin genes-IEA-  
GO:0030183B cell differentiation-IEA-  
GO:0071897DNA biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa03450Non-homologous end-joining
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21668961Predictors of web-based follow-up response in the Prevention Of Low Back Pain In The Military Trial (POLM). (2011 Jun 13)Childs JDBMC Musculoskelet Disord