Gene: GLRX

2745
GRX|GRX1
glutaredoxin
protein-coding
5q15
Ensembl:ENSG00000173221 MIM:600443 Vega:OTTHUMG00000121167 UniprotKB:P35754
NG_029797.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.634e-1 (AD)  2.531e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOD20.827
WARS0.809
TPST10.808
SLC39A140.803
GTF2E20.798
IFNGR20.798
ELL20.79
UAP10.787
WTAP0.784
YIPF10.783

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.42
P2RY14-0.395
GPR17-0.385
OR4F5-0.374
TNS3-0.363
NXNL1-0.351
EYA1-0.346
MUSTN1-0.345
C16orf96-0.345
OR4F29-0.344

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0208881,2-dielaidoylphosphatidylethanolamine"1,2-dielaidoylphosphatidylethanolamine results in decreased expression of GLRX mRNA"14668052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLRX mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of GLRX mRNA"20406850
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of GLRX mRNA"20638727
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of GLRX mRNA"21218783
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX mRNA"27188386
C0671348-oxo-7-hydrodeoxyguanosineGLRX gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine19896490
D000082AcetaminophenAcetaminophen results in decreased expression of GLRX mRNA11793227|2142099
D000111AcetylcysteineGLRX protein affects the susceptibility to Acetylcysteine17468103
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[cupric chloride co-treated with Buthionine Sulfoximine] results in decreased activity of GLRX protein]20566629
D020106AcrylamideAcrylamide results in decreased expression of GLRX mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLRX mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLRX gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLRX mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of GLRX mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GLRX mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GLRX mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GLRX mRNA24449571
D016718Arachidonic AcidGLRX protein affects the susceptibility to Arachidonic Acid19373248
D001194AsbestosAsbestos affects the expression of GLRX mRNA17297452
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GLRX mRNA]23470461
D001379AzathioprineAzathioprine results in increased expression of GLRX mRNA22623647
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with Penicillamine] inhibits the reaction [GLRX protein binds to ATP7A protein]20566629
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of GLRX mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLRX mRNA22209252
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLRX mRNA21632981|2623829
D004958EstradiolEstradiol results in decreased expression of GLRX mRNA23019147
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GLRX mRNA26496021
C006780bisphenol Abisphenol A affects the expression of GLRX mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GLRX mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of GLRX mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GLRX mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GLRX mRNA22079614
D002065BuspironeBuspirone results in increased expression of GLRX mRNA24136188
D019328Buthionine SulfoximineAcetylcysteine inhibits the reaction [[cupric chloride co-treated with Buthionine Sulfoximine] results in decreased activity of GLRX protein]20566629
D019328Buthionine Sulfoximine[cupric chloride co-treated with Buthionine Sulfoximine] results in decreased activity of GLRX protein20566629
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GLRX mRNA12414654
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GLRX mRNA18804290
D020122tert-Butylhydroperoxide[GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]12680778
D002101Cacodylic AcidCacodylic Acid results in increased expression of GLRX mRNA17720352
D002104CadmiumCadmium results in increased expression of GLRX mRNA17327700
D002104CadmiumCadmium results in decreased activity of GLRX protein16785314
D002104CadmiumGLRX protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]16785314
D002104CadmiumIDH2 protein inhibits the reaction [Cadmium results in decreased activity of GLRX protein]16785314
D002104Cadmiumoxalomalic acid promotes the reaction [Cadmium results in decreased activity of GLRX protein]16785314
D019256Cadmium Chloride[Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]20351055
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GLRX mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GLRX protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GLRX mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of GLRX protein16785314
D019256Cadmium ChlorideGLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]16785314
D019256Cadmium ChlorideIDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]16785314
D019256Cadmium Chlorideoxalomalic acid promotes the reaction [Cadmium Chloride results in decreased activity of GLRX protein]16785314
D002110CaffeineCaffeine results in decreased expression of GLRX mRNA11793227
D002330CarmustineCarmustine results in decreased activity of GLRX protein17431186
C100187chloropicrinchloropicrin affects the expression of GLRX mRNA26352163
C012843cinnamic aldehyde[Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]20351055
C012843cinnamic aldehydecinnamic aldehyde results in increased activity of GLRX protein20351055
C012843cinnamic aldehyde[cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]20351055
C012843cinnamic aldehyde[cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]20351055
C012843cinnamic aldehyde[cinnamic aldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein20351055
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of GLRX mRNA20351055
C018021cobaltous chloridecobaltous chloride results in decreased expression of GLRX mRNA24386269
D003300CopperCopper binds to GLRX protein24522867
D003300CopperGLRX protein results in decreased uptake of and results in decreased abundance of and results in decreased susceptibility to Copper24816595
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of GLRX mRNA20971185
D003300CopperGLRX protein results in decreased uptake of and results in decreased abundance of and results in decreased susceptibility to Copper24816595
D003300CopperCopper results in increased expression of GLRX mRNA22465980
D003300CopperGLRX protein affects the transport of Copper20566629
D019327Copper SulfateCopper Sulfate results in increased expression of GLRX mRNA19549813
C029892cupric chlorideAcetylcysteine inhibits the reaction [[cupric chloride co-treated with Buthionine Sulfoximine] results in decreased activity of GLRX protein]20566629
C029892cupric chloride[cupric chloride co-treated with Buthionine Sulfoximine] results in decreased activity of GLRX protein20566629
C029892cupric chloridecupric chloride promotes the reaction [GLRX protein binds to ATP7A protein]20566629
C029892cupric chloridecupric chloride results in decreased activity of GLRX protein20566629
D016572CyclosporineCyclosporine results in increased expression of GLRX mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of GLRX mRNA19770486
C093628cyproconazolecyproconazole results in increased expression of GLRX mRNA22334560
D013759DronabinolDronabinol results in decreased expression of GLRX mRNA16616335
D003907DexamethasoneDexamethasone results in increased expression of GLRX mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GLRX mRNA21266533
D002945CisplatinCisplatin results in increased expression of GLRX mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of GLRX mRNA26924002
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GLRX mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GLRX mRNA15171707|2104116
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of GLRX mRNA25270620
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of GLRX mRNA17547211
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of GLRX mRNA26924002
D004178DiquatGLRX gene mutant form results in increased susceptibility to Diquat17893043
D004237DiuronDiuron results in increased expression of GLRX mRNA21551480
D007980LevodopaLevodopa results in decreased activity of GLRX protein21815648
D004317DoxorubicinGLRX protein results in decreased susceptibility to Doxorubicin16160061
C118739entinostatentinostat results in increased expression of GLRX mRNA27188386
C109476epoxiconazoleepoxiconazole results in increased expression of GLRX mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GLRX mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLRX mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GLRX mRNA17557909
C007738fluoranthenefluoranthene results in decreased expression of GLRX mRNA28329830
C056507gemcitabinegemcitabine results in increased expression of GLRX mRNA17039268
D005944GlucosamineGlucosamine results in increased expression of GLRX mRNA17178593
D005947GlucoseGLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]24451382
D005947GlucoseGLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein]24451382
D005978Glutathione[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
D005978Glutathione[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
D005978GlutathioneGLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]24451382
D005978Glutathione[GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]12680778
D005978GlutathioneGlutathione affects the activity of GLRX protein20566629
D019803Glutathione DisulfideGLRX protein affects the susceptibility to Glutathione Disulfide19373248
D017313FenretinideFenretinide results in increased expression of GLRX mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GLRX mRNA12414654
C492448ICG 001ICG 001 results in decreased expression of GLRX mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of GLRX mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GLRX mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GLRX mRNA25613284
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of GLRX mRNA25119042
C410337K 7174K 7174 results in increased expression of GLRX mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of GLRX mRNA24967691
C045463leflunomideleflunomide results in increased expression of GLRX mRNA24136188
D008070LipopolysaccharidesGLRX protein promotes the reaction [Lipopolysaccharides results in increased expression of CSF2 protein]20539014
D008070LipopolysaccharidesGLRX protein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]20539014
D008070LipopolysaccharidesGLRX protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]20539014
D008070LipopolysaccharidesGLRX protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]20539014
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of GLRX protein20539014
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GLRX mRNA25613284
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GLRX mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GLRX mRNA26378955
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of GLRX mRNA20843944
D008627Mercuric ChlorideMercuric Chloride affects the metabolism of GLRX protein18321861
D008751Methylene Blue[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA24556215
C004925methylmercuric chloridemethylmercuric chloride affects the expression of GLRX protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of and results in decreased activity of GLRX protein27180086
C540575MK2i peptide[TGFB1 protein co-treated with MK2i peptide] results in decreased expression of GLRX protein20864298
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of GLRX mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of GLRX mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GLRX mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GLRX mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of GLRX mRNA24136188
D009532NickelNickel results in decreased expression of GLRX mRNA23195993
C022838nickel chloridenickel chloride results in increased expression of GLRX mRNA17547211
C022838nickel chloridenickel chloride affects the expression of GLRX mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of GLRX mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GLRX mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of GLRX mRNA20971185
C015407oxalomalic acidoxalomalic acid promotes the reaction [Cadmium Chloride results in decreased activity of GLRX protein]16785314
C015407oxalomalic acidoxalomalic acid promotes the reaction [Cadmium results in decreased activity of GLRX protein]16785314
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of GLRX mRNA25658374
D010126OzoneOzone results in increased expression of GLRX mRNA16716893
D019308Palmitic AcidGLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]24451382
D019308Palmitic AcidGLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein]24451382
D010269ParaquatGLRX gene mutant form results in increased susceptibility to Paraquat17893043
D010269ParaquatParaquat results in increased expression of GLRX mRNA12732627
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of GLRX mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of GLRX mRNA25119042
D010396Penicillamine[bathocuproine sulfonate co-treated with Penicillamine] inhibits the reaction [GLRX protein binds to ATP7A protein]20566629
D010416PentachlorophenolPentachlorophenol results in increased expression of GLRX mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GLRX protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GLRX mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GLRX mRNA26794494
D010634PhenobarbitalPhenobarbital affects the expression of GLRX mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GLRX mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GLRX mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GLRX mRNA15728792
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of GLRX mRNA17498859
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GLRX mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of GLRX mRNA18301758|1844570
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GLRX mRNA22714537
D011192Potassium DichromateAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GLRX mRNA]23470461
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GLRX mRNA23470461
C045950propiconazolepropiconazole results in increased expression of GLRX mRNA22334560
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of GLRX mRNA14699072
C089730rosiglitazonerosiglitazone results in increased expression of GLRX mRNA21515302
D012643SeleniumSelenium deficiency results in increased expression of GLRX mRNA16170372
D012643SeleniumSelenium results in increased expression of GLRX mRNA16170372
D012643SeleniumSelenium affects the expression of GLRX mRNA19351701
C009277sodium arsenate[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
C009277sodium arsenate[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
C017947sodium arsenitesodium arsenite results in increased expression of GLRX mRNA12016162|1237797
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GLRX mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GLRX mRNA26378955
C016766sulforafansulforafan results in increased expression of GLRX mRNA26833863
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of GLRX mRNA"26680231
C061133tamibarotenetamibarotene results in increased expression of GLRX mRNA15498508
C501413tesaglitazartesaglitazar results in increased expression of GLRX mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of GLRX mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLRX mRNA12377990|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GLRX mRNA19684285|2623829
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLRX mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLRX mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLRX mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GLRX mRNA17035482
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLRX mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GLRX mRNA18796159|2121527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GLRX mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of GLRX protein20109541
D013853ThioacetamideThioacetamide results in decreased expression of GLRX mRNA11793227
C009495titanium dioxidetitanium dioxide results in increased expression of GLRX mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GLRX mRNA28065790
D014212TretinoinTretinoin results in increased expression of GLRX mRNA15498508|2372400
D014212TretinoinTretinoin results in decreased expression of GLRX mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of GLRX mRNA24935251|2718838
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GLRX mRNA19042947
C057693troglitazonetroglitazone results in increased expression of GLRX mRNA21515302
C406224valdecoxibvaldecoxib results in decreased expression of GLRX mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLRX mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GLRX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GLRX gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GLRX mRNA23179753|2627250
D014638VanadatesVanadates results in increased expression of GLRX mRNA22714537
D024483Vitamin K 3Vitamin K 3 results in increased expression of GLRX mRNA12414654
C111237vorinostatvorinostat results in increased expression of GLRX mRNA22083351|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0009055electron transfer activity-IEA-  
GO:0015038glutathione disulfide oxidoreductase activity-EXP7851394  
GO:0047485protein N-terminus binding-IPI16884690  
GO:0097573glutathione oxidoreductase activity-TAS19542013  
GO ID GO Term Qualifier Evidence PubMed
GO:0015949nucleobase-containing small molecule interconversion-TAS-  
GO:0022900electron transport chain-IEA-  
GO:0045454cell redox homeostasis-IEA-  
GO:0045838positive regulation of membrane potential-IDA19542013  
GO:0080058protein deglutathionylation-TAS19542013  
GO:2000651positive regulation of sodium ion transmembrane transporter activity-IDA19542013  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS16884690  
GO:0070062extracellular exosome-HDA18570454  19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23688726Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)Tang WFree Radic Biol Med