Gene: GLUD1

2746
GDH|GDH1|GLUD
glutamate dehydrogenase 1
protein-coding
10q23.2
Ensembl:ENSG00000148672 MIM:138130 Vega:OTTHUMG00000018666 UniprotKB:P00367
NG_013010.1
PubMed
0   ANCO-SNPs
ND|AD
2   
8.113e-1 (AD)  6.386e-2 (ND)   (Frontal_Cortex)
7.204e-1 (AD)  6.938e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH20.942
SRI0.941
ALDH9A10.938
HADHB0.925
TMBIM60.921
NADK20.917
PRDX60.914
HADHA0.914
PON20.908
DDAH10.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.717
OR4F29-0.705
FAM160A1-0.243
RHO-0.24
OPRD1-0.238
CACNA1F-0.238
PROKR2-0.233
QRFPR-0.229
COL19A1-0.222
NPBWR2-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245671,1,2-trichloroethane"1,1,2-trichloroethane results in increased expression of GLUD1 protein"1489524
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLUD1 mRNA"19114083
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of GLUD1 protein"27604104
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of GLUD1 protein"19033394
C0047262-dichlorobenzenecyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C0047262-dichlorobenzenemethylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C0047262-dichlorobenzenemethyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C0047262-dichlorobenzene2-dichlorobenzene results in increased activity of GLUD1 protein3012827
C0047262-dichlorobenzenecyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C0047262-dichlorobenzenemethylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C0047262-dichlorobenzenemethyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of GLUD1 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GLUD1 mRNA"19692669
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in decreased expression of GLUD1 protein"22649188
C0615595'-4-(fluorosulfonyl)benzoyl-8-azidoadenosine5'-4-(fluorosulfonyl)benzoyl-8-azidoadenosine binds to and affects the activity of GLUD1 protein2817902
D000082AcetaminophenAcetaminophen results in decreased expression of GLUD1 mRNA11793227|2906747
D000082AcetaminophenAcetaminophen results in increased expression of GLUD1 protein16538043|1668747
D020106AcrylamideAcrylamide results in decreased expression of GLUD1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GLUD1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLUD1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLUD1 gene27153756
C029743alpha-ketoglutaric aciddipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]26639393
C029743alpha-ketoglutaric acid[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]26639393
C010845aluminum chloridealuminum chloride binds to and affects the folding of and results in decreased activity of GLUD1 protein14625697
C010845aluminum chlorideCitric Acid inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]14625697
C010845aluminum chlorideSodium Fluoride inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]14625697
D000625Aminooxyacetic Aciddipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]26639393
D000625Aminooxyacetic Acid[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]26639393
D000638AmiodaroneAmiodarone results in increased expression of GLUD1 protein16538043
D000641Ammoniadipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]26639393
D000641Ammonia[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]26639393
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GLUD1 mRNA16483693
C023650anilineaniline results in increased nitrosation of GLUD1 protein21708182
C006632arsenic trioxidearsenic trioxide results in decreased expression of GLUD1 protein19364129
C006632arsenic trioxidearsenic trioxide results in increased expression of GLUD1 protein25419056
D001280AtrazineAtrazine results in increased expression of GLUD1 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of GLUD1 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GLUD1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLUD1 protein17292933
D004958EstradiolEstradiol promotes the reaction [GLUD1 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in increased expression of GLUD1 mRNA25181051
C423844BL 11282BL 11282 results in increased expression of GLUD1 protein17458497
C032036bromobenzenebromobenzene results in increased activity of GLUD1 protein3012827
C584509C646 compoundC646 compound results in increased expression of GLUD1 mRNA26191083
D002110CaffeineCaffeine results in decreased expression of GLUD1 mRNA11793227
C459604candoxincandoxin results in decreased expression of GLUD1 mRNA16309724
D002211CapsaicinCapsaicin results in increased expression of GLUD1 protein18991268
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of GLUD1 protein26639393
D002251Carbon Tetrachloridedipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]26639393
D002251Carbon Tetrachloride[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]26639393
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GLUD1 protein16538043
C054133casticincasticin results in decreased expression of GLUD1 mRNA28444820
D002108CeruletideCeruletide results in increased expression of GLUD1 protein18024178
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of GLUD1 protein21791222
D019343Citric AcidCitric Acid inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]14625697
D002994ClofibrateClofibrate results in decreased expression of GLUD1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of GLUD1 mRNA22300585
D009249NADPdipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]26639393
D009249NADP[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]26639393
D003300CopperCopper analog results in increased expression of GLUD1 protein23882024
D003300CopperCopper results in decreased expression of GLUD1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of GLUD1 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of GLUD1 mRNA17211630
C029892cupric chloridecupric chloride results in increased expression of GLUD1 mRNA24650576
C030973cupric oxidecupric oxide analog results in increased expression of GLUD1 protein23882024
C036468cyclohexanonecyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C036468cyclohexanonecyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
D016572CyclosporineCyclosporine results in decreased expression of GLUD1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of GLUD1 mRNA23830897
C093628cyproconazolecyproconazole results in decreased expression of GLUD1 mRNA22334560
D013759DronabinolDronabinol results in decreased expression of GLUD1 mRNA17578508
D004006DichlorvosDichlorvos results in decreased activity of GLUD1 protein4004835
D002117CalcitriolCalcitriol results in increased expression of GLUD1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GLUD1 mRNA21592394
C004860dipicolinic aciddipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with alpha-ketoglutaric acid co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]]26639393
C004860dipicolinic aciddipicolinic acid results in decreased activity of GLUD1 protein26639393
D004237DiuronDiuron results in increased expression of GLUD1 mRNA21551480
C109476epoxiconazoleepoxiconazole results in decreased expression of GLUD1 mRNA22334560
D000431EthanolEthanol results in increased expression of GLUD1 protein23200777
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GLUD1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GLUD1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GLUD1 mRNA17942748
D005839GentamicinsGentamicins results in decreased expression of GLUD1 protein22061828
D005839GentamicinsGentamicins results in increased expression of GLUD1 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of GLUD1 mRNA24136188
D005947GlucoseGlucose affects the expression of GLUD1 mRNA24349266
C410337K 7174K 7174 results in decreased expression of GLUD1 mRNA24086573
D007854LeadLead affects the expression of GLUD1 mRNA28903495
D008345ManganeseManganese deficiency results in decreased expression of GLUD1 protein21312047
D008345ManganeseParoxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]21312047
C005222methylethyl ketonemethylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C005222methylethyl ketonemethylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C005458methyl isobutyl ketonemethyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C005458methyl isobutyl ketonemethyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]2554539
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GLUD1 protein25809596
C004925methylmercuric chloridemethylmercuric chloride affects the expression of GLUD1 protein27178136
C051752nefazodonenefazodone results in decreased expression of GLUD1 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of GLUD1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GLUD1 protein19716841
C025256nonylphenolnonylphenol results in decreased expression of GLUD1 mRNA22982499
D010100OxygenOxygen deficiency results in decreased expression of GLUD1 protein25937538
D017374ParoxetineParoxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]21312047
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of GLUD1 protein19954255
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GLUD1 mRNA18281256
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of GLUD1 mRNA17097637
D010936Plant ExtractsPlant Extracts results in increased expression of GLUD1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of GLUD1 protein18563748
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GLUD1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of GLUD1 mRNA23018184
C045950propiconazolepropiconazole results in decreased expression of GLUD1 mRNA22334560
C015586propiverinepropiverine binds to GLUD1 protein29273565
D011794QuercetinQuercetin results in decreased expression of GLUD1 mRNA21632981
D012524SarinSarin results in decreased expression of GLUD1 mRNA19522546
D012643SeleniumSelenium affects the expression of GLUD1 protein19351701
D012835Silver NitrateSilver Nitrate results in increased expression of GLUD1 mRNA22727896
C080703SK&F 83959SK&F 83959 affects the expression of GLUD1 protein25852303
D012969Sodium FluorideSodium Fluoride inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]14625697
D012969Sodium FluorideSodium Fluoride results in decreased expression of GLUD1 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of GLUD1 mRNA18175754
D020058StyreneStyrene affects the expression of GLUD1 mRNA28678435
D013629TamoxifenTamoxifen results in decreased expression of GLUD1 protein17098229
D013629Tamoxifen[Tretinoin co-treated with Tamoxifen] results in decreased expression of GLUD1 protein17098229
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of GLUD1 mRNA15885361
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GLUD1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of GLUD1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLUD1 mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GLUD1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLUD1 mRNA16960034|1879615
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLUD1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLUD1 mRNA16054898|1696003
D013752TetracyclineTetracycline results in increased expression of GLUD1 protein16538043
D013853ThioacetamideThioacetamide results in decreased expression of GLUD1 mRNA11793227
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GLUD1 protein27319396
D014212Tretinoin[Tretinoin co-treated with Tamoxifen] results in decreased expression of GLUD1 protein17098229
D014212TretinoinTretinoin results in decreased expression of GLUD1 protein17098229
C012589trichostatin Atrichostatin A results in decreased expression of GLUD1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GLUD1 mRNA"26179874
C406224valdecoxibvaldecoxib results in decreased expression of GLUD1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of GLUD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GLUD1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of GLUD1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004352glutamate dehydrogenase (NAD+) activity-IDA11903050  15578726  
GO:0004353glutamate dehydrogenase [NAD(P)+] activity-EXP11903050  
GO:0004353glutamate dehydrogenase [NAD(P)+] activity-IDA11032875  
GO:0005515protein binding-IPI16959573  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IDA11032875  
GO:0042802identical protein binding-TAS11903050  
GO:0043531ADP binding-IDA12742085  
GO:0070403NAD+ binding-IDA12193607  
GO:0070728leucine binding-IDA12742085  
GO ID GO Term Qualifier Evidence PubMed
GO:0006537glutamate biosynthetic process-IDA11032875  
GO:0006538glutamate catabolic process-IDA6121377  11032875  
GO:0006541glutamine metabolic process-ISS-  
GO:0008652cellular amino acid biosynthetic process-TAS-  
GO:0021762substantia nigra development-HEP22926577  
GO:0032024positive regulation of insulin secretion-IMP11502802  
GO:0055114oxidation-reduction process-IEA-  
GO:0072350tricarboxylic acid metabolic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA18688271  
GO:0005739mitochondrion-IDA15578726  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa00471D-Glutamine and D-glutamate metabolism
hsa00910Nitrogen metabolism
hsa01100Metabolic pathways
hsa04964Proximal tubule bicarbonate reclamation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25538565GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics. (2014)Bhandage AKFront Cell Neurosci
25803269Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)Filis PJ Clin Endocrinol Metab