Gene info: ID 2747

Gene: GLUD2

GENE ID: 2747

Synonyms: GDH2|GLUDP1

Description: glutamate dehydrogenase 2

Gene type: protein-coding

Location: Xq24

dbXrefs: Ensembl:ENSG00000182890 MIM:300144 Vega:OTTHUMG00000022320 UniprotKB:P49448

RefSeq: NG_016456.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABHD2	0.608
ZSCAN12	0.601
ZNF778	0.594
SNRK	0.593
NFAT5	0.59
ZNF426	0.588
ZNF791	0.585
CCNT1	0.585
POLR1B	0.584
EML4	0.58

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM31	-0.341
LHPP	-0.328
MCM7	-0.328
C19orf81	-0.323
HMX1	-0.319
FOXO4	-0.318
S1PR5	-0.31
NEU4	-0.309
C7orf61	-0.307
NKX6-2	-0.303

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of GLUD2 mRNA"	20206263
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of GLUD2 mRNA	25704631\|2906747
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GLUD2 mRNA	22316170\|2623829
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of GLUD2 mRNA	22154832
D004958	Estradiol	Estradiol results in increased expression of GLUD2 mRNA	22154832
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of GLUD2 mRNA]	22154832
C006780	bisphenol A	bisphenol A promotes the reaction [GLUD2 protein binds to ESR1 protein]	27156127
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GLUD2 mRNA	18409656
D002220	Carbamazepine	Carbamazepine affects the expression of GLUD2 mRNA	25979313
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of GLUD2 mRNA	26272509
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of GLUD2 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of GLUD2 mRNA	20106945\|2556210
D002117	Calcitriol	Calcitriol results in increased expression of GLUD2 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of GLUD2 mRNA	21592394
C118739	entinostat	entinostat results in decreased expression of GLUD2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
D004397	Fonofos	Fonofos results in increased methylation of GLUD2 promoter	22847954
C410337	K 7174	K 7174 results in decreased expression of GLUD2 mRNA	24086573
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GLUD2 mRNA	28001369
D010278	Parathion	Parathion results in increased methylation of GLUD2 promoter	22847954
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of GLUD2 mRNA	26272509
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of GLUD2 mRNA	22154832
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of GLUD2 mRNA]	22154832
D011794	Quercetin	Quercetin results in decreased expression of GLUD2 protein	15221776
C061133	tamibarotene	tamibarotene affects the expression of GLUD2 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of GLUD2 mRNA	14699072
C012568	terbufos	terbufos results in increased methylation of GLUD2 promoter	22847954
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of GLUD2 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of GLUD2 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GLUD2 mRNA	21296121
D014212	Tretinoin	Tretinoin results in decreased expression of GLUD2 mRNA	15498508
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of GLUD2 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of GLUD2 mRNA	23179753\|2438349
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLUD2 mRNA"	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004352	glutamate dehydrogenase (NAD+) activity	-	IDA	8207021 15578726
GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	-	IDA	11032875
GO:0005525	GTP binding	-	IDA	11032875
GO:0043531	ADP binding	-	IDA	12742085
GO:0070728	leucine binding	-	IDA	12742085

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006536	glutamate metabolic process	-	IDA	8207021
GO:0006537	glutamate biosynthetic process	-	IDA	11032875
GO:0006538	glutamate catabolic process	-	IDA	11032875
GO:0055114	oxidation-reduction process	-	IDA	8207021

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	NOT	IDA	18688271
GO:0005739	mitochondrion	-	IDA	18688271

KEGG ID	KEGG Term
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00330	Arginine and proline metabolism
hsa00471	D-Glutamine and D-glutamate metabolism
hsa00910	Nitrogen metabolism
hsa01100	Metabolic pathways
hsa04964	Proximal tubule bicarbonate reclamation

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25278838	Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics. (2014)	Jin Z	Front Cell Neurosci
25538565	GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics. (2014)	Bhandage AK	Front Cell Neurosci