Gene: AMT

275
GCE|GCST|GCVT|NKH
aminomethyltransferase
protein-coding
3p21.31
Ensembl:ENSG00000145020 MIM:238310 Vega:OTTHUMG00000156847 UniprotKB:P48728
NG_015986.1
PubMed
0   ANCO-SNPs
ND|AD
2   
9.550e-2 (AD)  6.086e-1 (ND)   (Frontal_Cortex)
5.613e-1 (AD)  3.705e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACBD40.838
MST10.835
SCRN20.83
IL11RA0.826
SPPL2B0.821
NPEPL10.818
HSF40.812
TTC21A0.807
QTRT10.803
TTLL30.801

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.57
OR4F29-0.529
CNTF-0.232
PAGE4-0.226
HAS2-0.226
ARHGEF38-0.218
TMEM236-0.216
TMSB15A-0.215
PPBP-0.214
SPRR4-0.209

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of AMT mRNA25704631
D020106AcrylamideAcrylamide results in increased expression of AMT mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AMT mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of AMT mRNA28522335
D001280AtrazineAtrazine results in increased expression of AMT mRNA25929836
C006780bisphenol Abisphenol A affects the expression of AMT mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of AMT mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of AMT mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of AMT mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of AMT mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of AMT mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AMT mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA28628672
C016366dibenzothiophenedibenzothiophene results in decreased expression of AMT mRNA23656968
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AMT mRNA27392435
D002945CisplatinCisplatin results in increased expression of AMT mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of AMT mRNA25016146
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of AMT mRNA22169935
D004147DioxinsDioxins affects the expression of AMT mRNA20463971
D004237DiuronDiuron results in increased expression of AMT mRNA21551480
D018120FinasterideFinasteride results in increased expression of AMT mRNA24136188
D005472FluorouracilFluorouracil results in increased expression of AMT protein15585135|1680352
D005485FlutamideFlutamide results in increased expression of AMT mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AMT mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AMT mRNA27392435
C544151jinfukangjinfukang results in increased expression of AMT mRNA27392435
C045463leflunomideleflunomide results in decreased expression of AMT mRNA28988120
C045463leflunomideleflunomide results in increased expression of AMT mRNA24136188
C008493methylselenic acidmethylselenic acid results in increased expression of AMT mRNA18548127
D008777MethyltestosteroneMethyltestosterone results in decreased expression of AMT mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AMT mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AMT mRNA"25620056
C051752nefazodonenefazodone results in increased expression of AMT mRNA24136188
D009532NickelNickel results in decreased expression of AMT mRNA24768652|2558310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AMT protein26879310
D010938Plant OilsPlant Oils results in decreased expression of AMT mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of AMT mRNA21334430
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AMT mRNA28903501
D011794QuercetinQuercetin results in decreased expression of AMT mRNA21632981
C009277sodium arsenatesodium arsenate results in increased expression of AMT mRNA23922661
D013467SulindacSulindac results in increased expression of AMT mRNA24136188
D019284ThapsigarginThapsigargin results in increased expression of AMT mRNA22378314
C012589trichostatin Atrichostatin A results in increased expression of AMT mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of AMT mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of AMT mRNA22378314
D014520UrethaneUrethane results in decreased expression of AMT mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AMT mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AMT mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of AMT mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004047aminomethyltransferase activity-IBA21873635  
GO:0004047aminomethyltransferase activity-IMP16051266  
GO:0004047aminomethyltransferase activity-TAS-  
GO:0008483transaminase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006546glycine catabolic process-TAS9600239  
GO:0019464glycine decarboxylation via glycine cleavage system-IBA21873635  
GO:0019464glycine decarboxylation via glycine cleavage system-IMP16051266  
GO:0032259methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IC16051266  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa00670One carbon pool by folate
hsa00910Nitrogen metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-6783984Glycine degradationTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8078981New state markers for alcoholism. Comparison of carbohydrate deficient transferrin (CDT) and alcohol mediated (triantennary) transferrin (AMT). (1994 May)Kanitz RDProg Neuropsychopharmacol Biol Psychiatry
23098584Diabetic foot reconstruction using free flaps increases 5-year-survival rate. (2013 Feb)Oh TSJ Plast Reconstr Aesthet Surg