Gene info: ID 2752

Gene: GLUL

GENE ID: 2752

Synonyms: GLNS|GS|PIG43|PIG59

Description: glutamate-ammonia ligase

Gene type: protein-coding

Location: 1q25.3

dbXrefs: Ensembl:ENSG00000135821 MIM:138290 Vega:OTTHUMG00000037407 UniprotKB:P15104

RefSeq: NG_013347.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.963e-1 (AD) 6.892e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg26430597	chr1:182354699	GLUL	Gene body	2.719e-5	Alcohol use disorders	26763658
cg15067127	chr1:182352978	GLUL	3'UTR	2.216e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EZR	0.902
CDC42EP4	0.9
SLC9A3R1	0.899
PTN	0.894
GLUD1	0.891
ATP1B2	0.885
ALDH2	0.884
APOE	0.88
PON2	0.879
SLC25A18	0.876

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.617
OR4F29	-0.607
TYRP1	-0.344
LIPH	-0.333
IL12RB2	-0.331
ZNF860	-0.327
PAQR9	-0.316
THEM5	-0.316
ADTRP	-0.311
SLIT3	-0.311

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00130	L-Glutamine	Small Molecule	56-85-9	Approved\|Investigational\|Nutraceutical	Target
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00082	Pegvisomant	BiotechDrug	218620-50-9	Approved	Enzyme
DB00134	Methionine	Small Molecule	63-68-3	Approved\|Nutraceutical	Enzyme
DB00466	Picrotoxin	Small Molecule	124-87-8	Experimental	Enzyme
DB01119	Diazoxide	Small Molecule	364-98-7	Approved	Enzyme
DB01212	Ceftriaxone	Small Molecule	73384-59-5	Approved	Enzyme
DB06774	Capsaicin	Small Molecule	404-86-4	Approved	Enzyme
DB08794	Ethyl biscoumacetate	Small Molecule	548-00-5	Withdrawn	Enzyme

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of GLUL mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GLUL mRNA"	22698814
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GLUL protein"	21705713
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"CTNNB1 gene mutant form affects the susceptibility to [1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of GLUL protein]"	21705713
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"GLUL protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CTNNB1 protein modified form]"	21705713
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GLUL mRNA	19933214
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of GLUL protein"	21673325
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLUL mRNA"	19114083
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of GLUL mRNA"	27604104
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of GLUL mRNA"	20959002
C057349	2,4-decadienal	"2,4-decadienal results in increased expression of GLUL mRNA"	22363721
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of GLUL mRNA"	20406850
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GLUL mRNA"	15215175
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene affects the expression of GLUL mRNA"	21346803
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone affects the expression of GLUL mRNA"	20206263
C012587	3,5,6-trichloro-2-pyridinol	"3,5,6-trichloro-2-pyridinol results in decreased activity of GLUL protein"	15541749
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of GLUL mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLUL mRNA"	27188386
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to GLUL protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GLUL protein]	26598702
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of GLUL mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLUL mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of GLUL mRNA	22230336\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of GLUL mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of GLUL mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GLUL mRNA]	17585979
D000086	Acetazolamide	Acetazolamide results in increased expression of GLUL mRNA	19274763
D020106	Acrylamide	Acrylamide results in decreased expression of GLUL mRNA	12853321
D020106	Acrylamide	Acrylamide results in increased expression of GLUL mRNA	28959563
C000188	alachlor	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
C103303	alitretinoin	alitretinoin results in increased expression of GLUL mRNA	15982314
D000493	Allopurinol	Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]	24491314
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin affects the expression of GLUL protein	26072098
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog affects the expression of GLUL protein	26072098
C104223	aluminum lactate	aluminum lactate results in increased activity of GLUL protein	8104402
C104223	aluminum lactate	aluminum lactate results in increased expression of GLUL mRNA	8104402
D000641	Ammonia	GLUL affects the susceptibility to Ammonia	19073408
D000641	Ammonia	GLUL protein affects the metabolism of Ammonia	19073408
D000641	Ammonia	GLUL protein affects the metabolism of Ammonia	19088795\|2006493
D000641	Ammonia	Ammonia results in decreased activity of GLUL protein	26318273
D000641	Ammonia	Ammonia results in increased activity of GLUL protein	26318273
D000641	Ammonia	[Methionine Sulfoximine results in decreased activity of GLUL protein] which results in increased abundance of Ammonia	19619585
D000641	Ammonia	resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]	26318273
D000641	Ammonia	zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]	26318273
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GLUL protein	16483693
D000643	Ammonium Chloride	Ammonium Chloride affects the metabolism of GLUL protein	11923223
D000643	Ammonium Chloride	Ammonium Chloride results in decreased activity of GLUL protein	11923223
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GLUL mRNA	24449571
C058317	arsenic disulfide	arsenic disulfide results in increased activity of GLUL protein	24865513
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GLUL protein]	26598702
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GLUL mRNA	15894607
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of GLUL mRNA	15894607
D001280	Atrazine	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D001414	Bacitracin	Bacitracin results in increased expression of GLUL mRNA	18289764
D001554	Benzene	Benzene results in increased expression of GLUL mRNA	19162166
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GLUL mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GLUL mRNA	26238291
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of GLUL mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GLUL mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GLUL mRNA	21569818\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GLUL mRNA"	19150397
D004958	Estradiol	Estradiol results in increased expression of GLUL mRNA	19167446
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of GLUL mRNA	22154832
D004958	Estradiol	Estradiol results in increased expression of GLUL mRNA	22154832
C006780	bisphenol A	bisphenol A results in decreased methylation of GLUL promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of GLUL mRNA	15901920
C006780	bisphenol A	bisphenol A results in increased expression of GLUL mRNA	24988533
D002104	Cadmium	Cadmium results in increased expression of GLUL mRNA	24376830
D002104	Cadmium	Cadmium results in increased expression of GLUL mRNA	17327700
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GLUL mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GLUL mRNA	17327700
D019256	Cadmium Chloride	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GLUL protein	23680456
D002220	Carbamazepine	Carbamazepine results in decreased activity of GLUL protein	10323596
D012721	Carbaryl	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of GLUL protein	26639393
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GLUL mRNA	25566828\|2663939
D005023	Ethylene Chlorohydrin	Ethylene Chlorohydrin results in decreased expression of and results in decreased activity of GLUL protein	27596522
D005023	Ethylene Chlorohydrin	Ethylene Chlorohydrin results in decreased expression of GLUL mRNA	27596522
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of GLUL mRNA	25270620
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of GLUL mRNA	23650126
D002737	Chloroprene	Chloroprene results in increased expression of GLUL mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GLUL gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of GLUL mRNA	28472532
C418118	CI 1044	CI 1044 results in increased expression of GLUL mRNA	17569694
D002922	Ciguatoxins	Ciguatoxins affects the expression of GLUL mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of GLUL mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GLUL mRNA]	17585979
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of GLUL mRNA	20971185
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in increased expression of GLUL protein	20931265
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of GLUL mRNA	15467011
D003345	Corticosterone	Corticosterone results in increased expression of GLUL mRNA	15755911
D003471	Cuprizone	Cuprizone results in decreased expression of GLUL mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of GLUL mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of GLUL mRNA	19770486\|2383089
C017160	cypermethrin	cypermethrin results in decreased activity of GLUL protein	24649940
D003907	Dexamethasone	Dexamethasone results in increased expression of GLUL mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GLUL mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of GLUL mRNA	22733784\|2293672
D003907	Dexamethasone	trichostatin A inhibits the reaction [Dexamethasone results in increased expression of GLUL mRNA]	23946490
D003907	Dexamethasone	Valproic Acid inhibits the reaction [Dexamethasone results in increased expression of GLUL mRNA]	23946490
D004041	Dietary Fats	Dietary Fats results in decreased expression of GLUL mRNA	18042831
C014476	diethyl maleate	diethyl maleate results in decreased expression of GLUL mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GLUL protein	18978308
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GLUL mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GLUL mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GLUL mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GLUL protein	20932895
D002117	Calcitriol	Calcitriol results in decreased expression of GLUL mRNA	16002434
D011397	Promegestone	methoxyacetic acid promotes the reaction [Promegestone results in increased expression of GLUL mRNA]	15103026
D011397	Promegestone	Promegestone results in increased expression of GLUL mRNA	15103026
D004237	Diuron	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D004237	Diuron	Diuron results in decreased expression of GLUL mRNA	21551480\|2515243
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GLUL mRNA"	23811387
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GLUL mRNA"	23262642
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GLUL protein"	23262642
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GLUL protein	23301498
D000431	Ethanol	Ethanol results in increased expression of GLUL mRNA	15353170
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GLUL mRNA	17555576\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLUL mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GLUL mRNA	12655037
C047360	felbamate	felbamate results in decreased activity of GLUL protein	10323596
D005411	Flame Retardants	Flame Retardants results in decreased expression of GLUL protein	18550172
D005485	Flutamide	Flutamide results in decreased expression of GLUL mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GLUL gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of GLUL mRNA	27664576
C053504	fosetyl-Al	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D005632	Fructose	Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein]	24491314
D005632	Fructose	Fructose results in decreased expression of GLUL protein	24491314
D005632	Fructose	Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein]	24491314
C056933	fumonisin B1	fumonisin B1 results in decreased expression of GLUL mRNA	16221962
D019833	Genistein	Genistein results in decreased expression of GLUL mRNA	16705744
D005947	Glucose	Glucose results in decreased expression of and results in decreased activity of GLUL protein	26677078
D005947	Glucose	Glucose results in decreased expression of GLUL mRNA	26677078
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of GLUL protein]	26677078
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in decreased expression of GLUL mRNA]	26677078
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of GLUL mRNA	22634610
C010974	glyphosate	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D006220	Haloperidol	Haloperidol results in decreased expression of GLUL mRNA	15860345
C001335	hexachlorobutadiene	hexachlorobutadiene results in increased expression of GLUL protein	10463391
D017313	Fenretinide	Fenretinide results in increased expression of GLUL mRNA	28973697
D006851	Hydrochloric Acid	Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein]	20719974
D002112	Calcifediol	Calcifediol deficiency results in decreased expression of GLUL mRNA	17293106
D007213	Indomethacin	Indomethacin results in decreased expression of GLUL mRNA	17401462
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GLUL mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GLUL mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GLUL mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in increased expression of GLUL mRNA	20003209
D007649	Ketamine	Ketamine results in increased expression of GLUL protein	18504422
D007854	Lead	Lead results in increased expression of GLUL protein	15955607
C008261	lead acetate	lead acetate results in decreased expression of GLUL mRNA	25270620
C008261	lead acetate	lead acetate results in increased expression of GLUL mRNA	20542052
C008261	lead acetate	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GLUL protein	23680456
C045463	leflunomide	leflunomide results in increased expression of GLUL mRNA	28988120
D001556	Lindane	Lindane results in decreased expression of GLUL mRNA	17785943
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of GLUL gene	21212295
D008345	Manganese	Manganese results in decreased expression of GLUL	19337503
D008345	Manganese	Manganese affects the expression of GLUL mRNA	16842851
D008345	Manganese	Manganese affects the expression of GLUL protein	16842851
D008345	Manganese	Manganese results in decreased expression of GLUL mRNA	16943606
D008345	Manganese	Manganese results in decreased expression of GLUL protein	16943606
D008345	Manganese	Manganese results in increased activity of GLUL protein	21254280
D008345	Manganese	Nickel inhibits the reaction [Manganese results in increased activity of GLUL protein]	21254280
C025340	manganese chloride	manganese chloride results in decreased expression of GLUL mRNA	19615351
C025340	manganese chloride	manganese chloride results in decreased expression of GLUL protein	19615351
C025340	manganese chloride	Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]	19615351
C025340	manganese chloride	Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA]	19615351
C039798	manganese sulfate	manganese sulfate results in decreased expression of GLUL protein	19520674
C039798	manganese sulfate	manganese sulfate results in decreased expression of GLUL mRNA	15894815
C039798	manganese sulfate	manganese sulfate results in decreased expression of GLUL protein	15894815
C039798	manganese sulfate	manganese sulfate results in increased expression of GLUL mRNA	15894815
C039798	manganese sulfate	manganese sulfate results in decreased expression of GLUL mRNA	16943606
C039798	manganese sulfate	manganese sulfate results in decreased expression of GLUL protein	16943606
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GLUL gene	20938992
D008717	Methionine Sulfoximine	Methionine Sulfoximine results in decreased activity of GLUL protein	19619585
D008717	Methionine Sulfoximine	[Methionine Sulfoximine results in decreased activity of GLUL protein] which results in increased abundance of Ammonia	19619585
C013598	methoxyacetic acid	methoxyacetic acid promotes the reaction [Promegestone results in increased expression of GLUL mRNA]	15103026
C004925	methylmercuric chloride	methylmercuric chloride results in decreased activity of GLUL protein	22223486
C004925	methylmercuric chloride	Polyphenols inhibits the reaction [methylmercuric chloride results in decreased activity of GLUL protein]	22223486
C051786	metolachlor	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D015741	Metribolone	Metribolone results in increased expression of GLUL protein	17152098
D008942	Mitoxantrone	GLUL protein affects the susceptibility to Mitoxantrone	16217747
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of GLUL protein	24625837
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GLUL mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GLUL mRNA"	25554681\|2562005
D009285	Naphthoquinones	Naphthoquinones results in increased expression of GLUL mRNA	23811387
C502362	N-butyrylglucosamine	N-butyrylglucosamine results in increased expression of GLUL mRNA	16142878
C051752	nefazodone	nefazodone results in decreased expression of GLUL mRNA	24136188
D019829	Nevirapine	Nevirapine metabolite results in decreased expression of GLUL mRNA	23947594
D009532	Nickel	Nickel results in increased expression of GLUL mRNA	24768652\|2558310
D009532	Nickel	Nickel binds to GLUL protein	21254280
D009532	Nickel	Nickel inhibits the reaction [Manganese results in increased activity of GLUL protein]	21254280
C029938	nickel sulfate	nickel sulfate results in increased expression of GLUL mRNA	22714537
C012655	nimesulide	nimesulide results in decreased expression of GLUL mRNA	24136188
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of GLUL mRNA	19716841
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of GLUL mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in decreased activity of GLUL protein	20558201
C025589	ochratoxin A	ochratoxin A results in decreased expression of GLUL mRNA	12700408
D010100	Oxygen	[SCH 442416 co-treated with Oxygen deficiency] results in increased expression of GLUL mRNA	22969972
D010126	Ozone	Ozone results in increased expression of GLUL mRNA	25838073
D000073878	Palm Oil	Palm Oil results in decreased expression of GLUL mRNA	18042831
D010269	Paraquat	[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GLUL protein	24376630
D010269	Paraquat	Paraquat results in increased expression of GLUL protein	24521700
D010269	Paraquat	SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GLUL protein]	24376630
D052638	Particulate Matter	Particulate Matter analog results in decreased expression of GLUL mRNA	15541757
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of GLUL protein	18550172
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of GLUL protein	25616259
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GLUL mRNA	19162173
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of GLUL protein	27825932
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GLUL mRNA	27825932
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GLUL mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of GLUL mRNA	18281256
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GLUL mRNA	19162173
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GLUL mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of GLUL mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased activity of GLUL protein	10323596
D010634	Phenobarbital	Phenobarbital results in decreased expression of GLUL mRNA	25270620
D010634	Phenobarbital	Phenobarbital results in increased expression of GLUL mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of GLUL protein	12384525
D010634	Phenobarbital	[Phenobarbital results in increased mutagenesis of CTNNB1 gene] which results in increased expression of GLUL mRNA	12384525
D010634	Phenobarbital	[Phenobarbital results in increased mutagenesis of CTNNB1 gene] which results in increased expression of GLUL protein	12384525
D010634	Phenobarbital	Phenobarbital results in decreased expression of GLUL mRNA	19162173
D010672	Phenytoin	Phenytoin results in decreased activity of GLUL protein	10323596
C003121	phosphinothricin	phosphinothricin results in increased expression of and results in increased activity of GLUL protein	27031874
C003121	phosphinothricin	phosphinothricin results in increased expression of GLUL mRNA	27031874
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of GLUL mRNA	22484513
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GLUL mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of GLUL mRNA	17426115\|2381119
D010936	Plant Extracts	Plant Extracts results in increased expression of GLUL mRNA	23262642
D010936	Plant Extracts	Plant Extracts results in increased expression of GLUL protein	23262642
D010938	Plant Oils	Plant Oils results in increased expression of GLUL mRNA	23370395
D059808	Polyphenols	Polyphenols inhibits the reaction [methylmercuric chloride results in decreased activity of GLUL protein]	22223486
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GLUL protein	23718831
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of GLUL protein	10463391
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of GLUL mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of GLUL mRNA	22154832
D011374	Progesterone	Progesterone results in increased expression of GLUL mRNA	20726854
C045950	propiconazole	propiconazole results in decreased expression of GLUL mRNA	19363144
C015586	propiverine	propiverine binds to GLUL protein	29273565
D011794	Quercetin	Quercetin inhibits the reaction [Fructose results in decreased expression of GLUL protein]	24491314
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of GLUL mRNA	16079270
D017382	Reactive Oxygen Species	[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GLUL protein	24376630
D017382	Reactive Oxygen Species	SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GLUL protein]	24376630
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of GLUL mRNA	25905778
C059514	resveratrol	resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]	26318273
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of GLUL protein]	26677078
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in decreased expression of GLUL mRNA]	26677078
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL mRNA]	26677078
C059514	resveratrol	resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL protein]	26677078
C059514	resveratrol	resveratrol results in increased activity of GLUL protein	17554623
C059514	resveratrol	resveratrol results in increased expression of GLUL protein	16904623
C059514	resveratrol	zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]	26318273
C059514	resveratrol	zinc protoporphyrin inhibits the reaction [resveratrol results in increased activity of GLUL protein]	26318273
D015474	Isotretinoin	Isotretinoin results in increased expression of GLUL mRNA	15982314
D019782	Riluzole	Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]	19615351
D019782	Riluzole	Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA]	19615351
C541923	sandostatinLAR	sandostatinLAR results in decreased expression of GLUL mRNA	17210224
D012524	Sarin	Sarin results in decreased expression of GLUL mRNA	19522546
D012524	Sarin	Sarin results in increased expression of GLUL mRNA	19522546
C093642	SB 203580	SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in decreased expression of GLUL protein]	24376630
C416650	SCH 442416	[SCH 442416 co-treated with Oxygen deficiency] results in increased expression of GLUL mRNA	22969972
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GLUL mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of GLUL mRNA	25351596
C080703	SK&F 83959	SK&F 83959 affects the expression of GLUL protein	25852303
C009277	sodium arsenate	sodium arsenate results in decreased expression of GLUL mRNA	12727804
C009277	sodium arsenate	sodium arsenate affects the methylation of GLUL promoter	20667999
C009277	sodium arsenate	sodium arsenate results in increased expression of GLUL mRNA	20667999
C017947	sodium arsenite	sodium arsenite results in decreased expression of GLUL mRNA	25270620
C017947	sodium arsenite	sodium arsenite results in increased expression of GLUL mRNA	21396911
C017947	sodium arsenite	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GLUL protein	23680456
C017947	sodium arsenite	sodium arsenite results in decreased expression of and results in decreased activity of GLUL protein	22020379
C016104	sodium bichromate	sodium bichromate results in decreased expression of GLUL mRNA	17685462
D012999	Soman	Soman results in increased expression of GLUL mRNA	19281266
D053260	Soot	Soot results in increased expression of GLUL mRNA	26551751
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of GLUL mRNA	25905778
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL mRNA]	26677078
D013311	Streptozocin	resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL protein]	26677078
D013311	Streptozocin	Streptozocin results in decreased expression of GLUL mRNA	26677078
D013311	Streptozocin	Streptozocin results in decreased expression of GLUL protein	26677078
D013629	Tamoxifen	Tamoxifen affects the expression of GLUL mRNA	17555576
D013629	Tamoxifen	Tamoxifen results in decreased expression of GLUL mRNA	25123088
C037565	terbutylazine	[alachlor co-treated with metolachlor co-treated with Atrazine co-treated with terbutylazine co-treated with Diuron co-treated with fosetyl-Al co-treated with Carbaryl co-treated with glyphosate] results in increased activity of GLUL protein	22012874
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GLUL mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLUL mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of GLUL gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GLUL mRNA	16960034\|2527062
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GLUL mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased methylation of GLUL gene	21212295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GLUL mRNA	16054898\|1696003
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GLUL mRNA	25613284
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of GLUL protein"	25852303
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of GLUL mRNA	28943392
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in increased expression of GLUL protein	20931265
D013974	Thyroxine	Thyroxine results in increased expression of GLUL mRNA	17403546
C009495	titanium dioxide	titanium dioxide results in decreased activity of GLUL protein	25411160
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GLUL mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in decreased expression of GLUL mRNA	26489853
D014050	Toluene	Toluene results in decreased expression of GLUL mRNA	22166486
D014050	Toluene	Toluene results in increased expression of GLUL mRNA	22166486
C052342	topiramate	topiramate results in decreased activity of GLUL protein	10323596
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of GLUL mRNA	15894607
D014212	Tretinoin	Tretinoin metabolite results in increased expression of GLUL mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of GLUL mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of GLUL mRNA	15894607\|1598231
D014212	Tretinoin	Tretinoin results in increased expression of GLUL mRNA	28689802
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of GLUL mRNA	19448997
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GLUL mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of GLUL mRNA	26272509
C012589	trichostatin A	trichostatin A inhibits the reaction [Dexamethasone results in increased expression of GLUL mRNA]	23946490
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GLUL mRNA"	24407104
C057693	troglitazone	troglitazone results in increased expression of GLUL protein	21315101
D014501	Uranium	Uranium affects the expression of GLUL mRNA	15672453
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of GLUL mRNA	19654044
C005460	uranyl acetate	uranyl acetate affects the expression of GLUL mRNA	15672453
D014508	Urea	GLUL protein affects the chemical synthesis of Urea	20064933
D014520	Urethane	Urethane results in increased expression of GLUL mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of GLUL mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of GLUL mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of GLUL mRNA	28001369
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Dexamethasone results in increased expression of GLUL mRNA]	23946490
D014638	Vanadates	Vanadates results in decreased expression of GLUL mRNA	22714537
D014640	Vancomycin	Vancomycin results in increased expression of GLUL mRNA	18930951
D014640	Vancomycin	Vancomycin results in increased expression of GLUL mRNA	18289764
D001335	Vehicle Emissions	Vehicle Emissions analog results in decreased expression of GLUL mRNA	15541757
C025643	vinclozolin	vinclozolin affects the expression of GLUL mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of GLUL mRNA	26682919
D014800	Vitallium	Vitallium analog results in increased expression of GLUL mRNA	23825117
D015032	Zinc	Zinc results in increased expression of GLUL mRNA	17074742
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]	26318273
C017803	zinc protoporphyrin	zinc protoporphyrin inhibits the reaction [resveratrol results in increased activity of GLUL protein]	26318273
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of GLUL mRNA	17074742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0004351	glutamate decarboxylase activity	-	IEA	-
GO:0004356	glutamate-ammonia ligase activity	-	EXP	18005987
GO:0005515	protein binding	-	IPI	21994455 25910212
GO:0005524	ATP binding	-	IEA	-
GO:0016595	glutamate binding	-	IEA	-
GO:0030145	manganese ion binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	16189514 19447967 21988832 25416956
GO:0045503	dynein light chain binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001504	neurotransmitter uptake	-	TAS	-
GO:0006538	glutamate catabolic process	-	TAS	21757002
GO:0006542	glutamine biosynthetic process	-	TAS	21757002
GO:0008283	cell proliferation	-	IDA	18662667
GO:0008652	cellular amino acid biosynthetic process	-	TAS	-
GO:0009267	cellular response to starvation	-	IEA	-
GO:0009749	response to glucose	-	IEA	-
GO:0019676	ammonia assimilation cycle	-	IEA	-
GO:0032024	positive regulation of insulin secretion	-	IEA	-
GO:0050679	positive regulation of epithelial cell proliferation	-	IEA	-
GO:0051260	protein homooligomerization	-	IEA	-
GO:0051968	positive regulation of synaptic transmission, glutamatergic	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005739	mitochondrion	-	IDA	-
GO:0005791	rough endoplasmic reticulum	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0032991	protein-containing complex	-	IEA	-
GO:0043204	perikaryon	-	IEA	-
GO:0043209	myelin sheath	-	IEA	-
GO:0043679	axon terminus	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867
GO:0097386	glial cell projection	-	IEA	-

KEGG ID	KEGG Term
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00330	Arginine and proline metabolism
hsa00910	Nitrogen metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-112313	Neurotransmitter uptake and metabolism In glial cells	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	TAS
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28167353	Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)	Shahid SU	Atherosclerosis