Gene: GMDS

2762
GMD|SDR3E1
GDP-mannose 4,6-dehydratase
protein-coding
6p25.3
Ensembl:ENSG00000112699 MIM:602884 Vega:OTTHUMG00000016143 UniprotKB:O60547
NC_000006.12
SNP Mapped
5   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.279e-2 (AD)  4.179e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4463305chr6:1918338 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2281760chr6:1866292 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3800091chr6:1837594 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3823270chr6:1781739 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs3800043chr6:1764090 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18132076chr6:1970710GMDS1.400e-16Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TESC0.82
SMIM120.818
NANS0.808
MRPL90.805
UXS10.804
PSMD80.801
TUSC10.796
FLAD10.795
MAD2L1BP0.794
LYPLA20.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.491
OR4F29-0.449
PARD3B-0.357
ASB4-0.351
GLI3-0.347
GLI1-0.344
FREM2-0.34
ENDOU-0.34
CDC14A-0.334
ACSS3-0.33

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02547Guanosine-5'-Diphosphate-RhamnoseSmall MoleculeExperimentalTarget
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GMDS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GMDS mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GMDS mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of GMDS mRNA22230336|2669055
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GMDS protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GMDS mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GMDS mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of GMDS mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GMDS mRNA24449571
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GMDS mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GMDS mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GMDS mRNA19770486|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GMDS mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of GMDS mRNA21179406
C006780bisphenol Abisphenol A affects the expression of GMDS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GMDS mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of GMDS mRNA26063408
C006780bisphenol Abisphenol A affects the expression of GMDS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GMDS mRNA25181051
C584509C646 compoundC646 compound results in increased expression of GMDS mRNA26191083
C459604candoxincandoxin results in decreased expression of GMDS mRNA16309724
D002746ChlorpromazineChlorpromazine affects the expression of GMDS mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of GMDS mRNA19376846
D009249NADPNADP binds to and results in increased activity of GMDS protein25526675
D019327Copper SulfateCopper Sulfate results in decreased expression of GMDS mRNA19549813
D016572CyclosporineCyclosporine affects the expression of GMDS mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of GMDS mRNA27989131
C014347decitabinedecitabine results in decreased expression of GMDS mRNA19194470
D003907DexamethasoneDexamethasone results in increased expression of GMDS mRNA22733784
D003976DiazinonDiazinon results in increased methylation of GMDS gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GMDS mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GMDS mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GMDS mRNA19561079|2739243
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GMDS mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GMDS mRNA25242112
D004147DioxinsDioxins affects the expression of GMDS mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GMDS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GMDS mRNA25064622
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of GMDS mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of GMDS mRNA23649840
C039281furanfuran results in increased expression of GMDS mRNA27387713
D006153Guanosine DiphosphateGuanosine Diphosphate binds to GMDS protein25526675
D006157Guanosine MonophosphateGuanosine Monophosphate binds to GMDS protein25526675
D006165Guanylyl ImidodiphosphateGuanylyl Imidodiphosphate binds to GMDS protein25526675
C492448ICG 001ICG 001 results in increased expression of GMDS mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GMDS mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GMDS mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GMDS mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GMDS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GMDS mRNA"25554681
D010269ParaquatParaquat affects the expression of GMDS mRNA25064622
D010634PhenobarbitalPhenobarbital affects the expression of GMDS mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of GMDS mRNA18301758
C045950propiconazolepropiconazole results in increased expression of GMDS mRNA21278054
D011794QuercetinQuercetin results in decreased expression of GMDS mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GMDS mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of GMDS protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GMDS mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GMDS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GMDS mRNA22298810
D013752TetracyclineTetracycline affects the expression of GMDS mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GMDS mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of GMDS mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of GMDS mRNA25064622
D019772TopotecanGMDS protein affects the susceptibility to Topotecan16217747
D014635Valproic AcidValproic Acid affects the expression of GMDS mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GMDS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GMDS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GMDS mRNA23179753|2519280
D014640VancomycinVancomycin results in decreased expression of GMDS mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  27107014  
GO:0008446GDP-mannose 4,6-dehydratase activity-IBA21873635  
GO:0008446GDP-mannose 4,6-dehydratase activity-IDA9525924  
GO:0008446GDP-mannose 4,6-dehydratase activity-IGI9603974  
GO:0008446GDP-mannose 4,6-dehydratase activity-TAS-  
GO:0042802identical protein binding-IPI16189514  25416956  
GO:0070401NADP+ binding-IDA9525924  
GO ID GO Term Qualifier Evidence PubMed
GO:0007219Notch signaling pathway-ISS-  
GO:0019673GDP-mannose metabolic process-IBA21873635  
GO:0019673GDP-mannose metabolic process-IDA9525924  
GO:0019673GDP-mannose metabolic process-IGI9603974  
GO:0042351'de novo' GDP-L-fucose biosynthetic process-IBA21873635  
GO:0042351'de novo' GDP-L-fucose biosynthetic process-IDA9525924  
GO:0042351'de novo' GDP-L-fucose biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IC9525924  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6787639GDP-fucose biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal