Gene: GNA12

2768
NNX3|RMP|gep
G protein subunit alpha 12
protein-coding
7p22.3-p22.2
Ensembl:ENSG00000146535 MIM:604394 Vega:OTTHUMG00000023064 UniprotKB:Q03113
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.732e-1 (AD)  2.339e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26517831chr7:2768566GNA123'UTR6.420e-4Alcohol use disorders26763658
cg18446336chr7:2847575GNA121.100e-12Smoking27651444
cg19717773chr7:2847554GNA126.500e-12Smoking27651444
cg09658497chr7:2847517GNA128.300e-12Smoking27651444
cg11884933chr7:2774414GNA123.300e-11Smoking27651444
cg25318189chr7:2800436GNA125.600e-11Smoking27651444
cg09658497chr7:2847517GNA121.870e-11Smoking28686328
cg19717773chr7:2847554GNA129.670e-10Smoking28686328
cg18446336chr7:2847575GNA121.840e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBL1X0.907
ITPKB0.899
SZRD10.896
LRP100.89
RAB310.883
MRVI10.879
ABHD40.879
CNN30.878
FAM107A0.877
PALLD0.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.556
PPEF1-0.542
TYRP1-0.533
ZNF860-0.533
CALHM1-0.528
NRG1-0.526
ADTRP-0.518
AGMAT-0.518
GRM8-0.516
NELL1-0.513

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased expression of GNA12 mRNA"25270620
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of GNA12 mRNA"19162173
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of GNA12 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GNA12 mRNA"27291303
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of GNA12 mRNA"20826375
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GNA12 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in increased expression of GNA12 mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GNA12 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNA12 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GNA12 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNA12 mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [GNA12 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in increased expression of GNA12 mRNA20826375
C044887beta-methylcholinebeta-methylcholine affects the expression of GNA12 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of GNA12 mRNA21786754
C006780bisphenol Abisphenol A promotes the reaction [GNA12 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in increased expression of GNA12 mRNA20826375
C006780bisphenol Abisphenol A results in increased methylation of GNA12 promoter27312807
C006780bisphenol Abisphenol A affects the expression of GNA12 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of GNA12 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GNA12 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNA12 mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of GNA12 mRNA25979313
D004390ChlorpyrifosChlorpyrifos affects the expression of GNA12 mRNA17452286
D002994ClofibrateClofibrate results in decreased expression of GNA12 mRNA17585979
D003024ClozapineClozapine results in decreased expression of GNA12 mRNA15860345
C018021cobaltous chloridecobaltous chloride results in decreased expression of GNA12 mRNA19320972
D003471CuprizoneCuprizone results in decreased expression of GNA12 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GNA12 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNA12 mRNA28628672
D003976DiazinonDiazinon affects the expression of GNA12 mRNA17452286
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of GNA12 mRNA28962523
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GNA12 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of GNA12 mRNA19467301
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GNA12 mRNA21658437
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of GNA12 mRNA12655031
D000431EthanolEthanol results in increased expression of GNA12 mRNA20655511
D018120FinasterideFinasteride results in increased expression of GNA12 mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of GNA12 mRNA18035473
D005473FluoxetineFluoxetine results in increased expression of GNA12 mRNA1426031
C069837fullerene C60fullerene C60 results in increased expression of GNA12 mRNA19167457
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of GNA12 mRNA21782745
D006220HaloperidolHaloperidol results in decreased expression of GNA12 mRNA15860345
D002112CalcifediolCalcifediol deficiency results in decreased expression of GNA12 mRNA17293106
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNA12 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GNA12 mRNA28628672
D007657Ketone BodiesKetone Bodies results in decreased expression of GNA12 mRNA16807920
D001556LindaneLindane affects the expression of GNA12 mRNA17785943
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of GNA12 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of GNA12 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased methylation of GNA12 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GNA12 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GNA12 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of GNA12 mRNA"29244179
C028007nickel monoxidenickel monoxide results in increased expression of GNA12 mRNA19167457
D010126OzoneOzone results in decreased expression of GNA12 mRNA16330353
D052638Particulate MatterParticulate Matter results in increased expression of GNA12 mRNA24769257
D010634PhenobarbitalPhenobarbital results in decreased expression of GNA12 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GNA12 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of GNA12 mRNA18301758
D011374ProgesteroneProgesterone results in decreased expression of GNA12 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of GNA12 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GNA12 mRNA23221170
C009277sodium arsenatesodium arsenate results in increased expression of GNA12 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of GNA12 mRNA20308225
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of GNA12 mRNA16214533
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNA12 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GNA12 mRNA15800033
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of GNA12 gene26756918
C057693troglitazonetroglitazone results in decreased expression of GNA12 mRNA28973697
D014520UrethaneUrethane results in increased expression of GNA12 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GNA12 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GNA12 mRNA23179753|2519280
C025643vinclozolinvinclozolin results in decreased expression of GNA12 mRNA23034163
D014873Water PollutantsWater Pollutants results in decreased expression of GNA12 mRNA23591932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-TAS-  
GO:0005515protein binding-IPI10026210  
GO:0005525GTP binding-IEA-  
GO:0031683G-protein beta/gamma-subunit complex binding-IBA21873635  
GO:0031752D5 dopamine receptor binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0007596blood coagulation-TAS8290554  
GO:0008360regulation of cell shape-IEA-  
GO:0010762regulation of fibroblast migration-ISS-  
GO:0030154cell differentiation-IEA-  
GO:0030168platelet activation-TAS-  
GO:0032006regulation of TOR signaling-IMP22609986  
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process-IMP22609986  
GO:0042493response to drug-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005834heterotrimeric G-protein complex-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0016328lateral plasma membrane-IEA-  
GO:0031526brush border membrane-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-109582HemostasisIEA
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)IEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147396Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009 Aug)Cheong SCOral Oncol