Gene: GNA15

2769
GNA16
G protein subunit alpha 15
protein-coding
19p13.3
Ensembl:ENSG00000060558 MIM:139314 Vega:OTTHUMG00000180637 UniprotKB:P30679
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
1.227e-1 (AD)  7.582e-1 (ND)   (Frontal_Cortex)
3.640e-1 (AD)  5.299e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASSF50.69
LRMP0.673
GLIPR10.672
SERPINF10.665
ARRB20.662
SEPT60.657
TM6SF10.655
DPY19L10.655
CORO1A0.655
LDHA0.651

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYOM1-0.456
ZFHX4-0.443
EYA1-0.397
ASB4-0.396
PARD3B-0.381
NPFFR1-0.366
ZFHX4-AS1-0.363
PPARA-0.349
RFTN2-0.347
GPAM-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GNA15 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GNA15 mRNA"19114083
C0573492,4-decadienal"GNA15 protein results in increased susceptibility to 2,4-decadienal"15598656
C0573492,4-decadienal"[GNA15 protein results in increased susceptibility to 2,4-decadienal] which results in increased activity of OLFR43 protein"15598656
C4128862,4-nonadienal"GNA15 protein results in increased susceptibility to 2,4-nonadienal"15598656
C4128862,4-nonadienal"[GNA15 protein results in increased susceptibility to 2,4-nonadienal] which results in increased activity of OLFR43 protein"15598656
C0971962,6-nonadienal"GNA15 protein results in increased susceptibility to 2,6-nonadienal"15598656
C0971962,6-nonadienal"[GNA15 protein results in increased susceptibility to 2,6-nonadienal] which results in increased activity of OLFR43 protein"15598656
C0119172-heptanoneGNA15 protein results in increased susceptibility to 2-heptanone15598656
C0119172-heptanone[GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OLFR154 protein15598656
D000082AcetaminophenAcetaminophen results in decreased expression of GNA15 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of GNA15 mRNA28959563
C011879alpha-iononeGNA15 protein results in increased susceptibility to alpha-ionone15598656
C011879alpha-ionone[GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OLFR43 protein15598656
C512486alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde"GNA15 protein results in increased susceptibility to alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde"15598656
C512486alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde"[GNA15 protein results in increased susceptibility to alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde] which results in increased activity of OLFR43 protein"15598656
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNA15 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GNA15 mRNA24449571
C010038azelaic acidGNA15 protein results in increased susceptibility to azelaic acid15598656
C010038azelaic acid[GNA15 protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein15598656
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GNA15 mRNA27195522
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of GNA15 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of GNA15 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GNA15 mRNA25181051
C473193bourgeonalGNA15 protein results in increased susceptibility to bourgeonal15598656
C473193bourgeonal[GNA15 protein results in increased susceptibility to bourgeonal] which results in increased activity of OLFR43 protein15598656
C018475butyraldehydebutyraldehyde results in increased expression of GNA15 mRNA26079696
D002118Calcium[OLFR73 protein co-treated with GNA15 protein] affects the reaction [Eugenol results in increased abundance of Calcium]12767924
C031639caprylic aldehydeGNA15 protein results in increased susceptibility to caprylic aldehyde15598656
C031639caprylic aldehyde[GNA15 protein results in increased susceptibility to caprylic aldehyde] which results in increased activity of OLFR43 protein15598656
C031639caprylic aldehydeGNA15 protein results in increased susceptibility to caprylic aldehyde9875846
C031639caprylic aldehyde[GNA15 protein results in increased susceptibility to caprylic aldehyde] which results in increased activity of OLR226 protein9875846
C006923carvoneGNA15 protein results in increased susceptibility to carvone9875846
C006923carvone[GNA15 protein results in increased susceptibility to carvone] which results in increased activity of OLFR50 protein9875846
C000606134citral dimethyl acetalGNA15 protein results in increased susceptibility to citral dimethyl acetal15598656
C000606134citral dimethyl acetal[GNA15 protein results in increased susceptibility to citral dimethyl acetal] which results in increased activity of OLFR43 protein15598656
C108217citronellalGNA15 protein results in increased susceptibility to citronellal9875846
C108217citronellal[GNA15 protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein9875846
D003471CuprizoneCuprizone results in increased expression of GNA15 mRNA27523638
D003703DemecolcineDemecolcine results in increased expression of GNA15 mRNA23649840
D000431EthanolEthanol results in increased expression of GNA15 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GNA15 mRNA17557909
D005054Eugenol[OLFR73 protein co-treated with GNA15 protein] affects the reaction [Eugenol results in increased abundance of Calcium]12767924
D005419FlavonoidsFlavonoids results in increased expression of GNA15 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of GNA15 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of GNA15 mRNA19167457
C039281furanfuran results in increased expression of GNA15 mRNA27387713
C007836geraniolGNA15 protein results in increased susceptibility to geraniol15598656
C007836geraniol[GNA15 protein results in increased susceptibility to geraniol] which results in increased activity of OLFR43 protein15598656
C046204heptanalGNA15 protein results in increased susceptibility to heptanal9875846
C046204heptanal[GNA15 protein results in increased susceptibility to heptanal] which results in increased activity of OLFR2 protein9875846
D006538Heptanoic AcidsGNA15 protein results in increased susceptibility to Heptanoic Acids15598656
D006538Heptanoic Acids[GNA15 protein results in increased susceptibility to Heptanoic Acids] which results in increased activity of OLFR586 protein15598656
D007545IsoproterenolGNA15 protein results in increased susceptibility to Isoproterenol9875846
D007545Isoproterenol[GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein9875846
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GNA15 mRNA23086925
C008281limoneneGNA15 protein results in increased susceptibility to limonene9875846
C008281limonene[GNA15 protein results in increased susceptibility to limonene] which results in increased activity of OLFR56 protein9875846
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GNA15 mRNA23649840
D009532NickelNickel results in increased expression of GNA15 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of GNA15 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of GNA15 mRNA22714537
C031492octanoic acidGNA15 protein results in increased susceptibility to octanoic acid15598656
C031492octanoic acid[GNA15 protein results in increased susceptibility to octanoic acid] which results in increased activity of OLFR544 protein15598656
C031492octanoic acid[GNA15 protein results in increased susceptibility to octanoic acid] which results in increased activity of OLFR586 protein15598656
C008776pelargonic acidGNA15 protein results in increased susceptibility to pelargonic acid15598656
C008776pelargonic acid[GNA15 protein results in increased susceptibility to pelargonic acid] which results in increased activity of OLFR586 protein15598656
D011374ProgesteroneProgesterone results in decreased expression of GNA15 mRNA19690047
D011794QuercetinQuercetin results in increased expression of GNA15 mRNA15309432
D012999SomanSoman results in increased expression of GNA15 mRNA19281266
D014635Valproic AcidValproic Acid results in increased methylation of GNA15 gene29154799
D014750VincristineVincristine results in increased expression of GNA15 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0001664G-protein coupled receptor binding-IDA10571060  
GO:0003924GTPase activity-IBA21873635  
GO:0005525GTP binding-IEA-  
GO:0031683G-protein beta/gamma-subunit complex binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007202activation of phospholipase C activity-TAS7797501  
GO:0007207phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway-TAS7797501  
GO:0030168platelet activation-TAS-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IPI10571060  
GO:0060158phospholipase C-activating dopamine receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005834heterotrimeric G-protein complex-IBA21873635  
GO:0005834heterotrimeric G-protein complex-NAS10571060  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-109582HemostasisIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-392518Signal amplificationTAS
R-HSA-392518Signal amplificationIEA
R-HSA-399997Acetylcholine regulates insulin secretionTAS
R-HSA-399997Acetylcholine regulates insulin secretionIEA
R-HSA-400451Free fatty acids regulate insulin secretionTAS
R-HSA-400451Free fatty acids regulate insulin secretionIEA
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416476G alpha (q) signalling eventsIEA
R-HSA-418592ADP signalling through P2Y purinoceptor 1TAS
R-HSA-418592ADP signalling through P2Y purinoceptor 1IEA
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-428930Thromboxane signalling through TP receptorTAS
R-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionTAS
R-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionIEA
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28149327In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. (2017)Chatterton ZEpigenetics Chromatin