Gene: GNAL

2774
DYT25
G protein subunit alpha L
protein-coding
18p11.21
Ensembl:ENSG00000141404 MIM:139312 Vega:OTTHUMG00000131660 UniprotKB:P38405
NG_033866.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.167e-1 (AD)  6.373e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs75433892chr18:11712923 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMP50.878
CALB10.87
PCDH80.858
AKAP50.854
DGKB0.848
MPPED20.845
LRRTM10.841
FAM110B0.837
PTPRO0.837
CAMK40.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.519
TGFB3-0.455
ZFP57-0.449
MYL3-0.436
GNG8-0.43
BCAS1-0.426
MYOT-0.425
VRK2-0.42
PAIP2B-0.419
SLCO1A2-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNAL mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNAL mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNAL mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNAL mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNAL mRNA"25510870
C0119172-heptanoneGNAL protein results in increased susceptibility to 2-heptanone15598656
C0119172-heptanone[GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OLFR154 protein15598656
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GNAL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GNAL mRNA"27188386
C496492abrineabrine results in decreased expression of GNAL mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of GNAL mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of GNAL mRNA26690555
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GNAL mRNA]18700144
D000242Cyclic AMP[[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein] which results in increased abundance of Cyclic AMP15598656
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GNAL gene27153756
C512486alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde"GNAL protein results in increased susceptibility to alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde"15598656
C512486alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde"[GNAL protein results in increased susceptibility to alpha-methyl-3,4-methylene-dioxyhydrocinnamic aldehyde] which results in increased activity of OLFR43 protein"15598656
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNAL mRNA16483693
D003913DextroamphetamineGNAL protein results in increased susceptibility to Dextroamphetamine11404425
D001151ArsenicArsenic affects the methylation of GNAL gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of GNAL mRNA15761015
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of GNAL mRNA"25351596
C010038azelaic acidEgtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to azelaic acid]15598656
C010038azelaic acidEgtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein]15598656
C010038azelaic acidGNAL protein results in increased susceptibility to azelaic acid15598656
C010038azelaic acid[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein15598656
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to GNAL promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GNAL mRNA21839799
C006780bisphenol Abisphenol A affects the expression of GNAL mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of GNAL mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GNAL mRNA25181051
C473193bourgeonalGNAL protein results in increased susceptibility to bourgeonal15598656
C473193bourgeonal[GNAL protein results in increased susceptibility to bourgeonal] which results in increased activity of OLFR43 protein15598656
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GNAL mRNA20360939
D002110CaffeineGNAL protein results in increased susceptibility to Caffeine11404425
C031639caprylic aldehydeGNAL protein results in increased susceptibility to caprylic aldehyde15598656
C031639caprylic aldehyde[GNAL protein results in increased susceptibility to caprylic aldehyde] which results in increased activity of OLFR43 protein15598656
C108217citronellalEgtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to citronellal]15598656
C108217citronellalEgtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]15598656
C108217citronellalGNAL protein results in increased susceptibility to citronellal15598656
C108217citronellal[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein15598656
C108217citronellal[[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein] which results in increased abundance of Cyclic AMP15598656
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of GNAL mRNA20971185
D003471CuprizoneCuprizone affects the expression of GNAL mRNA27523638
D003471CuprizoneCuprizone results in increased expression of GNAL mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of GNAL mRNA20106945
C021170decanaldehydeGNAL protein results in increased susceptibility to decanaldehyde15598656
C021170decanaldehyde[GNAL protein results in increased susceptibility to decanaldehyde] which results in increased activity of OLFR43 protein15598656
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GNAL mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GNAL mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GNAL mRNA17379624
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GNAL mRNA20360939
D004533Egtazic AcidEgtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to azelaic acid]15598656
D004533Egtazic AcidEgtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein]15598656
D004533Egtazic AcidEgtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to citronellal]15598656
D004533Egtazic AcidEgtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to citronellal] which results in increased activity of OLFR49 protein]15598656
D004533Egtazic AcidEgtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to Isoproterenol]15598656
D000431EthanolEthanol results in increased expression of GNAL mRNA20655511
C069837fullerene C60fullerene C60 results in decreased expression of GNAL mRNA19167457
C007836geraniolGNAL mRNA promotes the reaction [geraniol results in increased secretion of GCG protein]29070885
C007836geraniolGNAL protein results in increased susceptibility to geraniol15598656
C007836geraniol[GNAL protein results in increased susceptibility to geraniol] which results in increased activity of OLFR43 protein15598656
D007545IsoproterenolEgtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to Isoproterenol]15598656
D007545IsoproterenolGNAL protein results in increased susceptibility to Isoproterenol15598656
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GNAL mRNA26752646
D007854LeadLead affects the expression of GNAL mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GNAL mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GNAL mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GNAL mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GNAL mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of GNAL mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of GNAL mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of GNAL mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNAL mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of GNAL mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GNAL mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of GNAL mRNA24780913
D012293RifampinRifampin results in decreased expression of GNAL mRNA24552687
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GNAL mRNA25351596
D012999SomanSoman results in decreased expression of GNAL mRNA19281266
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of GNAL mRNA26496021
D013849ThimerosalThimerosal results in decreased expression of GNAL mRNA27188386
C012589trichostatin Atrichostatin A results in decreased expression of GNAL mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of GNAL mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of GNAL gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of GNAL mRNA15901671
D014638VanadatesVanadates results in decreased expression of GNAL mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0003924GTPase activity-IBA21873635  
GO:0005525GTP binding-IEA-  
GO:0031683G-protein beta/gamma-subunit complex binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8243272  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS-  
GO:0007608sensory perception of smell-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005834heterotrimeric G-protein complex-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04740Olfactory transduction
hsa05142Chagas disease (American trypanosomiasis)
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-170660Adenylate cyclase activating pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-381753Olfactory Signaling PathwayTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997269Inhibition of adenylate cyclase pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal