Gene: GNAQ

2776
CMC1|G-ALPHA-q|GAQ|SWS
G protein subunit alpha q
protein-coding
9q21.2
Ensembl:ENSG00000156052 MIM:600998 Vega:OTTHUMG00000020059 UniprotKB:P50148
NG_027904.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.465e-1 (AD)  5.211e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PUM20.939
MATR30.932
ARL6IP10.929
BTBD10.926
CALM10.926
UGP20.926
RNF110.925
RPRD1A0.924
TOP2B0.924
EIF4A20.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.798
OR4F29-0.78
TFPI2-0.315
CSAG1-0.272
KLRB1-0.257
TBX21-0.253
C9orf135-0.245
KLRF1-0.243
SLAMF6-0.24
FOLR3-0.24

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GNAQ mRNA"19114083
C5614542,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide"GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide]"22733540
C5614542,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide"[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide]] which results in increased cleavage of CASP3 protein"22733540
C5614542,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide"[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide]] which results in increased cleavage of CASP7 protein"22733540
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of GNAQ mRNA16460773
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]"28751236
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA19191707
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of GNAQ mRNA20829426
C056165acetovanilloneacetovanillone inhibits the reaction [Glucose results in increased expression of GNAQ protein]20691780
C056165acetovanilloneacetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein]20691780
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GNAQ mRNA19770486
D000535AluminumGNAQ protein results in increased susceptibility to Aluminum15068510
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GNAQ mRNA21298039
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GNAQ mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNAQ mRNA16483693
C015001arsenitearsenite results in decreased methylation of GNAQ promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GNAQ mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNAQ mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to GNAQ protein]23665804
D004958EstradiolEstradiol promotes the reaction [GNAQ protein binds to ESR1 protein]27156127
C044887beta-methylcholinebeta-methylcholine affects the expression of GNAQ mRNA21179406
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of GNAQ mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GNAQ mRNA29097150
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of GNAQ mRNA16460773
C584509C646 compoundC646 compound results in decreased expression of GNAQ mRNA26191083
D002110CaffeineCaffeine results in decreased expression of GNAQ protein15998294
D002220CarbamazepineCarbamazepine affects the expression of GNAQ mRNA24752500
C026690cerous chloridecerous chloride results in increased expression of GNAQ mRNA23573234
D004390ChlorpyrifosChlorpyrifos results in increased expression of GNAQ mRNA20350560
C043867cicaprostcicaprost promotes the reaction [PTGIR protein binds to GNAQ protein]11895442
C018021cobaltous chloridecobaltous chloride results in decreased expression of GNAQ mRNA19320972
D003375CoumestrolCoumestrol results in decreased expression of GNAQ mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of GNAQ mRNA19770486
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]28751236
C028972dan-shen root extractdan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]23419388
C028972dan-shen root extractfulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]]23419388
D003976DiazinonDiazinon affects the expression of GNAQ mRNA22546817
D003976DiazinonDiazinon results in decreased expression of GNAQ mRNA17452286
D002945CisplatinCisplatin results in decreased expression of GNAQ mRNA27594783
D004008DiclofenacDiclofenac affects the expression of GNAQ mRNA24752500
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GNAQ mRNA22079256
D000431EthanolEthanol results in increased expression of GNAQ mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GNAQ mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GNAQ mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GNAQ gene16724327
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]25980589
D005473FluoxetineFluoxetine results in increased expression of GNAQ mRNA1426031
C070081fulvestrantfulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]]23419388
D005682GadoliniumGNAQ protein results in increased susceptibility to Gadolinium15068510
C021298ganglioside, GD1a"ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]"21671308
C021298ganglioside, GD1a"ganglioside, GD1a inhibits the reaction [Wasp Venoms results in increased activity of and affects the localization of GNAQ protein]"21671308
D005947Glucoseacetovanillone inhibits the reaction [Glucose results in increased expression of GNAQ protein]20691780
D005947GlucoseCAT protein inhibits the reaction [Glucose results in increased expression of GNAQ protein]20691780
D005947GlucoseGlucose results in increased expression of GNAQ protein20691780
D017313FenretinideFenretinide results in decreased expression of GNAQ mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GNAQ mRNA25613284
C561695(+)-JQ1 compound[BCL2L1 protein co-treated with RAD51 protein] inhibits the reaction [GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound]26397223
C561695(+)-JQ1 compound[BCL2L1 protein co-treated with RAD51 protein] inhibits the reaction [[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased cleavage of PARP1 protein]26397223
C561695(+)-JQ1 compoundGNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of BCL2L1 mRNA26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of BCL2L1 protein26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of BRCA1 protein26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of RAD51 mRNA26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of RAD51 protein26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of WEE1 protein26397223
C561695(+)-JQ1 compound[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased cleavage of PARP1 protein26397223
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [GNAQ gene mutant form promotes the reaction [BRD4 protein binds to BCL2L1 promoter]]26397223
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [GNAQ gene mutant form promotes the reaction [BRD4 protein binds to RAD51 promoter]]26397223
D007854LeadLead affects the expression of GNAQ mRNA28903495
C045463leflunomideleflunomide results in increased expression of GNAQ mRNA28988120
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GNAQ mRNA26378955
C037500mastoparan"ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]"21671308
C037500mastoparanG(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]21671308
C037500mastoparanmastoparan results in increased activity of and affects the localization of GNAQ protein21671308
C004925methylmercuric chloridemethylmercuric chloride affects the expression of GNAQ protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GNAQ protein25809596
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GNAQ mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GNAQ mRNA"20188158
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GNAQ protein modified form]28751236
D005677G(M1) GangliosideG(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]21671308
C022838nickel chloridenickel chloride affects the expression of GNAQ mRNA22546817
C062258Pasteurella multocida toxinPasteurella multocida toxin results in increased metabolism of GNAQ protein26369790
D010634PhenobarbitalPhenobarbital results in decreased expression of GNAQ mRNA23091169
D010656Phenylephrinetyrphostin AG 1478 inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]14676212
D010656PhenylephrineUridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]14676212
D064209PhytochemicalsPhytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]25980589
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GNAQ mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GNAQ mRNA22079256
D011692Puromycin AminonucleosideGNAQ protein results in increased susceptibility to Puromycin Aminonucleoside16267159
D012969Sodium FluorideSodium Fluoride results in decreased expression of GNAQ protein28918527
C060506sphingosine 1-phosphateFingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]25980589
C060506sphingosine 1-phosphatePhytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]25980589
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased expression of GNAQ protein25980589
D013311Streptozocinacetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein]20691780
D013311StreptozocinCAT protein inhibits the reaction [Streptozocin results in increased expression of GNAQ protein]20691780
D013311StreptozocinStreptozocin results in increased expression of GNAQ protein20691780
D013324StrontiumGNAQ protein results in increased susceptibility to Strontium15068510
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of GNAQ mRNA26378955
C061133tamibarotenetamibarotene affects the expression of GNAQ mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNAQ mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GNAQ mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of GNAQ protein15998294
C560077trametinib"GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide]"22733540
C560077trametinib"[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide]] which results in increased cleavage of CASP3 protein"22733540
C560077trametinib"[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with 2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide]] which results in increased cleavage of CASP7 protein"22733540
C560077trametinibGNAQ protein mutant form results in increased susceptibility to trametinib22733540
D014212TretinoinTretinoin results in decreased expression of GNAQ mRNA15498508
C016481trisialoganglioside GT1trisialoganglioside GT1 inhibits the reaction [Wasp Venoms results in increased activity of and affects the localization of GNAQ protein]21671308
C057693troglitazonetroglitazone results in decreased expression of GNAQ mRNA28973697
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]14676212
D014520UrethaneUrethane results in increased expression of GNAQ mRNA28818685
D014544Uridine TriphosphateUridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]14676212
D014635Valproic AcidValproic Acid results in decreased expression of GNAQ mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GNAQ gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride affects the expression of GNAQ mRNA25423262
D014862Wasp Venoms"ganglioside, GD1a inhibits the reaction [Wasp Venoms results in increased activity of and affects the localization of GNAQ protein]"21671308
D014862Wasp Venomstrisialoganglioside GT1 inhibits the reaction [Wasp Venoms results in increased activity of and affects the localization of GNAQ protein]21671308

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IEA-  
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IDA15611106  
GO:0005515protein binding-IPI18672896  22056876  22750945  23353685  27265506  
GO:0005525GTP binding-IEA-  
GO:0031683G-protein beta/gamma-subunit complex binding-IBA21873635  
GO:0031826type 2A serotonin receptor binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IEA-  
GO:0001508action potential-IBA21873635  
GO:0006469negative regulation of protein kinase activity-IMP20399743  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007202activation of phospholipase C activity-TAS8825633  
GO:0007213G-protein coupled acetylcholine receptor signaling pathway-ISS-  
GO:0007215glutamate receptor signaling pathway-IBA21873635  
GO:0007507heart development-IEA-  
GO:0007596blood coagulation-TAS9238049  
GO:0007603phototransduction, visible light-ISS-  
GO:0009649entrainment of circadian clock-ISS-  
GO:0009791post-embryonic development-IEA-  
GO:0016322neuron remodeling-IEA-  
GO:0021884forebrain neuron development-IEA-  
GO:0030168platelet activation-TAS-  
GO:0042711maternal behavior-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045634regulation of melanocyte differentiation-IEA-  
GO:0048066developmental pigmentation-IEA-  
GO:0050821protein stabilization-IMP20399743  
GO:0060828regulation of canonical Wnt signaling pathway-IMP20399743  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-ISS-  
GO:0005737cytoplasm-TAS9175863  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005834heterotrimeric G-protein complex-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0030425dendrite-IEA-  
GO:0031965nuclear membrane-IEA-  
GO:0044297cell body-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)
hsa05143African trypanosomiasis
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-109582HemostasisIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-392518Signal amplificationTAS
R-HSA-392518Signal amplificationIEA
R-HSA-399997Acetylcholine regulates insulin secretionTAS
R-HSA-399997Acetylcholine regulates insulin secretionIEA
R-HSA-400451Free fatty acids regulate insulin secretionTAS
R-HSA-400451Free fatty acids regulate insulin secretionIEA
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416476G alpha (q) signalling eventsIEA
R-HSA-418592ADP signalling through P2Y purinoceptor 1TAS
R-HSA-418592ADP signalling through P2Y purinoceptor 1IEA
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-428930Thromboxane signalling through TP receptorTAS
R-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionTAS
R-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionIEA
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27008846CUSTOM-SEQ: a prototype for oncology rapid learning in a comprehensive EHR environment. (2016 Jul)Warner JLJ Am Med Inform Assoc
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy