Gene: GNB3

2784
CSNB1H
G protein subunit beta 3
protein-coding
12p13.31
Ensembl:ENSG00000111664 MIM:139130 Vega:OTTHUMG00000168517 UniprotKB:P16520
NG_009100.1
PubMed
OD|ND|AD
21   
9.407e-1 (AD)  7.501e-1 (ND)   (Frontal_Cortex)
7.541e-1 (AD)  1.847e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDCA30.865
ZGLP10.843
TNFRSF250.828
ATXN7L20.817
RCE10.815
QRICH20.801
FGF170.801
HIC20.799
GSDMB0.783
PRSS530.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE11A-0.373
TRDN-0.356
PHEX-0.338
AGTR1-0.336
LRRCC1-0.332
OR4F5-0.328
CRYBG3-0.316
PPP1R42-0.311
MBNL3-0.31
CD48-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of GNB3 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNB3 mRNA16483693
D001280AtrazineAtrazine results in increased expression of GNB3 mRNA22378314
D001464Barium[GNB3 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB3 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D001464Barium[GNB3 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]11007869
D004958EstradiolEstradiol promotes the reaction [GNB3 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A results in decreased expression of GNB3 mRNA25181051
D003024ClozapineGNB3 gene polymorphism results in decreased susceptibility to Clozapine18855531
D003024ClozapineGNB3 gene polymorphism results in increased susceptibility to Clozapine16139171
D003024ClozapineGNB3 protein affects the susceptibility to Clozapine18855531
D003024ClozapineClozapine results in increased expression of GNB3 protein16141801
D003561CytarabineCytarabine results in decreased expression of GNB3 mRNA21198554
C544151jinfukangjinfukang results in increased expression of GNB3 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of GNB3 mRNA28988120
D008055LipidsGNB3 gene polymorphism affects the metabolism of Lipids11978662
D008694MethamphetamineMethamphetamine results in decreased expression of GNB3 protein19826936
D005996NitroglycerinGNB3 protein affects the susceptibility to Nitroglycerin14586390
D009661NortriptylineGNB3 gene polymorphism results in decreased susceptibility to Nortriptyline14604448
D009661NortriptylineGNB3 protein results in increased susceptibility to Nortriptyline14604448
D052638Particulate MatterParticulate Matter results in decreased expression of GNB3 mRNA17987463
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"25510870
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GNB3 mRNA23608068
C089730rosiglitazonerosiglitazone affects the expression of GNB3 protein19556978
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GNB3 mRNA25895662
D012834SilverSilver results in increased expression of GNB3 mRNA27131904
C080703SK&F 83959SK&F 83959 results in decreased expression of GNB3 protein25852303
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GNB3 mRNA21570461
C012589trichostatin Atrichostatin A results in decreased expression of GNB3 mRNA15901671
D014520UrethaneUrethane results in decreased expression of GNB3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of GNB3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GNB3 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of GNB3 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of GNB3 mRNA17987463
C025643vinclozolinvinclozolin results in increased expression of GNB3 mRNA15686871

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-TAS9425898  
GO:0005515protein binding-IPI23773523  
GO:0030507spectrin binding-IEA-  
GO:0051020GTPase binding-IPI19255495  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-TAS-  
GO:0006884cell volume homeostasis-IGI29206867  
GO:0007186G-protein coupled receptor signaling pathway-TAS2107550  
GO:0008217regulation of blood pressure-TAS9425898  
GO:0010468regulation of gene expression-IGI29206867  
GO:0010906regulation of glucose metabolic process-IGI29206867  
GO:0032350regulation of hormone metabolic process-IGI29206867  
GO:0045598regulation of fat cell differentiation-IGI29206867  
GO:0060259regulation of feeding behaviorNOTIGI29206867  
GO:0090181regulation of cholesterol metabolic process-IGI29206867  
GO:0090207regulation of triglyceride metabolic process-IGI29206867  
GO:0090325regulation of locomotion involved in locomotory behaviorNOTIGI29206867  
GO:1903725regulation of phospholipid metabolic process-IGI29206867  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0030425dendrite-IEA-  
GO:0044297cell body-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04742Taste transduction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-109582HemostasisTAS
R-HSA-111885Opioid SignallingTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1296041Activation of G protein gated Potassium channelsTAS
R-HSA-1296059G protein gated Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163359Glucagon signaling in metabolic regulationTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-202040G-protein activationTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionTAS
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionIEA
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390466Chaperonin-mediated protein foldingTAS
R-HSA-391251Protein foldingTAS
R-HSA-392170ADP signalling through P2Y purinoceptor 12TAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392518Signal amplificationTAS
R-HSA-392518Signal amplificationIEA
R-HSA-392851Prostacyclin signalling through prostacyclin receptorIEA
R-HSA-392851Prostacyclin signalling through prostacyclin receptorTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionTAS
R-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionIEA
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-4086398Ca2+ pathwayIEA
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-418217G beta:gamma signalling through PLC betaTAS
R-HSA-418346Platelet homeostasisIEA
R-HSA-418346Platelet homeostasisTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418592ADP signalling through P2Y purinoceptor 1TAS
R-HSA-418592ADP signalling through P2Y purinoceptor 1IEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418597G alpha (z) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-428930Thromboxane signalling through TP receptorTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-451326Activation of kainate receptors upon glutamate bindingTAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)TAS
R-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)IEA
R-HSA-500657Presynaptic function of Kainate receptorsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27110136Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan. (2016)Harada MInt J Gen Med
19597293A splice variant of GNB3 and peripheral polyneuropathy in type 1 diabetes. (2009)Chistiakov DADis Markers
18551105Interaction of G-protein beta3 subunit and nitric oxide synthase gene polymorphisms on carotid artery intima-media thickness in young adults: the Bogalusa Heart Study. (2008 Aug)Bhuiyan ARAm J Hypertens
25510251GNB3 and FTO Polymorphisms and Pregnancy Weight Gain in Black Women. (2015 Jul)Groth SWBiol Res Nurs
12724620Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction. (2003 May)Naber CKPharmacogenetics
18990763Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma. (2008 Nov)Lehnerdt GFCancer Epidemiol Biomarkers Prev
17036337Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (2006 Nov 15)Carmichael SLAm J Med Genet A
15855877Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. (2005 Apr)Kiani JGNeuro Endocrinol Lett
25860557Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment. (2015 Apr)Cui HCardiovasc Drugs Ther
21675276[A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors]. (2011)Polonikov AVTer Arkh
15614196G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. (2005 Jan)Mahmood MSMed Sci Monit
23595158Association of the G-protein beta3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study. (2013 Oct)Daimon MJ Hum Hypertens
16897596The GNB3 C825T polymorphism and depression among subjects with alcohol dependence. (2007)Prestes APJ Neural Transm (Vienna)
16133558Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer. (2005 Sep)Eisenhardt AWorld J Urol
12818251Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation. (2003 Mar 15)Frey UHThromb Res
16713434G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males--a prospective study over 5 years. (2006 Jun)Suwazono YMetabolism
12439636[Genetic factors in myocardial infarction--Results from a candidate gene and a genome-wide approach between beta blockers]. (2002 Nov)Hengstenberg CHerz
19303909Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene. (2009 Jun 15)Lieb BProg Neuropsychopharmacol Biol Psychiatry
29469022Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women. (2018 Apr)Groth SWNutrition
19193342Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (2008 Sep)Ujike HJ Clin Psychiatry
27616475Gene variants as risk factors for gastroschisis. (2016 Nov)Padula AMAm J Med Genet A