Gene info: ID 2784

Gene: GNB3

GENE ID: 2784

Synonyms: CSNB1H

Description: G protein subunit beta 3

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000111664 MIM:139130 Vega:OTTHUMG00000168517 UniprotKB:P16520

RefSeq: NG_009100.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 21

Sherlock p-value : 9.407e-1 (AD) 7.501e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.541e-1 (AD) 1.847e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDCA3	0.865
ZGLP1	0.843
TNFRSF25	0.828
ATXN7L2	0.817
RCE1	0.815
QRICH2	0.801
FGF17	0.801
HIC2	0.799
GSDMB	0.783
PRSS53	0.779

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDE11A	-0.373
TRDN	-0.356
PHEX	-0.338
AGTR1	-0.336
LRRCC1	-0.332
OR4F5	-0.328
CRYBG3	-0.316
PPP1R42	-0.311
MBNL3	-0.31
CD48	-0.309

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"	25510870
D000082	Acetaminophen	Acetaminophen affects the expression of GNB3 mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GNB3 mRNA	16483693
D001280	Atrazine	Atrazine results in increased expression of GNB3 mRNA	22378314
D001464	Barium	[GNB3 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]	11007869
D001464	Barium	[GNB3 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]	11007869
D001464	Barium	[GNB3 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]	11007869
D004958	Estradiol	Estradiol promotes the reaction [GNB3 protein binds to ESR1 protein]	27156127
C006780	bisphenol A	bisphenol A results in decreased expression of GNB3 mRNA	25181051
D003024	Clozapine	GNB3 gene polymorphism results in decreased susceptibility to Clozapine	18855531
D003024	Clozapine	GNB3 gene polymorphism results in increased susceptibility to Clozapine	16139171
D003024	Clozapine	GNB3 protein affects the susceptibility to Clozapine	18855531
D003024	Clozapine	Clozapine results in increased expression of GNB3 protein	16141801
D003561	Cytarabine	Cytarabine results in decreased expression of GNB3 mRNA	21198554
C544151	jinfukang	jinfukang results in increased expression of GNB3 mRNA	27392435
C045463	leflunomide	leflunomide results in decreased expression of GNB3 mRNA	28988120
D008055	Lipids	GNB3 gene polymorphism affects the metabolism of Lipids	11978662
D008694	Methamphetamine	Methamphetamine results in decreased expression of GNB3 protein	19826936
D005996	Nitroglycerin	GNB3 protein affects the susceptibility to Nitroglycerin	14586390
D009661	Nortriptyline	GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline	14604448
D009661	Nortriptyline	GNB3 protein results in increased susceptibility to Nortriptyline	14604448
D052638	Particulate Matter	Particulate Matter results in decreased expression of GNB3 mRNA	17987463
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GNB3 mRNA"	25510870
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GNB3 mRNA	23608068
C089730	rosiglitazone	rosiglitazone affects the expression of GNB3 protein	19556978
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of GNB3 mRNA	25895662
D012834	Silver	Silver results in increased expression of GNB3 mRNA	27131904
C080703	SK&F 83959	SK&F 83959 results in decreased expression of GNB3 protein	25852303
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GNB3 mRNA	21570461
C012589	trichostatin A	trichostatin A results in decreased expression of GNB3 mRNA	15901671
D014520	Urethane	Urethane results in decreased expression of GNB3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased methylation of GNB3 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of GNB3 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in decreased expression of GNB3 mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of GNB3 mRNA	17987463
C025643	vinclozolin	vinclozolin results in increased expression of GNB3 mRNA	15686871

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	TAS	9425898
GO:0005515	protein binding	-	IPI	23773523
GO:0030507	spectrin binding	-	IEA	-
GO:0051020	GTPase binding	-	IPI	19255495

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006457	protein folding	-	TAS	-
GO:0006884	cell volume homeostasis	-	IGI	29206867
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	2107550
GO:0008217	regulation of blood pressure	-	TAS	9425898
GO:0010468	regulation of gene expression	-	IGI	29206867
GO:0010906	regulation of glucose metabolic process	-	IGI	29206867
GO:0032350	regulation of hormone metabolic process	-	IGI	29206867
GO:0045598	regulation of fat cell differentiation	-	IGI	29206867
GO:0060259	regulation of feeding behavior	NOT	IGI	29206867
GO:0090181	regulation of cholesterol metabolic process	-	IGI	29206867
GO:0090207	regulation of triglyceride metabolic process	-	IGI	29206867
GO:0090325	regulation of locomotion involved in locomotory behavior	NOT	IGI	29206867
GO:1903725	regulation of phospholipid metabolic process	-	IGI	29206867

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0030425	dendrite	-	IEA	-
GO:0044297	cell body	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway
hsa04742	Taste transduction

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1296041	Activation of G protein gated Potassium channels	TAS
R-HSA-1296059	G protein gated Potassium channels	TAS
R-HSA-1296065	Inwardly rectifying K+ channels	TAS
R-HSA-1296071	Potassium Channels	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163359	Glucagon signaling in metabolic regulation	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-202040	G-protein activation	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	IEA
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390466	Chaperonin-mediated protein folding	TAS
R-HSA-391251	Protein folding	TAS
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392518	Signal amplification	TAS
R-HSA-392518	Signal amplification	IEA
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	IEA
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	TAS
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	IEA
R-HSA-400508	Incretin synthesis, secretion, and inactivation	TAS
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-4086398	Ca2+ pathway	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-418217	G beta:gamma signalling through PLC beta	TAS
R-HSA-418346	Platelet homeostasis	IEA
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	TAS
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	IEA
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-418597	G alpha (z) signalling events	TAS
R-HSA-420092	Glucagon-type ligand receptors	TAS
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-428930	Thromboxane signalling through TP receptor	TAS
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	TAS
R-HSA-445717	Aquaporin-mediated transport	TAS
R-HSA-451326	Activation of kainate receptors upon glutamate binding	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	IEA
R-HSA-500657	Presynaptic function of Kainate receptors	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	IEA
R-HSA-977443	GABA receptor activation	TAS
R-HSA-977444	GABA B receptor activation	TAS
R-HSA-991365	Activation of GABAB receptors	TAS
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27110136	Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan. (2016)	Harada M	Int J Gen Med
19597293	A splice variant of GNB3 and peripheral polyneuropathy in type 1 diabetes. (2009)	Chistiakov DA	Dis Markers
18551105	Interaction of G-protein beta3 subunit and nitric oxide synthase gene polymorphisms on carotid artery intima-media thickness in young adults: the Bogalusa Heart Study. (2008 Aug)	Bhuiyan AR	Am J Hypertens
25510251	GNB3 and FTO Polymorphisms and Pregnancy Weight Gain in Black Women. (2015 Jul)	Groth SW	Biol Res Nurs
12724620	Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction. (2003 May)	Naber CK	Pharmacogenetics
18990763	Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma. (2008 Nov)	Lehnerdt GF	Cancer Epidemiol Biomarkers Prev
17036337	Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (2006 Nov 15)	Carmichael SL	Am J Med Genet A
15855877	Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. (2005 Apr)	Kiani JG	Neuro Endocrinol Lett
25860557	Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment. (2015 Apr)	Cui H	Cardiovasc Drugs Ther
21675276	[A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors]. (2011)	Polonikov AV	Ter Arkh
15614196	G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. (2005 Jan)	Mahmood MS	Med Sci Monit
23595158	Association of the G-protein beta3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study. (2013 Oct)	Daimon M	J Hum Hypertens
16897596	The GNB3 C825T polymorphism and depression among subjects with alcohol dependence. (2007)	Prestes AP	J Neural Transm (Vienna)
16133558	Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer. (2005 Sep)	Eisenhardt A	World J Urol
12818251	Cooperative effect of GNB3 825C>T and GPIIIa PI(A) polymorphisms in enhanced platelet aggregation. (2003 Mar 15)	Frey UH	Thromb Res
16713434	G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males--a prospective study over 5 years. (2006 Jun)	Suwazono Y	Metabolism
12439636	[Genetic factors in myocardial infarction--Results from a candidate gene and a genome-wide approach between beta blockers]. (2002 Nov)	Hengstenberg C	Herz
19303909	Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene. (2009 Jun 15)	Lieb B	Prog Neuropsychopharmacol Biol Psychiatry
29469022	Obesity candidate genes, gestational weight gain, and body weight changes in pregnant women. (2018 Apr)	Groth SW	Nutrition
19193342	Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (2008 Sep)	Ujike H	J Clin Psychiatry
27616475	Gene variants as risk factors for gastroschisis. (2016 Nov)	Padula AM	Am J Med Genet A