Gene info: ID 2788

Gene: GNG7

GENE ID: 2788

Synonyms: -

Description: G protein subunit gamma 7

Gene type: protein-coding

Location: 19p13.3

dbXrefs: Ensembl:ENSG00000176533 MIM:604430 Vega:OTTHUMG00000180435 UniprotKB:O60262

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.737e-1 (AD) 3.886e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg10181414	chr19:2546598	GNG7		1.900e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PALM	0.835
ST6GALNAC6	0.828
SLC25A23	0.795
SLC25A6	0.793
SMARCD3	0.792
WDR13	0.788
EEF2	0.787
PACS2	0.787
DVL1	0.782
FAM102A	0.778

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.745
OR4F29	-0.717
IL15	-0.263
CD80	-0.259
CYP19A1	-0.244
OR52N4	-0.239
CR1L	-0.238
GBP5	-0.238
IL27	-0.238
CEACAM1	-0.237

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNG7 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNG7 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNG7 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNG7 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNG7 mRNA"	25510870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG7 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG7 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in increased expression of GNG7 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GNG7 mRNA	21641981
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GNG7 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of GNG7 gene	25304211
D001374	Azacitidine	Azacitidine affects the methylation of GNG7 promoter	18219292
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GNG7 mRNA	21632981\|2187194
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GNG7 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNG7 mRNA"	26238291
C006780	bisphenol A	bisphenol A affects the expression of GNG7 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of GNG7 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of GNG7 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of GNG7 promoter	22457795
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GNG7 gene	20938992
C014986	cyanobacterial toxin	cyanobacterial toxin results in decreased expression of GNG7 protein	22872059
C014347	decitabine	decitabine affects the expression of GNG7 mRNA	23300844
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of GNG7 mRNA	28962523
D002945	Cisplatin	Cisplatin affects the expression of GNG7 mRNA	23300844
C058705	diethyl malate	diethyl malate affects the expression of GNG7 mRNA	24814887
C118739	entinostat	entinostat results in increased expression of GNG7 mRNA	27188386
D000431	Ethanol	Ethanol results in increased expression of GNG7 mRNA	20655511
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of GNG7 mRNA	23649840
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GNG7 gene	20938992
D004397	Fonofos	Fonofos results in increased methylation of GNG7 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of GNG7 mRNA	23649840
C039281	furan	furan results in increased methylation of GNG7 gene	22079235
C546771	gardiquimod	gardiquimod results in decreased expression of GNG7 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GNG7 mRNA]	28003376
D019833	Genistein	Genistein results in increased expression of GNG7 mRNA	18847459
C492448	ICG 001	ICG 001 results in decreased expression of GNG7 mRNA	26191083
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of GNG7 mRNA	20353558
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GNG7 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GNG7 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of GNG7 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of GNG7 mRNA	24810058
D009532	Nickel	Nickel results in decreased expression of GNG7 mRNA	25583101
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of GNG7 mRNA	12102619
D010278	Parathion	Parathion results in increased methylation of GNG7 promoter	22847954
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GNG7 mRNA"	25510870
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG7 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of GNG7 mRNA	26272509
D059808	Polyphenols	Polyphenols results in decreased expression of GNG7 mRNA	16293270
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of GNG7 mRNA	23608068
C005556	propionaldehyde	propionaldehyde results in increased expression of GNG7 mRNA	26079696
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GNG7 mRNA]	28003376
C513428	pyrachlostrobin	pyrachlostrobin results in decreased expression of GNG7 mRNA	27029645
D012715	Sesame Oil	Sesame Oil results in increased expression of GNG7 mRNA	29191790
C017947	sodium arsenite	sodium arsenite affects the methylation of GNG7 gene	28589171
C012568	terbufos	terbufos results in increased methylation of GNG7 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GNG7 mRNA	24680724
D013849	Thimerosal	Thimerosal results in decreased expression of GNG7 mRNA	27188386
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of GNG7 gene	27618143
C012589	trichostatin A	trichostatin A affects the expression of GNG7 mRNA	28542535
D014635	Valproic Acid	Valproic Acid affects the expression of GNG7 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of GNG7 mRNA	28001369\|2915479
C088658	zoledronic acid	zoledronic acid results in decreased expression of GNG7 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001662	behavioral fear response	-	IBA	21873635
GO:0007168	receptor guanylyl cyclase signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007626	locomotory behavior	-	IBA	21873635
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	-	TAS	9600093
GO:0045761	regulation of adenylate cyclase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005834	heterotrimeric G-protein complex	-	IBA	21873635
GO:0005834	heterotrimeric G-protein complex	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145

KEGG ID	KEGG Term
hsa04062	Chemokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1296041	Activation of G protein gated Potassium channels	TAS
R-HSA-1296059	G protein gated Potassium channels	TAS
R-HSA-1296065	Inwardly rectifying K+ channels	TAS
R-HSA-1296071	Potassium Channels	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163359	Glucagon signaling in metabolic regulation	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-202040	G-protein activation	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390466	Chaperonin-mediated protein folding	TAS
R-HSA-391251	Protein folding	TAS
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392518	Signal amplification	TAS
R-HSA-392518	Signal amplification	IEA
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	IEA
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	TAS
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	IEA
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-4086398	Ca2+ pathway	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-418217	G beta:gamma signalling through PLC beta	TAS
R-HSA-418346	Platelet homeostasis	IEA
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	TAS
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	IEA
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-418597	G alpha (z) signalling events	TAS
R-HSA-420092	Glucagon-type ligand receptors	TAS
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-428930	Thromboxane signalling through TP receptor	TAS
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	TAS
R-HSA-445717	Aquaporin-mediated transport	TAS
R-HSA-451326	Activation of kainate receptors upon glutamate binding	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	IEA
R-HSA-500657	Presynaptic function of Kainate receptors	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	IEA
R-HSA-977443	GABA receptor activation	TAS
R-HSA-977444	GABA B receptor activation	TAS
R-HSA-991365	Activation of GABAB receptors	TAS
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26455281	Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)	Stankiewicz AM	Pharmacol Biochem Behav