Gene: GNRH2

2797
GnRH-II|LH-RHII
gonadotropin releasing hormone 2
protein-coding
20p13
Ensembl:ENSG00000125787 MIM:602352 Vega:OTTHUMG00000031723 UniprotKB:O43555
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.384e-2 (AD)  9.022e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8125955chr20:3039311 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH20.655
POLN0.652
RAD54L0.63
C15orf620.623
CDCA30.609
HIC20.602
PRSS530.596
ZFHX20.589
HAS30.587
GLIS10.586

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDNF-0.321
MBNL3-0.302
HMGN5-0.301
HSD17B8-0.299
GCSH-0.295
KLRC3-0.294
PROK2-0.294
CCDC102B-0.292
MYL3-0.291
XPNPEP2-0.29

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of GNRH2 mRNA"25723718
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GNRH2 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of GNRH2 mRNA20458559
C015001arsenitearsenite results in increased methylation of GNRH2 promoter23974009
D004958EstradiolEstradiol results in decreased expression of GNRH2 mRNA22497783
C006780bisphenol Abisphenol A results in decreased expression of GNRH2 mRNA22497783
C000611646bisphenol Fbisphenol F results in increased expression of GNRH2 mRNA28741210
C018475butyraldehydebutyraldehyde results in increased expression of GNRH2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GNRH2 mRNA19781795
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GNRH2 mRNA24763279
D019327Copper SulfateCopper Sulfate results in decreased expression of GNRH2 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of GNRH2 mRNA19789285
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GNRH2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GNRH2 mRNA27392435
D005485FlutamideFlutamide results in decreased expression of GNRH2 mRNA24992288
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GNRH2 mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GNRH2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GNRH2 mRNA27392435
D008550MelatoninMelatonin inhibits the reaction [GNRH2 protein results in increased secretion of LHB protein]19093727
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GNRH2 mRNA23458150
C025256nonylphenolnonylphenol results in decreased expression of GNRH2 mRNA22497783
D010126Ozone[Ozone co-treated with Water Pollutants] results in increased expression of GNRH2 mRNA22856545
C046012pentanalpentanal results in increased expression of GNRH2 mRNA26079696
C031181phenanthrenephenanthrene results in increased expression of GNRH2 mRNA19781795
C014925RMI 12330ARMI 12330A inhibits the reaction [GNRH2 protein results in increased secretion of LHB protein]19093727
D012643SeleniumSelenium results in increased expression of GNRH2 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GNRH2 mRNA16267337
D014212TretinoinTretinoin results in increased expression of GNRH2 mRNA15977162
D014260TriclosanTriclosan results in increased expression of GNRH2 mRNA29032082
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of GNRH2 mRNA23603146
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of GNRH2 mRNA23603146
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GNRH2 mRNA"23603146
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GNRH2 mRNA"23603146|2563791
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GNRH2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of GNRH2 mRNA27912163
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of GNRH2 mRNA27131816
D014873Water Pollutants[Ozone co-treated with Water Pollutants] results in increased expression of GNRH2 mRNA22856545

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IEA-  
GO:0005183gonadotropin hormone-releasing hormone activity-IBA21873635  
GO:0031530gonadotropin-releasing hormone receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000003reproduction-IBA21873635  
GO:0007165signal transduction-TAS9419371  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007275multicellular organism development-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04912GnRH signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375281Hormone ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal