Gene: ABO

28
A3GALNT|A3GALT1|GTB|NAGAT
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
protein-coding
9q34.2
Ensembl:ENSG00000175164 MIM:110300 UniprotKB:P16442
NG_006669.1
PubMed|SNP Mapped
ND|AD
85   
8.153e-1 (AD)  1.571e-1 (ND)   (Frontal_Cortex)
4.275e-1 (AD)  9.393e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZC3HAV1L0.505
BTBD190.479
NID20.477
MEGF60.467
GCNT10.458
WWC20.45
FUT40.45
TAF10.449
COL18A10.448
SMC40.442

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MPC1L-0.228
SLC25A48-0.214
BGLAP-0.204
IGLL1-0.193
IL9-0.191
TRIM51-0.19
FOXD4L6-0.189
MUC12-0.188
ACOT6-0.186
MEIG1-0.184

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02196Uridine-Diphosphate-N-AcetylgalactosamineSmall MoleculeExperimentalTarget
DB03435Uridine-5'-DiphosphateSmall Molecule58-98-0ExperimentalTarget
DB03501Galactose-uridine-5'-diphosphateSmall Molecule2956-16-3ExperimentalTarget
DB037722-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,5-DiolSmall MoleculeExperimentalTarget
DB041412-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB04678H TYPE II TRISACCHARIDESmall MoleculeExperimentalTarget
DB04679H TYPE I TRISACCHARIDESmall MoleculeExperimentalTarget
DB04680GALACTOSE GREASESmall MoleculeExperimentalTarget
DB04681BETA-METHYLLACTOSIDESmall MoleculeExperimentalTarget
DB07341octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranosideSmall MoleculeExperimentalTarget
DB073574-AMINO-2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOLSmall MoleculeExperimentalTarget
DB073784-AMINO-2-OCTYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOLSmall MoleculeExperimentalTarget
DB07633octyl 3-deoxy-2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-xylo-hexopyranosideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ABO mRNA"27291303
D000082AcetaminophenAcetaminophen results in decreased expression of ABO mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of ABO mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABO mRNA16483693
C006780bisphenol Abisphenol A results in increased expression of ABO mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ABO promoter22457795
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ABO mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of ABO mRNA21852083
D005419FlavonoidsFlavonoids results in decreased expression of ABO mRNA18035473
C039281furanfuran results in increased expression of ABO mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of ABO mRNA22061828
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ABO mRNA26752646
C500085muraglitazarmuraglitazar results in increased expression of ABO mRNA21515302
D010433PentylenetetrazolePentylenetetrazole affects the expression of ABO mRNA21503142
C089730rosiglitazonerosiglitazone results in increased expression of ABO mRNA21515302
C501413tesaglitazartesaglitazar results in increased expression of ABO mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABO mRNA21570461
C057693troglitazonetroglitazone results in increased expression of ABO mRNA21515302
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ABO gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-IMP12198488  
GO:0003823antigen binding-IMP12198488  
GO:0004380glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity-IBA21873635  
GO:0004380glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity-IEA-  
GO:0004381fucosylgalactoside 3-alpha-galactosyltransferase activity-IEA-  
GO:0016757transferase activity, transferring glycosyl groups-IBA21873635  
GO:0030145manganese ion binding-IMP12198488  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006486protein glycosylation-IEA-  
GO:0030259lipid glycosylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0031982vesicle-IBA21873635  
GO:0032580Golgi cisterna membrane-IEA-  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
979280Lack of association of genetic traits with alcoholism; C3, Ss and ABO systems. (1976 Sep)Winokur GJ Stud Alcohol
3627295Biological markers for alcoholism: a vulnerability model conceptualization. (1986)Hill SYNebr Symp Motiv
26411553Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center. (2015 Sep 28)Li NChin J Cancer
25600007ABO blood types and cancer risk--a cohort study of 339,432 subjects in Taiwan. (2015 Apr)Sun WCancer Epidemiol
29669506Mutations and Common Polymorphisms in ADAMTS13 and vWF Genes Responsible for Increasing Risk of Thrombosis. (2018 Apr 18)Haybar HCardiovasc Hematol Disord Drug Targets
3236886Association of HLA antigens with alcoholic disease. (1988 Nov)Corsico RJ Stud Alcohol
26652818[Association between ABO blood group and acute myocardial infarction]. (2015 Sep)Hu XZhonghua Xin Xue Guan Bing Za Zhi
26652819[Association between ABO blood groups and coronary heart disease in Chinese Guangxi Zhuang population]. (2015 Sep)Shi YZhonghua Xin Xue Guan Bing Za Zhi
25854361Association between ABO genotype and risk of hepatocellular carcinoma in Koreans. (2015)Shim HJAsian Pac J Cancer Prev
21556549Serum placental-type alkaline-phosphatase levels in patients with epithelial ovarian-carcinoma. (1995 Feb)Ind TInt J Oncol
25843264Sources of variation analysis and derivation of reference intervals for ALP, LDH, and amylase isozymes using sera from the Asian multicenter study on reference values. (2015 Jun 15)Shimizu YClin Chim Acta
8288267ABO and rhesus blood groups and adverse outcomes of pregnancy. (1993 Nov-Dec)Linn SHum Hered
9135515Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. (1997 Mar)Parsonnet JGut
3485586Genetic-environmental interactions in chronic airways obstruction. (1986 Mar)Khoury MJInt J Epidemiol
2846954Debrisoquine hydroxylation phenotype, acetylation phenotype, and ABO blood groups as genetic host factors of lung cancer risk. (1988)Roots IKlin Wochenschr
1875761[Pancreatic cancer and ABO blood types: a study of cases and controls]. (1991 May 25)Vioque JMed Clin (Barc)
21258973New developments in pancreatic cancer. (2011 Apr)Greer JBCurr Gastroenterol Rep
20647474New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts. (2010 Sep 1)Li DClin Cancer Res
6610878Risk factors, pulmonary function, and mortality. (1984)Menkes HAProg Clin Biol Res
25726048Demographics, epidemiology, and inheritance of pancreatic ductal adenocarcinoma. (2015 Feb)Yeo TPSemin Oncol
18789630Wine intake, ABO phenotype, and risk of ischemic heart disease and all-cause mortality: the Copenhagen Male Study--a 16-year follow-up. (2008 Nov)Suadicani PAlcohol
26049860Detectable Symptomatology Preceding the Diagnosis of Pancreatic Cancer and Absolute Risk of Pancreatic Cancer Diagnosis. (2015 Jul 1)Risch HAAm J Epidemiol
23786968What is the phenotype of patients with gastrointestinal intolerance to metformin? (2013 Sep)Hermans MPDiabetes Metab
16551818Rhesus positivity and low high-density lipoprotein cholesterol: a new link? (2006 Apr)Kanbay MAsian Cardiovasc Thorac Ann
2088127ABO blood group differences in bone mineral density of recovering alcoholic males. (1990 Dec)Davidson BJAlcohol Clin Exp Res
22842241Relationship between ABO blood groups and oral cancer. (2012 Jan-Feb)Jaleel BFIndian J Dent Res
4759077Peptic ulcer--its association with ABO blood groups, secretor status and smoking habits. (1973 Jul 16)Dutta RNJ Indian Med Assoc
12839286Difference in plasma bilirubin concentration between monozygotic and dizygotic newborn twins. (2003 May)Ebbesen FActa Paediatr
22162228Genetic susceptibility to pancreatic cancer. (2012 Jan)Klein APMol Carcinog
27584569Association of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity. (2016)Song JPLoS One
20103627Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. (2010 Feb 1)Wolpin BMCancer Res
300564Risk factors in chronic obstructive pulmonary disease (COPD). (1977 Mar)Cohen BHAm J Epidemiol
22841339ABO blood group and risk of renal cell cancer. (2012 Dec)Joh HKCancer Epidemiol
13880225Comparison of smokers and non-smokers. II. The distribution of ABO and Rh (D) blood groups. (1962 Jan)COHEN BHBull Johns Hopkins Hosp
22821093Association of blood group A with coronary artery disease in young adults in Taiwan. (2012)Lee HFIntern Med
25400980Helicobacter pylori and pancreatic diseases. (2014 Nov 15)Bulajic MWorld J Gastrointest Pathophysiol
3879571A study of multiple biological markers in twins. (1985)Anton-Guirgis HActa Genet Med Gemellol (Roma)
2517910The influence of ABO blood groups, Rh antigens and cigarette smoking on the level of NK activity in normal population. (1989)Lasek WArch Immunol Ther Exp (Warsz)
21390144Perinatal and early life risk factors for inflammatory bowel disease. (2011 Feb 14)Roberts SEWorld J Gastroenterol
24786325Disease risk factors identified through shared genetic architecture and electronic medical records. (2014 Apr 30)Li LSci Transl Med
23389798ABO blood group and nasopharyngeal carcinoma risk in a population of Southeast China. (2013 Aug 15)Sheng LInt J Cancer
1617824Coronary heart disease risk factors in Hansen's disease sufferers. (1992 Jun)Diamantopoulos EJClin Cardiol
13512206[Correlation of ABO blood groups with alcoholism]. (1958)ACHTE KDuodecim
25592833Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study. (2015 Jan 15)Etemadi ABMC Med
3610457ABO blood group system and cigarette smoking: interaction in chronic airways obstruction. (1987 Jun)Krzyzanowski MInt J Epidemiol
3471027Genetic and metabolic risk factors for the development of late complications in type I (insulin-dependent) diabetes. (1986 Oct-Dec)Pontiroli AEActa Diabetol Lat
26499147[Study on prognosis relationship between ABO blood groups of patients with gastric cancer]. (2015 Oct)Xiao SZhonghua Wei Chang Wai Ke Za Zhi
25940357Relationship of ABO Blood Type on Rotator Cuff Tears. (2015 Nov)Lee DHPM R
1422760Smoking predisposes to parotid adenolymphoma. (1992 Sep)Cadier MBr J Surg
10048726Genetic and life-style determinants of peptic ulcer. A study of 3387 men aged 54 to 74 years: The Copenhagen Male Study. (1999 Jan)Suadicani PScand J Gastroenterol
21839572Effect of smoking and ABO blood groups on maternal age at child bearing and on birth weight. (2011 Nov)Gloria-Bottini FEur J Obstet Gynecol Reprod Biol
15051775Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia. (2004 Apr 1)Robien KJ Clin Oncol
28283105Perinatal characteristics and obstetric complications in mothers with multiple sclerosis: Record-linkage study. (2017 Feb)Goldacre AMult Scler Relat Disord
17154335Is there an association between maternal ABO and rhesus blood groups and the first-trimester serum markers free beta-hCG and PAPP-A used for the detection of fetal aneuploidy? (2007 Jan)Cowans NJPrenat Diagn
24516588Incidence and metastasis of cutaneous malignant melanoma with respect to ABO blood groups: a case-controlled study in northeast of China. (2014)Chang LPLoS One
4696532The relation between gastric acid secretion and body habitus, blood groups, smoking, and the subsequent development of dyspepsia and duodenal ulcer. (1973 Feb)Novis BHGut
11427638Endothelial dysfunction marker von Willebrand factor antigen in haemodialysis patients: associations with pre-dialysis blood pressure and the acute phase response. (2001 Jul)Borawski JNephrol Dial Transplant
11006899Socioeconomic status, ABO phenotypes and risk of ischaemic heart disease: an 8-year follow-up in the Copenhagen Male Study. (2000 Aug)Suadicani PJ Cardiovasc Risk
6783879[Blood group, alcoholism and liver damage (author's transl)]. (1981 Jan 23)Neukirchen MMMW Munch Med Wochenschr
29133146Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018 Feb 5)Seiki TGene
3146230Suggestive evidence of genetic linkage between alcoholism and the MNS blood group. (1988 Dec)Hill SYAlcohol Clin Exp Res
28903383Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population. (2017 Aug 15)Ben QOncotarget
22911869Are risk factors associated with outcomes in pancreatic cancer? (2012)Wang DSPLoS One
19758307Determinants of factor VIII plasma levels in carriers of haemophilia A and in control women. (2010 Jan)Ay CHaemophilia
1274569The role of haemolysis in neonatal hyperbilirubinaemia as reflected in carboxyhaemoglobin levels. (1976 May)Necheles TFActa Paediatr Scand
25828346Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. (2015)Hermanns MIInt J Cardiol
24815846Rotation thromboelastometry and the hypercoagulable state in Cushing's syndrome. (2014 Nov)Coelho MCClin Endocrinol (Oxf)
4074023ABO blood group system, age, sex, risk factors and cardiac infarction. (1985 Oct)Platt DArch Gerontol Geriatr
26290123Risk factors for venous thromboembolism in women under combined oral contraceptive. The PILl Genetic RIsk Monitoring (PILGRIM) Study. (2016 Jan)Suchon PThromb Haemost
23187833Demographics and epidemiology of pancreatic cancer. (2012 Nov-Dec)Yeo TPCancer J
712957Myocardial infarction and other vascular diseases in young women. Role of estrogens and other factors. (1978 Dec 1)Jick HJAMA
11281276The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit. (2000 Sep)Gu DFAnn Hum Genet
23305785ABO blood type does not influence the risk of cardiovascular complications and mortality after vascular surgery. (2013 Mar)Bakker EJEur J Vasc Endovasc Surg
28990200Reduced ferritin levels in individuals with non-O blood group: results from the Danish Blood Donor Study. (2017 Dec)Rigas ASTransfusion
15832534Evidence-based prenatal care: Part I. General prenatal care and counseling issues. (2005 Apr 1)Kirkham CAm Fam Physician
26396600Distribution of ABO blood groups in the patients with intracranial aneurysm and association of different risk factors with particular blood type. (2015 Jul-Sep)Bir SCAsian J Neurosurg
1562984Basic evaluation of an immunoradiometric competitive inhibition assay for sialosyl-Tn antigen in sera in women. Assay conditions and normal values. (1992 May 1)Ryuko KCancer
23534732Clinicopathological features of patients with malignant mesothelioma in a multicenter, case-control study: no role for ABO-Rh blood groups. (2013)Utkan GAsian Pac J Cancer Prev
3119387Risk factors for micro- and macroangiopathic complications in type 2 diabetes: lack of association with acetylator phenotype, chlorpropamide alcohol flush and ABO and Rh blood groups. (1987 Jul-Aug)Pontiroli AEDiabete Metab
2996354Risk factors for gestational trophoblastic neoplasia. (1985 Oct 1)Messerli MLAm J Obstet Gynecol
25483106The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer. (2015)Fukumoto KJ Epidemiol
24022193Prognostic value of ABO blood group in southern Chinese patients with established nasopharyngeal carcinoma. (2013 Oct 29)Ouyang PYBr J Cancer
29622982Cardiovascular disease and ABO blood-groups in Africans. Are blood-group A individuals at higher risk of ischemic disease?: A pilot study. (2017 Dec)Ba DMEgypt Heart J
23598597The dormant and the fully competent oocyte: comparing the transcriptome of human oocytes from primordial follicles and in metaphase II. (2013 Sep)Grondahl MLMol Hum Reprod
29072060Risk Factors for Hydatidiform Mole: Is Husband's Job a Major Risk Factor? (2017 Oct 26)Shamshiri Milani HAsian Pac J Cancer Prev