Gene: AMY2B

280
AMY2|AMY3|HXA
amylase, alpha 2B (pancreatic)
protein-coding
1p21.1
Ensembl:ENSG00000240038 MIM:104660 Vega:OTTHUMG00000011024 UniprotKB:P19961
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
4.766e-1 (AD)  6.782e-2 (ND)   (Frontal_Cortex)
1.634e-1 (AD)  1.837e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC31B0.915
GOLGA8A0.901
TTC21A0.897
EXOSC100.889
AGAP60.881
ZNF2510.876
CDRT40.876
WDR190.874
GIT20.87
POGZ0.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.425
OR4F29-0.399
MDFI-0.319
MTRNR2L9-0.319
VAX2-0.318
TMSB15A-0.312
GSC-0.308
CCDC102A-0.307
ZNF114-0.307
KLRC2-0.306

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018701,4-dithio-alpha-D-glucopyranoseSmall MoleculeExperimentalTarget
DB02218N-[4-hydroxymethyl-cyclohexan-6-yl-1,2,3-triol]-4,6-dideoxy-4-aminoglucopyranosideSmall MoleculeExperimentalTarget
DB02379Beta-D-GlucoseSmall Molecule492-61-5ExperimentalTarget
DB027304-Methylthio-Alpha-D-MannoseSmall MoleculeExperimentalTarget
DB03088Pidolic AcidSmall Molecule98-79-3Approved|Experimental|InvestigationalTarget
DB030925-Hydroxymethyl-ChonduritolSmall MoleculeExperimentalTarget
DB03277alpha-maltotrioseSmall MoleculeExperimentalTarget
DB03323MaltoseSmall Molecule69-79-4Experimental|InvestigationalTarget
DB04417P-NitrophenolSmall Molecule100-02-7ExperimentalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of AMY2B mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AMY2B mRNA21632981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AMY2B gene27153756
D001151ArsenicArsenic affects the methylation of AMY2B gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AMY2B mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of AMY2B mRNA21632981
D016572CyclosporineCyclosporine results in decreased expression of AMY2B mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased methylation of AMY2B promoter27989131
C544151jinfukangjinfukang results in decreased expression of AMY2B mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AMY2B mRNA28001369
D010936Plant ExtractsPlant Extracts results in increased expression of AMY2B mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AMY2B mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AMY2B mRNA21570461
D014635Valproic AcidValproic Acid results in decreased expression of AMY2B mRNA26272509
D015032ZincZinc results in increased activity of AMY2B protein17093223
D015034Zinc OxideZinc Oxide results in increased activity of AMY2B protein17093223

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004556alpha-amylase activity-ISS2401405  
GO:0046872metal ion binding-IEA-  
GO:0103025alpha-amylase activity (releasing maltohexaose)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00500Starch and sucrose metabolism
hsa01100Metabolic pathways
hsa04972Pancreatic secretion
hsa04973Carbohydrate digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-189085Digestion of dietary carbohydrateTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24553828Exome sequencing and arrayCGH detection of gene sequence and copy number variation between ILS and ISS mouse strains. (2014 Jun)Dumas LMamm Genome