Gene: SFN

2810
YWHAS
stratifin
protein-coding
1p36.11
Ensembl:ENSG00000175793 MIM:601290 Vega:OTTHUMG00000004093 UniprotKB:P31947
NC_000001.11
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.223e-1 (AD)  6.784e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF12A0.84
CD440.831
GBP20.789
MYBPH0.783
SPOCD10.78
TIMP10.78
PDPN0.769
FABP50.764
TEAD40.761
HAP10.757

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYS1-0.526
ERBB4-0.515
KCNQ4-0.499
LYPD6-0.494
NEUROD6-0.493
KIT-0.487
FRMPD1-0.485
ABCD2-0.477
SLC6A1-0.477
SLC7A4-0.477

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SFN mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SFN mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SFN mRNA"17547211
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of SFN protein"23457121
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of SFN protein"23457121
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SFN mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of SFN mRNA22230336
C109238acylineacyline results in increased expression of SFN mRNA17510436
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of SFN mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SFN protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SFN mRNA21527772|2163298
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SFN mRNA24449571
D001151ArsenicArsenic results in increased expression of SFN mRNA19945496
C006632arsenic trioxideSFN protein results in decreased susceptibility to arsenic trioxide20707922
D001379AzathioprineAzathioprine results in increased expression of SFN mRNA22623647
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SFN mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of SFN mRNA19737606
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SFN mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SFN mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SFN gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SFN mRNA19770486
D004958Estradiol[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with decitabine] results in increased expression of SFN mRNA22534328
D004958Estradiol[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased expression of SFN protein22534328
D004958EstradiolEstradiol results in decreased expression of SFN mRNA23019147|2309414
D004958EstradiolEstradiol results in increased expression of SFN mRNA19167446
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SFN mRNA18556351
C006780bisphenol Abisphenol A results in decreased methylation of SFN promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SFN mRNA25181051
D000069286BortezomibBortezomib results in increased expression of SFN mRNA20977926
D000069286Bortezomib[irinotecan co-treated with Bortezomib] results in decreased expression of SFN protein16373703
C026105butylidenephthalidebutylidenephthalide results in increased expression of SFN protein23770345
C584509C646 compoundC646 compound results in decreased expression of SFN mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SFN mRNA12160620|2559613
C459604candoxincandoxin results in decreased expression of SFN mRNA16309724
D002220CarbamazepineCarbamazepine affects the expression of SFN mRNA25979313
D002699ChlorambucilChlorambucil results in increased expression of SFN mRNA18092340
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of SFN mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SFN mRNA26272509
C100187chloropicrinchloropicrin results in decreased expression of SFN mRNA26352163
D002737ChloropreneChloroprene results in increased expression of SFN mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SFN mRNA20938992
C043561chrysinchrysin results in increased expression of SFN mRNA18331776
C043561chrysinchrysin results in increased expression of SFN protein18331776
C059262cidofovircidofovir results in increased expression of SFN mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of SFN mRNA25596134
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of SFN mRNA15467011
D003300CopperCopper results in increased expression of SFN mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of SFN mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SFN mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of SFN mRNA19167446
D003520CyclophosphamideCyclophosphamide results in increased expression of SFN mRNA21527772
D016572CyclosporineCyclosporine results in increased expression of SFN mRNA20106945|2556210
D003561CytarabineSFN protein results in decreased susceptibility to Cytarabine25189999
D003609DactinomycinDactinomycin results in increased expression of SFN mRNA21527772
C014347decitabinedecitabine results in increased expression of SFN protein22534328|2518999
C014347decitabine[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with decitabine] results in increased expression of SFN mRNA22534328
C014347decitabinedecitabine results in decreased methylation of SFN promoter15979784
C014347decitabinedecitabine results in increased expression of SFN mRNA15979784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SFN mRNA21266533
D003994Bucladesine[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with decitabine] results in increased expression of SFN mRNA22534328
D003994Bucladesine[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased expression of SFN protein22534328
D002945CisplatinCisplatin affects the expression of SFN mRNA25450742
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of SFN mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of SFN protein21924258
D002945CisplatinCisplatin results in increased expression of SFN mRNA21532991|2559613
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of SFN mRNA]27392435
D002945CisplatinSFN protein affects the susceptibility to Cisplatin26894857
D002945CisplatinSFN protein affects the susceptibility to [Fluorouracil co-treated with Cisplatin]15999354
D004008DiclofenacDiclofenac results in increased expression of SFN mRNA17379860
D004052Diethylnitrosamine"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of SFN protein"23457121
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SFN mRNA15171707|1663631
D002117CalcitriolCalcitriol results in increased expression of SFN mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SFN mRNA"21527772
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SFN mRNA17547211
D004317DoxorubicinDoxorubicin results in decreased expression of SFN mRNA24816189
D004317DoxorubicinDoxorubicin results in increased expression of SFN protein24816189
D004317DoxorubicinSFN protein affects the susceptibility to Doxorubicin26894857
D004317DoxorubicinTP53 protein mutant form affects the reaction [Doxorubicin results in decreased expression of SFN mRNA]24816189
D004317DoxorubicinTP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of SFN protein]24816189
C118739entinostatentinostat results in increased expression of SFN mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SFN mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFN mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SFN mRNA23649840
D005047EtoposideEtoposide results in increased expression of SFN mRNA21527772
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of SFN mRNA19167416|2221319
D005472FluorouracilFluorouracil affects the expression of SFN mRNA16584549
D005472FluorouracilFluorouracil results in increased expression of SFN mRNA16557594|1798267
D005472FluorouracilSFN protein affects the susceptibility to [Fluorouracil co-treated with Cisplatin]15999354
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of SFN mRNA]15016801
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of SFN mRNA]17982676
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SFN mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of SFN mRNA23649840
C419708gefitinibgefitinib results in decreased expression of SFN mRNA16685379
C056507gemcitabine[DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]25189999
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]25189999
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased methylation of SFN gene25189999
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN mRNA25189999
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN protein25189999
C056507gemcitabinegemcitabine results in increased methylation of SFN gene25189999
C056507gemcitabineSFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]26894857
C056507gemcitabineSFN protein affects the susceptibility to gemcitabine26894857
C056507gemcitabineSFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]26894857
C056507gemcitabineSFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]26894857
C056507gemcitabineSFN protein promotes the reaction [gemcitabine results in decreased susceptibility to gemcitabine]25189999
C056507gemcitabineSFN protein results in decreased susceptibility to gemcitabine25189999|2689485
C056507gemcitabine[UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]25189999
C056507gemcitabineYAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]26894857
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SFN mRNA22634610
D007052IbuprofenIbuprofen results in increased expression of SFN mRNA25596134
D007069IfosfamideIfosfamide results in increased expression of SFN mRNA25596134
C051890irinotecan[irinotecan co-treated with Bortezomib] results in decreased expression of SFN protein16373703
D007545IsoproterenolIsoproterenol results in decreased expression of SFN mRNA24286936
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of SFN mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of SFN mRNA]27392435
C544151jinfukangjinfukang results in increased expression of SFN mRNA27392435
C410337K 7174K 7174 results in increased expression of SFN mRNA24086573
C006552kaempferolkaempferol results in increased expression of SFN mRNA18331776
C006552kaempferolkaempferol results in increased expression of SFN protein18331776
C008261lead acetatelead acetate results in decreased expression of SFN mRNA20680508
C533894LG 100815LG 100815 results in decreased expression of SFN mRNA16951191
D047311LuteolinLuteolin results in increased expression of SFN mRNA18331776
D047311LuteolinLuteolin results in increased expression of SFN protein18331776
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with decitabine] results in increased expression of SFN mRNA22534328
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased expression of SFN protein22534328
C042720mercuric bromidemercuric bromide results in increased expression of SFN mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
D008687MetforminMetformin results in increased expression of SFN mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SFN mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of SFN mRNA17379860|2167806
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SFN mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SFN protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SFN mRNA21527772|2364984
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SFN protein26558463
D008942MitoxantroneSFN protein affects the susceptibility to Mitoxantrone16217747
D009151Mustard GasMustard Gas results in increased alkylation of SFN protein18342354
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SFN protein"22001959
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SFN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SFN mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of SFN mRNA18978301
D009532NickelNickel results in increased expression of SFN mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of SFN mRNA16100012|1616674
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA"18778698
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA]"18778698
C464660obeticholic acidobeticholic acid results in decreased expression of SFN mRNA27939613
C025589ochratoxin Aochratoxin A results in increased expression of SFN mRNA19237604
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of SFN mRNA"16951191
D010100OxygenOxygen deficiency results in increased expression of SFN mRNA25596134
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SFN mRNA25658374
D010126OzoneOzone results in increased expression of SFN mRNA12763052|1709563
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SFN mRNA26272509
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SFN mRNA18593933
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SFN mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SFN mRNA17426115
D011374ProgesteroneProgesterone results in increased expression of SFN mRNA20631399
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SFN mRNA18556351
D011374ProgesteroneProgesterone results in decreased expression of SFN mRNA16966611
D011374ProgesteroneProgesterone results in increased phosphorylation of SFN protein17303654
D011794QuercetinQuercetin results in increased expression of SFN mRNA18331776|2163298
D011794QuercetinQuercetin results in increased expression of SFN protein14750173|1833177
D012834SilverSilver results in increased expression of SFN mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of SFN mRNA12760830
D012969Sodium FluorideSodium Fluoride results in increased expression of SFN protein27548804
D053260SootSoot results in increased expression of SFN mRNA26551751
C016766sulforafanSFN protein binds to sulforafan21838287
D013629TamoxifenTamoxifen results in increased expression of SFN mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SFN mRNA27913140
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFN mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SFN mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SFN mRNA19770486
C009438tetrandrinetetrandrine results in increased expression of SFN protein26822499
C009495titanium dioxidetitanium dioxide results in increased expression of SFN mRNA23409001|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SFN protein27818348
D014118Toxins, Biological"Toxins, Biological affects the expression of SFN mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of SFN mRNA"17951470
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SFN mRNA24935251|2627250
C001899triptolidetriptolide results in increased expression of SFN protein26990902
D014520UrethaneUrethane results in decreased expression of SFN mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SFN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SFN mRNA23179753|2438349
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SFN mRNA"27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SFN mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11574543  11697890  12383250  15161933  15173315  15657067  
15696159  15778465  15923258  16189514  16672277  16767219  
16799092  16902409  18339811  18647389  19172738  19640509  
20005908  20179209  20206173  20618440  20843328  21625211  
21988832  23572552  23752268  24189400  24658140  25416956  
25852190  26496610  27107014  
GO:0008426protein kinase C inhibitor activity-TAS8515476  
GO:0019901protein kinase binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0042802identical protein binding-IPI15778465  
GO:0045296cadherin binding-HDA25468996  
GO:0051219phosphoprotein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IEA-  
GO:0001836release of cytochrome c from mitochondria-IDA11574543  
GO:0003334keratinocyte development-IEA-  
GO:0006469negative regulation of protein kinase activity-TAS8515476  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007165signal transduction-TAS8515476  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IDA11574543  
GO:0010482regulation of epidermal cell division-ISS-  
GO:0010839negative regulation of keratinocyte proliferation-IEA-  
GO:0030307positive regulation of cell growth-IEA-  
GO:0031424keratinization-IEA-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA11574543  
GO:0045606positive regulation of epidermal cell differentiation-ISS-  
GO:0046827positive regulation of protein export from nucleus-IEA-  
GO:0061024membrane organization-TAS-  
GO:0061436establishment of skin barrier-ISS-  
GO:0071901negative regulation of protein serine/threonine kinase activity-IEA-  
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS8515476  
GO:0005634nucleus-IEA-  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-111447Activation of BAD and translocation to mitochondria TAS
R-HSA-114452Activation of BH3-only proteinsTAS
R-HSA-1445148Translocation of GLUT4 to the plasma membraneTAS
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5625740RHO GTPases activate PKNsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28586068Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract. (2017 Aug)Jiao ZMol Med Rep
21380558Methylation analysis of cancer-related genes in non-neoplastic cells from patients with oral squamous cell carcinoma. (2011 Nov)de Freitas Cordeiro-Silva MMol Biol Rep
29197760Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)Callahan CLEnviron Res
2131813[The evaluation of the measurement of serum fibronectin in pulmonary tuberculosis]. (1990 Apr-Jun)Cioflec DRev Ig Med Muncii Med Soc Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol