Gene info: ID 2811

Gene: GP1BA

GENE ID: 2811

Description: glycoprotein Ib platelet subunit alpha

Gene type: protein-coding

Location: 17p13.2

dbXrefs: Ensembl:ENSG00000185245 MIM:606672 Vega:OTTHUMG00000177946 UniprotKB:P07359

RefSeq: NG_008767.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.420e-1 (AD) 8.025e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DEFB115	0.585
PLA2G4E	0.582
FAM83C	0.58
PKD1L3	0.577
OPN1MW2	0.575
FGF21	0.565
GPX2	0.548
PLA2G2E	0.547
GJA8	0.545
ELMSAN1	0.54

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RERGL	-0.259
NHLRC4	-0.246
ACY3	-0.236
GSDMC	-0.207
FCRL4	-0.195
OR4F5	-0.195
TDGF1	-0.194
HAPLN1	-0.175
OR4F29	-0.171
PIP	-0.169

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05202	Egaptivon pegol	BiotechDrug	934868-74-3	Investigational	Target
DB05391	liposomal prostaglandin E1	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C553100	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]	20523355
C553100	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]	20523355
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]	20523355
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of GP1BA protein]"	20523355
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]	20523355
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of GP1BA protein]"	20523355
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of GP1BA mRNA	24449571
D001241	Aspirin	GP1BA polymorphism affects the susceptibility to Aspirin	17630485
D001241	Aspirin	GP1BA polymorphism results in increased susceptibility to Aspirin	19250145
D001241	Aspirin	GP1BA SNP results in decreased susceptibility to Aspirin	17245331
D001280	Atrazine	Atrazine results in increased expression of GP1BA mRNA	22378314
D001554	Benzene	Benzene results in decreased expression of GP1BA mRNA	19162166
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of GP1BA mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GP1BA mRNA	22300585
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of GP1BA mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of GP1BA mRNA	25181051
D002784	Cholesterol	Cholesterol results in increased expression of GP1BA mRNA	26296894
D003300	Copper	[Copper co-treated with Dietary Sucrose] results in increased expression of GP1BA mRNA	26033743
D003300	Copper	Copper deficiency results in increased expression of GP1BA mRNA	26033743
D019422	Dietary Sucrose	[Copper co-treated with Dietary Sucrose] results in increased expression of GP1BA mRNA	26033743
D004546	Elapid Venoms	Elapid Venoms results in increased cleavage of GP1BA protein	11333182
C544151	jinfukang	jinfukang results in increased expression of GP1BA mRNA	27392435
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GP1BA mRNA"	25554681
C060974	phosphatidylinositol 3,4,5-triphosphate	"[VWF protein binds to GP1BA protein binds to GP9 protein binds to GP5 protein] which results in increased abundance of phosphatidylinositol 3,4,5-triphosphate"	12606772
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GP1BA mRNA	23608068
C432165	pyrazolanthrone	pyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein]	20523355
D012834	Silver	Silver affects the expression of GP1BA mRNA	27131904
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of GP1BA mRNA	26496021
D013755	Tetradecanoylphorbol Acetate	10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]	20523355
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein	20523355
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]	20523355
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]	20523355
C113580	U 0126	U 0126 inhibits the reaction [THPO protein results in increased expression of GP1BA protein]	20523355
D014520	Urethane	Urethane results in increased expression of GP1BA mRNA	28818685
D001335	Vehicle Emissions	Vehicle Emissions results in increased secretion of GP1BA protein alternative form	22542759
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GP1BA gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	1730602 7721887 12183630 12855810 15039442 18674540 18789323 19828450 25666618 29187380
GO:0015057	thrombin-activated receptor activity	-	TAS	12855810

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000902	cell morphogenesis	-	IEA	-
GO:0007155	cell adhesion	-	IBA	21873635
GO:0007155	cell adhesion	-	IDA	9410473
GO:0007166	cell surface receptor signaling pathway	-	TAS	3353370
GO:0007596	blood coagulation	-	IBA	21873635
GO:0007596	blood coagulation	-	IMP	21037087
GO:0007596	blood coagulation	-	TAS	-
GO:0007597	blood coagulation, intrinsic pathway	-	TAS	-
GO:0030168	platelet activation	-	TAS	12855810
GO:0030193	regulation of blood coagulation	-	TAS	12855810
GO:0042730	fibrinolysis	-	IDA	12855810
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	-
GO:0070493	thrombin-activated receptor signaling pathway	-	IEA	-
GO:0070527	platelet aggregation	-	IBA	21873635
GO:0070527	platelet aggregation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	15297306
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	3353370
GO:0009986	cell surface	-	HDA	23382103
GO:0016020	membrane	-	IDA	15297306
GO:0031362	anchored component of external side of plasma membrane	COLOCALIZES_WITH	IBA	21873635
GO:0031362	anchored component of external side of plasma membrane	colocalizes_with	IDA	19443707
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04512	ECM-receptor interaction
hsa04640	Hematopoietic cell lineage

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	TAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-430116	GP1b-IX-V activation signalling	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75892	Platelet Adhesion to exposed collagen	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76009	Platelet Aggregation (Plug Formation)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23252292	[Correlation of coronary heart disease with multiple genes, gene polymorphisms and multiple risk factors in old Chinese Han patients]. (2012 Sep)	Sun YF	Zhongguo Ying Yong Sheng Li Xue Za Zhi
25155498	Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction. (2016 Mar)	Kaur R	Clin Appl Thromb Hemost
22535530	Prothrombotic gene polymorphisms and plasma factors in young North Indian survivors of acute myocardial infarction. (2012 Aug)	Dogra RK	J Thromb Thrombolysis