Gene: GP1BA

2811
BDPLT1|BDPLT3|BSS|CD42B|CD42b-alpha|DBPLT3|GP1B|GPIbA|GPIbalpha|VWDP
glycoprotein Ib platelet subunit alpha
protein-coding
17p13.2
Ensembl:ENSG00000185245 MIM:606672 Vega:OTTHUMG00000177946 UniprotKB:P07359
NG_008767.2
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.420e-1 (AD)  8.025e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEFB1150.585
PLA2G4E0.582
FAM83C0.58
PKD1L30.577
OPN1MW20.575
FGF210.565
GPX20.548
PLA2G2E0.547
GJA80.545
ELMSAN10.54

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RERGL-0.259
NHLRC4-0.246
ACY3-0.236
GSDMC-0.207
FCRL4-0.195
OR4F5-0.195
TDGF1-0.194
HAPLN1-0.175
OR4F29-0.171
PIP-0.169

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05202Egaptivon pegolBiotechDrug934868-74-3InvestigationalTarget
DB05391liposomal prostaglandin E1Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]20523355
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [THPO protein results in increased expression of GP1BA protein]"20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [THPO protein results in increased expression of GP1BA protein]"20523355
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GP1BA mRNA24449571
D001241AspirinGP1BA polymorphism affects the susceptibility to Aspirin17630485
D001241AspirinGP1BA polymorphism results in increased susceptibility to Aspirin19250145
D001241AspirinGP1BA SNP results in decreased susceptibility to Aspirin17245331
D001280AtrazineAtrazine results in increased expression of GP1BA mRNA22378314
D001554BenzeneBenzene results in decreased expression of GP1BA mRNA19162166
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of GP1BA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GP1BA mRNA22300585
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of GP1BA mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GP1BA mRNA25181051
D002784CholesterolCholesterol results in increased expression of GP1BA mRNA26296894
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of GP1BA mRNA26033743
D003300CopperCopper deficiency results in increased expression of GP1BA mRNA26033743
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of GP1BA mRNA26033743
D004546Elapid VenomsElapid Venoms results in increased cleavage of GP1BA protein11333182
C544151jinfukangjinfukang results in increased expression of GP1BA mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GP1BA mRNA"25554681
C060974phosphatidylinositol 3,4,5-triphosphate"[VWF protein binds to GP1BA protein binds to GP9 protein binds to GP5 protein] which results in increased abundance of phosphatidylinositol 3,4,5-triphosphate"12606772
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GP1BA mRNA23608068
C432165pyrazolanthronepyrazolanthrone promotes the reaction [THPO protein results in increased expression of GP1BA protein]20523355
D012834SilverSilver affects the expression of GP1BA mRNA27131904
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of GP1BA mRNA26496021
D013755Tetradecanoylphorbol Acetate10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]20523355
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GP1BA protein20523355
D013755Tetradecanoylphorbol AcetateU 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]20523355
C113580U 0126U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GP1BA protein]20523355
C113580U 0126U 0126 inhibits the reaction [THPO protein results in increased expression of GP1BA protein]20523355
D014520UrethaneUrethane results in increased expression of GP1BA mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in increased secretion of GP1BA protein alternative form22542759
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GP1BA gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI1730602  7721887  12183630  12855810  15039442  18674540  
18789323  19828450  25666618  29187380  
GO:0015057thrombin-activated receptor activity-TAS12855810  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0007155cell adhesion-IDA9410473  
GO:0007166cell surface receptor signaling pathway-TAS3353370  
GO:0007596blood coagulation-IBA21873635  
GO:0007596blood coagulation-IMP21037087  
GO:0007596blood coagulation-TAS-  
GO:0007597blood coagulation, intrinsic pathway-TAS-  
GO:0030168platelet activation-TAS12855810  
GO:0030193regulation of blood coagulation-TAS12855810  
GO:0042730fibrinolysis-IDA12855810  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0070493thrombin-activated receptor signaling pathway-IEA-  
GO:0070527platelet aggregation-IBA21873635  
GO:0070527platelet aggregation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA15297306  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS3353370  
GO:0009986cell surface-HDA23382103  
GO:0016020membrane-IDA15297306  
GO:0031362anchored component of external side of plasma membraneCOLOCALIZES_WITHIBA21873635  
GO:0031362anchored component of external side of plasma membranecolocalizes_withIDA19443707  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-430116GP1b-IX-V activation signallingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75892Platelet Adhesion to exposed collagenTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23252292[Correlation of coronary heart disease with multiple genes, gene polymorphisms and multiple risk factors in old Chinese Han patients]. (2012 Sep)Sun YFZhongguo Ying Yong Sheng Li Xue Za Zhi
25155498Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction. (2016 Mar)Kaur RClin Appl Thromb Hemost
22535530Prothrombotic gene polymorphisms and plasma factors in young North Indian survivors of acute myocardial infarction. (2012 Aug)Dogra RKJ Thromb Thrombolysis