Gene: GP1BB

2812
BDPLT1|BS|CD42C|GPIBB|GPIbbeta
glycoprotein Ib platelet subunit beta
protein-coding
22q11.21
Ensembl:ENSG00000203618 MIM:138720 Vega:OTTHUMG00000150397 UniprotKB:P13224
NG_007974.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of GP1BB mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of GP1BB mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of GP1BB mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GP1BB gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GP1BB mRNA16483693
D001151ArsenicArsenic affects the expression of GP1BB mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of GP1BB mRNA28793237
D001554BenzeneBenzene results in decreased expression of GP1BB mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GP1BB mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of GP1BB mRNA25181051
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of GP1BB mRNA28793237
D002104CadmiumCadmium results in increased expression of GP1BB mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GP1BB mRNA17484886
D002330CarmustineCarmustine results in decreased expression of GP1BB mRNA15980968
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of GP1BB protein23811945
D002945CisplatinCisplatin results in increased expression of GP1BB mRNA19561079
D002945CisplatinCisplatin results in decreased expression of GP1BB mRNA22023808
C004912ethylbenzeneethylbenzene results in decreased expression of GP1BB mRNA20955722
D005472FluorouracilFluorouracil affects the expression of GP1BB mRNA16584549
C069837fullerene C60fullerene C60 results in decreased expression of GP1BB mRNA19167457
C039281furanfuran results in decreased expression of GP1BB mRNA25539665|2619464
D005839GentamicinsGentamicins results in increased expression of GP1BB mRNA22061828
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of GP1BB mRNA17572062
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GP1BB mRNA23086925
D008752Methylene ChlorideMethylene Chloride results in decreased expression of GP1BB mRNA20955722
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GP1BB mRNA"20188158
D008743Methyl ParathionMethyl Parathion results in increased expression of GP1BB mRNA19784758
C031721naphthalenenaphthalene results in increased expression of GP1BB mRNA18978301
C028007nickel monoxidenickel monoxide results in decreased expression of GP1BB mRNA19167457
D011374ProgesteroneProgesterone results in decreased expression of GP1BB mRNA20726854
C030984pyrenepyrene results in increased expression of GP1BB mRNA23656968
C059514resveratrolresveratrol results in increased expression of GP1BB mRNA23419489
D053260SootSoot results in increased expression of GP1BB mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GP1BB mRNA24680724
C009495titanium dioxidetitanium dioxide results in decreased expression of GP1BB mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GP1BB mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GP1BB mRNA20955722
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GP1BB mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of GP1BB mRNA19140230
D014635Valproic AcidValproic Acid results in increased methylation of GP1BB gene29154799
D014639VanadiumVanadium results in decreased expression of GP1BB mRNA19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS3353370  
GO:0005515protein binding-IPI4044584  11943773  18674540  18789323  
GO:0042802identical protein binding-IPI18674540  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007166cell surface receptor signaling pathway-NAS3353370  
GO:0007596blood coagulation-TAS-  
GO:0007597blood coagulation, intrinsic pathway-TAS-  
GO:0030168platelet activation-NAS12871509  
GO:0030168platelet activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS3353370  
KEGG ID KEGG Term
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-430116GP1b-IX-V activation signallingTAS
R-HSA-75892Platelet Adhesion to exposed collagenTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics