Gene: GP2

2813
ZAP75
glycoprotein 2
protein-coding
16p12.3
Ensembl:ENSG00000169347 MIM:602977 Vega:OTTHUMG00000131489 UniprotKB:P55259
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.675e-1 (AD)  2.606e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELA3B0.969
PNLIPRP10.967
CTRB10.96
CELA3A0.959
PLA2G1B0.958
CPB10.954
CPA10.951
CTRB20.95
SPINK10.925
CLPS0.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.211
CTSV-0.19
TM4SF19-0.189
PSG11-0.186
CYP2A6-0.183
FGF23-0.179
FOXN4-0.178
CRLF2-0.175
RNF133-0.174
OR1N1-0.172

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GP2 mRNA"19114083
D000082AcetaminophenAcetaminophen results in increased expression of GP2 mRNA26690555
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GP2 mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of GP2 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GP2 mRNA16483693
D001151ArsenicArsenic affects the methylation of GP2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GP2 mRNA22228805
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of GP2 mRNA26945725
D004958EstradiolEstradiol results in increased expression of GP2 mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of GP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GP2 mRNA18180321
D002737ChloropreneChloroprene results in increased expression of GP2 mRNA23125180
D002994ClofibrateClofibrate results in decreased expression of GP2 mRNA22300585
D003042CocaineCocaine affects the expression of GP2 mRNA20187946
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GP2 mRNA22129741
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GP2 mRNA"19480007
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of GP2 mRNA17183730
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GP2 mRNA22129741
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GP2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GP2 mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GP2 mRNA27935865
C025256nonylphenolnonylphenol results in decreased expression of GP2 mRNA22982499
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GP2 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of GP2 mRNA17426115
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of GP2 mRNA26945725
C016104sodium bichromatesodium bichromate results in increased expression of GP2 mRNA22561333
D053260SootSoot results in decreased expression of GP2 mRNA26551751
D013792ThalidomideThalidomide results in increased expression of GP2 mRNA26217789
C009495titanium dioxidetitanium dioxide results in decreased expression of GP2 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of GP2 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GP2 mRNA20133372
D014520UrethaneUrethane results in decreased expression of GP2 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of GP2 mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24222853Epicardial coronary arteries in khat chewers presenting with myocardial infarction. (2013)Al-Motarreb AInt J Vasc Med
28575117Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. (2017)Miller MAPLoS One