Gene: GP5

2814
CD42d|GPV
glycoprotein V platelet
protein-coding
3q29
Ensembl:ENSG00000178732 MIM:173511 Vega:OTTHUMG00000150345 UniprotKB:P40197
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.163e-1 (AD)  9.701e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1572840chr3:194398854 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13185177chr3:194119885GP56.500e-15Smoking27651444
cg14880079chr3:194120150GP51.400e-9Smoking27651444
cg13185177chr3:194119885GP52.120e-8Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A80.426
TLL10.403
DACH10.401
SEMA3E0.389
ADCY50.384
ZNF8430.38
FILIP10.378
C17orf1070.375
PLBD20.373
ETV10.372

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFN-0.276
MYBPH-0.276
MTRNR2L10-0.265
CD44-0.264
CLCF1-0.262
NUPR1-0.259
GBP2-0.257
MTRNR2L8-0.257
PIRT-0.257
NMI-0.251

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C496492abrineabrine results in increased expression of GP5 mRNA22595364
D020106AcrylamideAcrylamide results in decreased expression of GP5 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GP5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GP5 mRNA24449571
D005419FlavonoidsFlavonoids results in increased expression of GP5 mRNA18035473
C016517indole-3-carbinolindole-3-carbinol affects the expression of GP5 mRNA21396975
D009151Mustard GasMustard Gas results in increased expression of GP5 protein28962529
C025589ochratoxin Aochratoxin A results in increased expression of GP5 mRNA22124623
C025589ochratoxin Aochratoxin A results in increased expression of GP5 mRNA22124623
C060974phosphatidylinositol 3,4,5-triphosphate"[VWF protein binds to GP1BA protein binds to GP9 protein binds to GP5 protein] which results in increased abundance of phosphatidylinositol 3,4,5-triphosphate"12606772
C006253pirinixic acidpirinixic acid results in decreased expression of GP5 mRNA19162173
C009495titanium dioxidetitanium dioxide results in decreased expression of GP5 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of GP5 gene26756918
D014118Toxins, Biological"Toxins, Biological affects the expression of GP5 mRNA"19682533
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GP5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI1730602  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0007597blood coagulation, intrinsic pathway-TAS-  
GO:0030168platelet activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7690959  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04512ECM-receptor interaction
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-430116GP1b-IX-V activation signallingTAS
R-HSA-75892Platelet Adhesion to exposed collagenTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76009Platelet Aggregation (Plug Formation)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16129653Use of fuzzy neural networks in modeling relationships of HPV infection with apoptotic and proliferation markers in potentially malignant oral lesions. (2005 Nov)Campisi GOral Oncol
27254662Prevalence of genital human papillomavirus among rural and urban populations in southern Yunnan province, China. (2016)Baloch ZBraz J Med Biol Res
25147721Detection of human papillomavirus in chronic cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma. (2014 May)Mirzaie-Kashani EJundishapur J Microbiol
23161344Infection with high-risk HPV types among female sex workers in northern Vietnam. (2013 Feb)Hoang HTJ Med Virol
16507827Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. (2006 Mar 1)Castellsague XJ Natl Cancer Inst
27279791Detection of Human Papillomavirus 16-Specific IgG and IgM Antibodies in Patient Sera: A Potential Indicator of Oral Squamous Cell Carcinoma Risk Factor. (2016)Kerishnan JPInt J Med Sci
15288840Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. (2004 Sep)Campisi GOral Oncol
15729691Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: use of fuzzy neural networks. (2005 Jul 10)Lo Muzio LInt J Cancer
15583544HPV DNA in clinically different variants of oral leukoplakia and lichen planus. (2004 Dec)Campisi GOral Surg Oral Med Oral Pathol Oral Radiol Endod
12794200Prospective study on cervical neoplasia: presence of HPV DNA in cytological smears precedes the development of cervical neoplastic lesions. (2003 Jun)Tachezy RSex Transm Infect
18164962High association of human papillomavirus infection with oral cancer: a case-control study. (2008 Feb)Anaya-Saavedra GArch Med Res
24151387No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil. (2013 Oct 21)Antunes LCWorld J Gastroenterol
20695077Human papillomavirus as an independent predictor in oral squamous cell cancer. (2009 Sep)Zhao DInt J Oral Sci
19654578Differences in the risk of cervical cancer and human papillomavirus infection by education level. (2009 Sep 1)Franceschi SBr J Cancer
16476033H3 and H3.3 histone mRNA amounts and ratio in oral squamous cell carcinoma and leukoplakia. (2006 Mar)Piscopo MOral Dis
11574131Using a new HPV detection system in epidemiological research: change of views on cervical dyskaryosis? (2001 Oct)Reesink-Peters NEur J Obstet Gynecol Reprod Biol