Gene: GPLD1

2822
GPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLD
glycosylphosphatidylinositol specific phospholipase D1
protein-coding
6p22.3
Ensembl:ENSG00000112293 MIM:602515 Vega:OTTHUMG00000016104 UniprotKB:P80108
NG_029888.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.809e-1 (AD)  9.210e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN8A0.933
PPM1E0.916
CDKL20.914
PCDHAC20.913
NBEA0.912
KCNH10.909
GDPD10.901
NCR3LG10.899
SMIM170.897
UNC800.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.594
ROM1-0.587
S100A16-0.548
COPZ2-0.53
VAMP5-0.53
GNG5-0.527
MYL3-0.52
BCL7C-0.52
PXDC1-0.519
HEY2-0.519

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of GPLD1 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GPLD1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GPLD1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of GPLD1 mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GPLD1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GPLD1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPLD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPLD1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GPLD1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GPLD1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GPLD1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GPLD1 mRNA22100608|2715375
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GPLD1 mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of GPLD1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GPLD1 mRNA16483693
D001553BenzbromaroneBenzbromarone affects the expression of GPLD1 mRNA19483382
C006780bisphenol Abisphenol A results in decreased expression of GPLD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GPLD1 gene28505145
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of GPLD1 mRNA12082028
C018475butyraldehydebutyraldehyde results in decreased expression of GPLD1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of GPLD1 mRNA24752500
C026690cerous chloridecerous chloride results in increased expression of GPLD1 mRNA23573234
D002922CiguatoxinsCiguatoxins affects the expression of GPLD1 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GPLD1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of GPLD1 mRNA17585979|2381119
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GPLD1 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of GPLD1 mRNA19483382
D003471CuprizoneCuprizone results in decreased expression of GPLD1 mRNA26577399
D004008DiclofenacDiclofenac affects the expression of GPLD1 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GPLD1 mRNA26924002
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of GPLD1 mRNA20110567
D004041Dietary FatsDietary Fats results in decreased expression of GPLD1 mRNA15238619
D004041Dietary FatsDietary Fats results in increased expression of GPLD1 mRNA20110567
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GPLD1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GPLD1 mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of GPLD1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GPLD1 mRNA21592394
D004610Ellagic AcidEllagic Acid results in decreased expression of GPLD1 mRNA12002526
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GPLD1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GPLD1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GPLD1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GPLD1 mRNA12082028
D005001EthionineEthionine affects the expression of GPLD1 mRNA19483382
C082360fipronilfipronil results in decreased expression of GPLD1 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of GPLD1 mRNA24136188
D005632FructoseFructose results in increased expression of GPLD1 protein16219662
C039281furanfuran results in decreased expression of GPLD1 mRNA25539665
C039281furanfuran results in increased methylation of GPLD1 gene22079235
D005897GlafenineGlafenine results in decreased expression of GPLD1 mRNA24136188
D048628KetolidesKetolides analog results in decreased expression of GPLD1 mRNA24967691
C045463leflunomideleflunomide results in decreased expression of GPLD1 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GPLD1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GPLD1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of GPLD1 promoter"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of GPLD1 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GPLD1 mRNA26924002
C051752nefazodonenefazodone results in decreased expression of GPLD1 mRNA24136188
D009532NickelNickel results in decreased expression of GPLD1 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of GPLD1 mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of GPLD1 mRNA19483382
C046012pentanalpentanal results in decreased expression of GPLD1 mRNA26079696
D010634PhenobarbitalPhenobarbital results in increased expression of GPLD1 mRNA12082028
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of GPLD1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of GPLD1 mRNA20059764|2081375
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of GPLD1 mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of GPLD1 mRNA19483382
D059808PolyphenolsPolyphenols results in decreased expression of GPLD1 mRNA16293270
D011441PropylthiouracilPropylthiouracil affects the expression of GPLD1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of GPLD1 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of GPLD1 mRNA12002526
C089032rimonabantrimonabant results in decreased expression of GPLD1 mRNA20110567
D012969Sodium FluorideSodium Fluoride results in increased expression of GPLD1 protein28918527
D012999SomanSoman results in decreased expression of GPLD1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of GPLD1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GPLD1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of GPLD1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPLD1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GPLD1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GPLD1 mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GPLD1 mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of GPLD1 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of GPLD1 mRNA23411599
D014280TriglyceridesGPLD1 protein affects the abundance of Triglycerides16219662
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GPLD1 mRNA29024780
C080163trovafloxacintrovafloxacin results in increased expression of GPLD1 mRNA24136188
C406224valdecoxibvaldecoxib results in decreased expression of GPLD1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPLD1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GPLD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GPLD1 mRNA24383497
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GPLD1 gene25560391
D015032ZincZinc deficiency results in decreased expression of GPLD1 mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in decreased expression of GPLD1 mRNA]16140947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004621glycosylphosphatidylinositol phospholipase D activity-IBA21873635  
GO:0004621glycosylphosphatidylinositol phospholipase D activity-IDA1833386  2760042  15907827  17720976  19135435  
GO:0004621glycosylphosphatidylinositol phospholipase D activity-TAS2017684  
GO:0004630phospholipase D activity-IDA2760042  
GO:0017080sodium channel regulator activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-ISS-  
GO:0002042cell migration involved in sprouting angiogenesis-IMP17720976  
GO:0002062chondrocyte differentiation-ISS-  
GO:0002430complement receptor mediated signaling pathway-IDA15907827  19135435  
GO:0006501C-terminal protein lipidation-TAS-  
GO:0006507GPI anchor release-IBA21873635  
GO:0006507GPI anchor release-IDA2760042  15907827  19135435  
GO:0006507GPI anchor release-IMP17720976  
GO:0008285negative regulation of cell proliferation-IDA19135435  
GO:0008286insulin receptor signaling pathway-IDA18328347  
GO:0009749response to glucose-IDA15907827  
GO:0010595positive regulation of endothelial cell migration-IMP17720976  
GO:0010694positive regulation of alkaline phosphatase activity-ISS-  
GO:0010867positive regulation of triglyceride biosynthetic process-ISS-  
GO:0010897negative regulation of triglyceride catabolic process-ISS-  
GO:0010907positive regulation of glucose metabolic process-ISS-  
GO:0010983positive regulation of high-density lipoprotein particle clearance-ISS-  
GO:0032869cellular response to insulin stimulus-IDA15907827  
GO:0035690cellular response to drug-IDA17761367  
GO:0035701hematopoietic stem cell migration-TAS17368745  
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-ISS-  
GO:0043065positive regulation of apoptotic process-IDA19135435  
GO:0045919positive regulation of cytolysis-IDA15907827  19135435  
GO:0046470phosphatidylcholine metabolic process-ISS-  
GO:0046470phosphatidylcholine metabolic process-TAS2017684  
GO:0051044positive regulation of membrane protein ectodomain proteolysis-IDA17720976  
GO:0051047positive regulation of secretion-ISS-  
GO:0070633transepithelial transport-ISS-  
GO:0071277cellular response to calcium ion-IDA2760042  
GO:0071397cellular response to cholesterol-IMP17761367  
GO:0071401cellular response to triglyceride-IMP17761367  
GO:0071467cellular response to pH-IDA17761367  
GO:0097241hematopoietic stem cell migration to bone marrow-TAS17368745  
GO:1900076regulation of cellular response to insulin stimulus-IDA18328347  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA1833386  2760042  15907827  17720976  17761367  
GO:0005622intracellular-IDA15907827  
GO:0005737cytoplasm-IDA19135435  
GO:0005737cytoplasm-ISS-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0031012extracellular matrix-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA1833386  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27344311MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. (2016 Sep)von Toerne CDiabetologia