Gene: GPM6B

2824
M6B
glycoprotein M6B
protein-coding
Xp22.2
Ensembl:ENSG00000046653 MIM:300051 Vega:OTTHUMG00000021162 UniprotKB:Q13491
NG_011988.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMBIM60.915
SCD50.913
SNX50.91
GLUD10.904
PPP2R5A0.893
ADD30.893
MBOAT20.887
SRI0.884
CPE0.882
EFCAB140.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.753
OR4F5-0.745
FER1L6-0.229
GADL1-0.219
CD163L1-0.207
OR52E4-0.206
DPPA4-0.206
OR51A7-0.205
L1TD1-0.201
OR10A3-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GPM6B mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GPM6B mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GPM6B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GPM6B mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GPM6B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GPM6B gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GPM6B mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of GPM6B mRNA26705709
D016589AstemizoleAstemizole results in increased expression of GPM6B mRNA20221588
D001379AzathioprineAzathioprine results in increased expression of GPM6B mRNA19192274
C547126AZM551248AZM551248 results in decreased expression of GPM6B mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPM6B mRNA18164116
C095105bexarotenebexarotene results in increased expression of GPM6B mRNA17178900
C006780bisphenol Abisphenol A results in increased expression of GPM6B mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of GPM6B mRNA18180321
C018475butyraldehydebutyraldehyde results in increased expression of GPM6B mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of GPM6B mRNA26272509
C023676chloroquine diphosphatechloroquine diphosphate results in increased expression of GPM6B mRNA19192274
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPM6B mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of GPM6B mRNA17382205
D003042CocaineCocaine results in decreased expression of GPM6B mRNA12629581
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of GPM6B mRNA20971185
D016578Crack CocaineCrack Cocaine results in increased expression of GPM6B mRNA12629581
D016572CyclosporineCyclosporine results in decreased expression of GPM6B mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GPM6B mRNA23640034
C014347decitabinedecitabine affects the expression of GPM6B mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GPM6B mRNA28628672
D002945CisplatinCisplatin affects the expression of GPM6B mRNA23300844
D004026DieldrinDieldrin results in decreased expression of GPM6B mRNA28385952
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPM6B mRNA18164116
C118739entinostatentinostat results in increased expression of GPM6B mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
D005047EtoposideGPM6B protein affects the susceptibility to Etoposide16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPM6B mRNA20938992
C039281furanfuran results in increased expression of GPM6B mRNA27387713
C004312glycidolglycidol results in decreased expression of GPM6B mRNA24915197
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of GPM6B mRNA19192274
D017313FenretinideFenretinide results in decreased expression of GPM6B mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GPM6B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of GPM6B mRNA28628672
D007854LeadLead affects the expression of GPM6B mRNA28903495
D007854LeadLead affects the splicing of GPM6B mRNA28903495
C042720mercuric bromidemercuric bromide results in decreased expression of GPM6B mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPM6B mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of GPM6B mRNA19192274
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GPM6B mRNA23649840
D008775MethylprednisoloneMethylprednisolone results in increased expression of GPM6B mRNA19192274
C523799MRK 003GPM6B results in decreased susceptibility to MRK 00319903844
C029938nickel sulfatenickel sulfate results in increased expression of GPM6B mRNA17382205
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of GPM6B mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GPM6B mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of GPM6B mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GPM6B mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of GPM6B mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GPM6B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GPM6B mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of GPM6B mRNA17382205
D011239PrednisolonePrednisolone results in increased expression of GPM6B mRNA19192274
C059514resveratrolresveratrol results in decreased expression of GPM6B mRNA23419489
D012834SilverSilver results in decreased expression of GPM6B mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of GPM6B mRNA21795629
C004648testosterone enanthatetestosterone enanthate affects the expression of GPM6B mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GPM6B mRNA20106945
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GPM6B mRNA25729387
D019772TopotecanTopotecan results in increased expression of GPM6B mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GPM6B mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GPM6B mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of GPM6B mRNA15901671
D014415TunicamycinTunicamycin results in decreased expression of GPM6B mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPM6B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GPM6B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GPM6B gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GPM6B mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of GPM6B mRNA15901671
D014640VancomycinVancomycin results in decreased expression of GPM6B mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GPM6B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0007399nervous system development-NAS8661015  
GO:0015031protein transport-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030501positive regulation of bone mineralization-IMP21638316  
GO:0031175neuron projection development-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IMP21638316  
GO:0051612negative regulation of serotonin uptake-IBA21873635  
GO:0051612negative regulation of serotonin uptake-ISS-  
GO:0051893regulation of focal adhesion assembly-IMP21638316  
GO:0085029extracellular matrix assembly-IMP21638316  
GO:2000009negative regulation of protein localization to cell surface-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0045121membrane raft-IBA21873635  
GO:0045121membrane raft-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29230059Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. (2018 Jan)Sanchez-Roige SNat Neurosci