Gene: IFNL1

282618
IL-29|IL29
interferon lambda 1
protein-coding
19q13.2
Ensembl:ENSG00000182393 MIM:607403 Vega:OTTHUMG00000182807 UniprotKB:Q8IU54
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.252e-1 (AD)  5.715e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs30461chr19:39298475 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDO10.856
KRTAP20-10.855
RUFY40.848
CYP19A10.838
ZBP10.826
CCL70.824
CCL80.813
IL270.802
LGALS140.8
SIGLEC120.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1E2-0.251
YBEY-0.247
SNX22-0.243
ARSE-0.224
POU3F4-0.221
AQP6-0.209
OLIG1-0.202
GNG7-0.202
GDF11-0.2
BCHE-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D019833GenisteinGenistein results in increased expression of IFNL1 mRNA20884965
D014635Valproic AcidValproic Acid results in increased methylation of IFNL1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-IDA12483210  
GO:0005125cytokine activity-IEA-  
GO:0032003interleukin-28 receptor binding-IPI12469119  
GO ID GO Term Qualifier Evidence PubMed
GO:0002829negative regulation of type 2 immune response-IDA19346497  
GO:0007259JAK-STAT cascade-IEA-  
GO:0008285negative regulation of cell proliferation-IDA15166220  15899585  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032696negative regulation of interleukin-13 production-IDA19346497  
GO:0032714negative regulation of interleukin-5 production-IDA19346497  
GO:0032729positive regulation of interferon-gamma production-IDA19346497  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA15166220  
GO:0043381negative regulation of memory T cell differentiation-IDA19346497  
GO:0045087innate immune response-IBA21873635  
GO:0045345positive regulation of MHC class I biosynthetic process-IDA12483210  
GO:0045581negative regulation of T cell differentiation-IDA19346497  
GO:0045892negative regulation of transcription, DNA-templated-IDA19346497  
GO:0045893positive regulation of transcription, DNA-templated-IDA12483210  
GO:0046427positive regulation of JAK-STAT cascade-IDA12483210  
GO:0050778positive regulation of immune response-TAS16014923  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IDA12469119  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA12483210  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005622intracellular-IEA-  
GO:0032002interleukin-28 receptor complex-IDA12469119  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS
R-HSA-8854691Interleukin-20 family signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal