Gene: GPR4

2828
-
G protein-coupled receptor 4
protein-coding
19q13.32
Ensembl:ENSG00000177464 MIM:600551 Vega:OTTHUMG00000182126 UniprotKB:P46093
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.466e-1 (AD)  2.793e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITPRIP0.898
YBX30.885
SOCS30.875
TNFRSF10D0.867
IL4R0.862
NFKB20.86
CDK20.857
ACSL50.857
CDKN1A0.853
LRRC320.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.607
MARCH4-0.587
SLC7A4-0.574
VWC2-0.572
HAPLN1-0.567
PPEF1-0.567
NEUROD6-0.562
GAD2-0.554
DLX1-0.554
CASC15-0.553

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of GPR4 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of GPR4 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of GPR4 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GPR4 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GPR4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GPR4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPR4 mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GPR4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPR4 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of GPR4 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GPR4 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of GPR4 mRNA26079696
D002104CadmiumCadmium results in decreased expression of GPR4 mRNA24376830
D002211CapsaicinCapsaicin results in decreased expression of GPR4 mRNA19602228
D002351CarrageenanCarrageenan results in increased expression of GPR4 mRNA19602228
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GPR4 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of GPR4 mRNA19320972
D003471CuprizoneCuprizone results in increased expression of GPR4 mRNA26577399
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of GPR4 mRNA"27840820
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of GPR4 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of GPR4 mRNA19564919
D008727MethotrexateMethotrexate results in decreased expression of GPR4 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GPR4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPR4 mRNA"25554681
D009532NickelNickel results in increased expression of GPR4 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of GPR4 mRNA22714537
D010634PhenobarbitalPhenobarbital affects the expression of GPR4 mRNA19136022
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of GPR4 mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of GPR4 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of GPR4 mRNA17950772
C012526quercitrinquercitrin results in increased expression of GPR4 mRNA25193878
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of GPR4 mRNA19564919
D012834SilverSilver analog results in increased expression of GPR4 mRNA22727896
D012835Silver NitrateSilver Nitrate results in increased expression of GPR4 mRNA22727896
D012999SomanSoman results in increased expression of GPR4 mRNA19281266
D014635Valproic AcidValproic Acid affects the expression of GPR4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of GPR4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010447response to acidic pH-IEA-  
GO:0016525negative regulation of angiogenesis-IEA-  
GO:0035025positive regulation of Rho protein signal transduction-IBA21873635  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IBA21873635  
GO:0060055angiogenesis involved in wound healing-IEA-  
GO:0072144glomerular mesangial cell development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS8595909  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum