Gene: RBM20

282996
-
RNA binding motif protein 20
protein-coding
10q25.2
Ensembl:ENSG00000203867 MIM:613171 Vega:OTTHUMG00000019043 UniprotKB:Q5T481
NG_021177.1
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.698e-1 (AD)  1.812e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7082195chr10:110667691 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15880704chr10:112546110RBM203.040e-8Maternal smoking in pregnancy27040690
cg15880704chr10:112546110RBM205.730e-9Maternal smoking in pregnancy27040690
cg24495528chr10:112402748RBM205.000e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKH0.751
TLL10.685
DACH10.676
DNAH60.668
RASGRP10.667
FOXP20.663
SMURF10.656
FILIP10.651
GCNT10.649
OCA20.646

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHEX-0.387
BBOX1-0.381
KCNJ16-0.374
ASB4-0.371
DIAPH3-0.359
DDIT4L-0.344
MYL3-0.34
TNFRSF11B-0.336
GHRHR-0.335
S100A1-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RBM20 mRNA"28903501
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of RBM20 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBM20 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBM20 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBM20 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBM20 mRNA"27188386
D001152ArsenicalsArsenicals results in decreased expression of RBM20 mRNA28625800
C006780bisphenol Abisphenol A results in decreased expression of RBM20 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RBM20 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of RBM20 mRNA26079696
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RBM20 mRNA23914054
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of RBM20 mRNA28962523
D004317DoxorubicinDoxorubicin affects the methylation of RBM20 gene28962528
D004317DoxorubicinDoxorubicin results in increased expression of RBM20 mRNA28962528
C118739entinostatentinostat results in increased expression of RBM20 mRNA27188386
D017313FenretinideFenretinide results in increased expression of RBM20 mRNA28973697
C042720mercuric bromidemercuric bromide results in increased expression of RBM20 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBM20 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of RBM20 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RBM20 mRNA28001369
D009532NickelNickel results in decreased expression of RBM20 mRNA24768652|2558310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBM20 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RBM20 mRNA26272509
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of RBM20 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of RBM20 mRNA24780913
C009250sevofluranesevoflurane results in decreased expression of RBM20 mRNA26206149
D013629TamoxifenTamoxifen results in increased expression of RBM20 mRNA25123088
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RBM20 mRNA20133372
C024746tobacco tartobacco tar results in decreased expression of RBM20 mRNA19559774
D014212TretinoinTretinoin results in increased expression of RBM20 mRNA21934132|2372400
C057693troglitazonetroglitazone results in decreased expression of RBM20 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of RBM20 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RBM20 mRNA23179753|2438349
C111237vorinostatvorinostat results in increased expression of RBM20 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-ISS-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006397mRNA processing-IEA-  
GO:0007507heart development-IMP22466703  
GO:0008380RNA splicing-IEA-  
GO:0033120positive regulation of RNA splicing-IMP22466703  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal