Gene: GPR6

2830
-
G protein-coupled receptor 6
protein-coding
6q21
Ensembl:ENSG00000146360 MIM:600553 Vega:OTTHUMG00000015354 UniprotKB:P46095
NC_000006.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.152e-1 (AD)  3.704e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01261007chr6:110300233GPR6Promoter1.691e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ISM20.758
DGAT20.718
DCLK30.717
RGS140.712
DRD10.711
PDYN0.685
ARPP210.685
SLC9A50.684
KCNA40.682
ASPHD20.68

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.416
MBNL3-0.415
FZD10-0.413
KLRB1-0.399
ALDH1A1-0.392
RAI14-0.374
MYL3-0.37
KLRF1-0.37
NEK7-0.369
LRRCC1-0.364

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GPR6 gene28458013
C006780bisphenol Abisphenol A results in decreased expression of GPR6 mRNA25181051
C099555CD 437CD 437 results in decreased expression of GPR6 mRNA12958071
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GPR6 gene20938992
D013759DronabinolDronabinol results in increased expression of GPR6 mRNA21955143
D000431EthanolEthanol results in decreased expression of GPR6 mRNA21955143
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GPR6 gene20938992
C004312glycidolglycidol results in decreased expression of GPR6 mRNA24915197
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GPR6 gene20938992
D009020MorphineMorphine results in decreased expression of GPR6 mRNA21955143
D009538NicotineNicotine results in increased expression of GPR6 mRNA21955143
D010269ParaquatParaquat results in increased expression of GPR6 mRNA17077588
D011441PropylthiouracilPropylthiouracil results in increased expression of GPR6 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of GPR6 mRNA27029645
D012999SomanSoman results in decreased expression of GPR6 mRNA19281266
D015032ZincZinc deficiency results in decreased expression of GPR6 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS7832990  
GO:0038036sphingosine-1-phosphate receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003376sphingosine-1-phosphate signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS7832990  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS7832990  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22671426Role of adrenal glucocorticoid signaling in prefrontal cortex gene expression and acute behavioral responses to ethanol. (2013 Jan)Costin BNAlcohol Clin Exp Res