Gene: OR4C12

283093
OR11-259
olfactory receptor family 4 subfamily C member 12
protein-coding
11p11.12
Ensembl:ENSG00000221954 Vega:OTTHUMG00000166687 UniprotKB:Q96R67
NG_053127.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.283e-1 (AD)  2.878e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDY2A1
OR5F11
TSPY31
OR5M11
OR5T21
KRTAP6-21
KRTAP27-11
OR5W21
MAGEB51
OR8K31

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUT9-0.29
SLC1A4-0.284
TMEM221-0.281
ADCY2-0.28
HHATL-0.275
PCDH9-0.272
CORO2B-0.269
PLA2G6-0.267
TM7SF2-0.266
C16orf95-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OR4C12 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of OR4C12 mRNA25181051
D014635Valproic AcidValproic Acid results in decreased methylation of OR4C12 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0004984olfactory receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0050911detection of chemical stimulus involved in sensory perception of smell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-381753Olfactory Signaling PathwayTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23287867Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors. (2013 Feb 21)Cohen KSBlood