Gene: CDH20

28316
CDH7L3|Cdh7
cadherin 20
protein-coding
18q21.33
Ensembl:ENSG00000101542 MIM:605807 Vega:OTTHUMG00000132768 UniprotKB:Q9HBT6
NC_000018.10
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.406e-1 (AD)  5.093e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs673401chr18:61540199 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12607636chr18:61341069 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP40.875
HEPACAM0.871
NEO10.862
GJA10.861
GPRC5B0.861
METTL7A0.858
PHLPP10.852
NTRK20.844
ACSS10.843
PLXNB10.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.435
FER1L6-0.423
GADL1-0.417
L1TD1-0.409
GALR1-0.404
OR4F29-0.401
SCARA5-0.4
GSDMA-0.4
CITED1-0.393
CTHRC1-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of CDH20 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDH20 gene27153756
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of CDH20 mRNA"25757056
C006780bisphenol Abisphenol A results in decreased expression of CDH20 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CDH20 promoter22457795
D003300CopperCopper deficiency results in increased expression of CDH20 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CDH20 mRNA26033743
C012589trichostatin Atrichostatin A results in decreased expression of CDH20 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of CDH20 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CDH20 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016342catenin complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal