Gene: P4HA3

283208
-
prolyl 4-hydroxylase subunit alpha 3
protein-coding
11q13.4
Ensembl:ENSG00000149380 MIM:608987 Vega:OTTHUMG00000165254 UniprotKB:Q7Z4N8
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.133e-2 (AD)  5.346e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03528246chr11:73995105P4HA32.770e-8Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPCN20.453
PLEKHH20.436
PILRB0.419
KIF26A0.412
THBS30.411
DNMT3A0.41
SNED10.408
CCDC1420.407
ZNF7830.403
JAG20.402

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYNLRB2-0.203
OR4F29-0.189
OR4F5-0.186
USP17L8-0.177
MDS2-0.173
SLC15A5-0.169
RAB41-0.166
BBOX1-0.16
FXYD3-0.159
HIST2H4B-0.157

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of P4HA3 mRNA"27291303
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of P4HA3 mRNA"23196670
C547126AZM551248AZM551248 results in increased expression of P4HA3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of P4HA3 mRNA22178795
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of P4HA3 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of P4HA3 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of P4HA3 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of P4HA3 mRNA20147733
D003976DiazinonDiazinon results in increased expression of P4HA3 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of P4HA3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of P4HA3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of P4HA3 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of P4HA3 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of P4HA3 mRNA20920545
D002117CalcitriolCalcitriol results in decreased expression of P4HA3 mRNA26485663
D005557FormaldehydeFormaldehyde results in increased expression of P4HA3 mRNA28937961
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of P4HA3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of P4HA3 mRNA27392435
C059539midostaurinmidostaurin results in increased expression of P4HA3 mRNA20980353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of P4HA3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of P4HA3 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of P4HA3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of P4HA3 mRNA25729387
D010936Plant ExtractsPlant Extracts results in decreased expression of P4HA3 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of P4HA3 mRNA22714537
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of P4HA3 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of P4HA3 mRNA24612858
D012999SomanSoman results in increased expression of P4HA3 mRNA19281266
D053260SootSoot results in increased expression of P4HA3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of P4HA3 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of P4HA3 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of P4HA3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of P4HA3 mRNA25729387
C011559tributyltintributyltin results in increased expression of P4HA3 mRNA21683754

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004656procollagen-proline 4-dioxygenase activityCONTRIBUTES_TOIBA21873635  
GO:0004656procollagen-proline 4-dioxygenase activity-IEA-  
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IPI25416956  26871637  
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen-IEA-  
GO:0031418L-ascorbic acid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline-IBA21873635  
GO:0019511peptidyl-proline hydroxylation-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28264723Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. (2017 Mar 7)Lin XBMC Med