Gene: PGM2L1

283209
BM32A|PMMLP
phosphoglucomutase 2 like 1
protein-coding
11q13.4
Ensembl:ENSG00000165434 MIM:611610 Vega:OTTHUMG00000168132 UniprotKB:Q6PCE3
NC_000011.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.346e-2 (AD)  6.077e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs658126chr11:74388847 (GRCh38.p7)T>A / T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GDA0.979
PAK30.978
RAB3C0.977
GPR1580.97
FAXC0.969
DYNC1I10.968
NEGR10.967
NRXN30.966
NELL20.966
CADPS0.966

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.586
RNF135-0.583
CHST14-0.565
REST-0.557
HEY2-0.556
YES1-0.552
SYDE1-0.549
RAB13-0.54
ASB4-0.54
RAI14-0.536

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of PGM2L1 mRNA"19095052
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PGM2L1 mRNA"19167446
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of PGM2L1 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PGM2L1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PGM2L1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of PGM2L1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PGM2L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PGM2L1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PGM2L1 mRNA22230336|2649742
D001280AtrazineAtrazine results in decreased expression of PGM2L1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PGM2L1 mRNA22178795
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PGM2L1 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PGM2L1 mRNA"20018196
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of PGM2L1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PGM2L1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of PGM2L1 mRNA24758408
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PGM2L1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of PGM2L1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PGM2L1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PGM2L1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of PGM2L1 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of PGM2L1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of PGM2L1 protein28903499
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PGM2L1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PGM2L1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of PGM2L1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of PGM2L1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PGM2L1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of PGM2L1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of PGM2L1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of PGM2L1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PGM2L1 mRNA25562108|2798913
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PGM2L1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PGM2L1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PGM2L1 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PGM2L1 mRNA21527772
D004237DiuronDiuron results in decreased expression of PGM2L1 mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of PGM2L1 mRNA"23811387
C540355fenamidonefenamidone results in decreased expression of PGM2L1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PGM2L1 mRNA20938992
C039281furanfuran results in increased expression of PGM2L1 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of PGM2L1 mRNA22061828
C071834glycidamideglycidamide results in decreased expression of PGM2L1 mRNA17822822
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PGM2L1 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of PGM2L1 mRNA18927307
D007545IsoproterenolIsoproterenol results in increased expression of PGM2L1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PGM2L1 mRNA27392435
D007854LeadLead affects the expression of PGM2L1 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PGM2L1 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PGM2L1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PGM2L1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PGM2L1 mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PGM2L1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PGM2L1 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PGM2L1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PGM2L1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PGM2L1 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of PGM2L1 mRNA23811387
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PGM2L1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PGM2L1 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of PGM2L1 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of PGM2L1 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PGM2L1 mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of PGM2L1 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PGM2L1 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PGM2L1 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of PGM2L1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PGM2L1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of PGM2L1 mRNA19167446
C009277sodium arsenatesodium arsenate results in increased expression of PGM2L1 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PGM2L1 mRNA21641980
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of PGM2L1 mRNA26496021
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PGM2L1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PGM2L1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PGM2L1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of PGM2L1 mRNA23228038
D014212TretinoinTretinoin results in increased expression of PGM2L1 mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PGM2L1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of PGM2L1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of PGM2L1 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of PGM2L1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PGM2L1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PGM2L1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PGM2L1 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004614phosphoglucomutase activity-EXP1840235  
GO:0046872metal ion binding-IEA-  
GO:0047933glucose-1,6-bisphosphate synthase activity-IBA21873635  
GO:0047933glucose-1,6-bisphosphate synthase activity-IDA17804405  
GO:0047933glucose-1,6-bisphosphate synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005978glycogen biosynthetic process-TAS-  
GO:0005980glycogen catabolic process-TAS-  
GO:0019388galactose catabolic process-TAS-  
GO:0061621canonical glycolysis-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00500Starch and sucrose metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-3322077Glycogen synthesisTAS
R-HSA-70171GlycolysisTAS
R-HSA-70221Glycogen breakdown (glycogenolysis)TAS
R-HSA-70326Glucose metabolismTAS
R-HSA-70370Galactose catabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8982491Glycogen metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19603079Influence of smoking on colonic gene expression profile in Crohn's disease. (2009 Jul 15)Nielsen OHPLoS One