Gene: IGSF22

283284
IGFN2
immunoglobulin superfamily member 22
protein-coding
11p15.1
Ensembl:ENSG00000179057 Vega:OTTHUMG00000160502 UniprotKB:Q8N9C0
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.896e-1 (AD)  7.354e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1867877chr11:18705901 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAMTS190.77
LOXHD10.766
LAMB30.761
DCSTAMP0.729
IGSF9B0.707
PASK0.702
GPR680.699
LAT0.674
OR1L30.674
PDYN0.671

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.351
CCDC121-0.34
HMGN5-0.334
ANTXR1-0.329
NXNL1-0.328
ASB4-0.328
NXT2-0.327
PARD3B-0.321
DIAPH3-0.321
MBNL3-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of IGSF22 mRNA22230336
C029892cupric chloridecupric chloride results in decreased expression of IGSF22 mRNA24650576
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of IGSF22 mRNA"23811387
D007854LeadLead affects the expression of IGSF22 mRNA28903495
D009285NaphthoquinonesNaphthoquinones results in increased expression of IGSF22 mRNA23811387
C005556propionaldehydepropionaldehyde results in decreased expression of IGSF22 mRNA26079696

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008307structural constituent of muscle-IBA21873635  
GO:0051015actin filament binding-IBA21873635  
GO:0051371muscle alpha-actinin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006941striated muscle contraction-IBA21873635  
GO:0007015actin filament organization-IBA21873635  
GO:0030240skeletal muscle thin filament assembly-IBA21873635  
GO:0030241skeletal muscle myosin thick filament assembly-IBA21873635  
GO:0045214sarcomere organization-IBA21873635  
GO:0048739cardiac muscle fiber development-IBA21873635  
GO:0055003cardiac myofibril assembly-IBA21873635  
GO:0055008cardiac muscle tissue morphogenesis-IBA21873635  
GO:0071688striated muscle myosin thick filament assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005859muscle myosin complex-IBA21873635  
GO:0005865striated muscle thin filament-IBA21873635  
GO:0030018Z disc-IBA21873635  
GO:0031430M band-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal