Gene: CXCR3

2833
CD182|CD183|CKR-L2|CMKAR3|GPR9|IP10-R|Mig-R|MigR
C-X-C motif chemokine receptor 3
protein-coding
Xq13.1
Ensembl:ENSG00000186810 MIM:300574 Vega:OTTHUMG00000033326 UniprotKB:P49682
NG_029076.1
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR870.747
POU5F20.698
OR56A40.694
MTRNR2L50.691
IFNK0.687
TAS2R130.684
MROH90.676
TMEM2470.673
OR9Q20.671
MEOX10.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACRV1-0.346
HDDC3-0.327
SPAG8-0.307
MAGEE2-0.307
MCF2-0.303
SMKR1-0.295
CNGA4-0.293
HENMT1-0.289
RHEBL1-0.288
LINC00652-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CXCR3 mRNA"18281256
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CXCR3 mRNA"20816883
D000082AcetaminophenAcetaminophen results in increased expression of CXCR3 protein11739529
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXCR3 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of CXCR3 mRNA16715494
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCR3 mRNA24449571
D001151ArsenicArsenic affects the expression of CXCR3 protein24675094
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXCR3 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of CXCR3 mRNA26595511
C006780bisphenol Abisphenol A results in decreased expression of CXCR3 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of CXCR3 mRNA19818335
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CXCR3 mRNA20360939
D002118Calcium[CXCL10 protein binds to and results in increased activity of CXCR3 protein] which results in increased uptake of Calcium25833952
D002118Calcium[CXCL9 protein binds to and results in increased activity of CXCR3 protein] which results in increased abundance of Calcium12517959
D002118Calcium[[CXCL9 protein binds to and results in increased activity of CXCR3 protein] which results in increased abundance of Calcium] which results in increased expression of EGR1 mRNA12517959
D002118Calcium[CXCL9 protein binds to and results in increased activity of CXCR3 protein] which results in increased uptake of Calcium25833952
D002118CalciumCXCR3 protein affects the abundance of Calcium12055238
C000488cladosporincladosporin results in increased expression of CXCR3 mRNA19818335
C018021cobaltous chloridecobaltous chloride results in decreased expression of CXCR3 mRNA24386269
C038459curdlancurdlan affects the expression of CXCR3 mRNA19904525
D017373Cyproterone Acetate[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CXCR3 protein10770211
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CXCR3 mRNA20426967
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CXCR3 mRNA20360939
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CXCR3 protein10770211
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CXCR3 mRNA23649840
C026098etiracetametiracetam results in increased expression of CXCR3 mRNA20345932
D005557FormaldehydeFormaldehyde results in decreased expression of CXCR3 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of CXCR3 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of CXCR3 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CXCR3 mRNA26752646
D007657Ketone BodiesKetone Bodies results in decreased expression of CXCR3 mRNA16807920
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CXCR3 mRNA12834626
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CXCR3 protein12834626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CXCR3 mRNA23649840
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CXCR3 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CXCR3 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CXCR3 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CXCR3 mRNA"25554681
C490266neoechinulin Aneoechinulin A results in increased expression of CXCR3 mRNA19818335
D009532NickelNickel results in increased expression of CXCR3 mRNA24768652|2558310
D009538NicotineNicotine results in increased expression of CXCR3 mRNA20457658
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of CXCR3 mRNA22561872
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CXCR3 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CXCR3 mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of CXCR3 mRNA23638009
C539933pevonedistatpevonedistat affects the expression of CXCR3 mRNA24634471
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of CXCR3 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of CXCR3 mRNA23557933
D017382Reactive Oxygen Species[CXCR3 protein results in increased expression of EGR1] which results in increased abundance of Reactive Oxygen Species12517959
C059514resveratrolresveratrol results in decreased expression of CXCR3 protein21807089
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of CXCR3 mRNA"21148743
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of CXCR3 protein"21148743|2135743
D053260SootSoot results in decreased expression of CXCR3 mRNA26551751
D013241SterigmatocystinSterigmatocystin results in increased expression of CXCR3 mRNA19818335
C119369TAK 779TAK 779 results in decreased expression of CXCR3 protein21515370
D013654TaurineTaurine results in decreased expression of CXCR3 mRNA16579726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCR3 mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCR3 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of CXCR3 mRNA23557971
C402696TMC 120ATMC 120A results in decreased expression of CXCR3 mRNA19818335
C402696TMC 120ATMC 120A results in increased expression of CXCR3 mRNA19818335
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CXCR3 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CXCR3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CXCR3 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of CXCR3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004950chemokine receptor activity-TAS9064356  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016494C-X-C chemokine receptor activity-IEA-  
GO:0019956chemokine binding-IBA21873635  
GO:0019956chemokine binding-IPI11554781  
GO:0019957C-C chemokine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0002685regulation of leukocyte migration-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006935chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS10903763  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IBA21873635  
GO:0007155cell adhesion-TAS10942362  
GO:0007166cell surface receptor signaling pathway-IDA11554781  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0010818T cell chemotaxis-IEA-  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0019722calcium-mediated signaling-IEA-  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS10903743  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9064356  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29515587T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder. (2018)Patas KFront Immunol
26667180Dysregulation of CD4(+) T Cell Subsets in Intracranial Aneurysm. (2016 Feb)Zhang HFDNA Cell Biol
24997814Differential expression of the inflammation-associated chemokines/cytokines in mouse lung after exposure to cigarette smoke and smoking cessation. (2014 Jun)Li JRZhongguo Yi Xue Ke Xue Yuan Xue Bao
15526056An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. (2004 Oct)Grumelli SPLoS Med
20208554Chemokine receptor CXCR3 is important for lung tissue damage and airway remodeling induced by short-term exposure to cigarette smoking in mice. (2010 Apr)Nie LActa Pharmacol Sin
22494799Chemokine receptor CXCR3 is involved in the acute pancreatitis-associated lung injury. (2012 Jul)Shen JBiomed Pharmacother
19229703Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. (2009 Feb)Brozyna SCOPD
18727632CD8 chemokine receptors in chronic obstructive pulmonary disease. (2008 Oct)Smyth LJClin Exp Immunol
24318111HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3. (2014 Feb 15)Green LAAm J Physiol Lung Cell Mol Physiol
20079227[The changes and significance of interleukin-16 and CXC chemokine receptor 3 expression in pulmonary artery of smokers with chronic obstructive pulmonary disease]. (2009 Oct)Wan PZhonghua Nei Ke Za Zhi
12016104Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. (2002 May 15)Saetta MAm J Respir Crit Care Med