Gene: PRLHR

2834
GPR10|GR3|PrRPR
prolactin releasing hormone receptor
protein-coding
10q26.11
Ensembl:ENSG00000119973 MIM:600895 Vega:OTTHUMG00000019136 UniprotKB:P49683
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.951e-1 (AD)  2.078e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN10.811
SLC32A10.805
BTBD110.804
DLX10.804
ZNF385D0.802
IGF10.799
VWC20.796
SLC10A40.795
KIT0.792
PTHLH0.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDA-0.535
GPR4-0.526
ROM1-0.517
S100A8-0.514
IL4R-0.512
HEBP2-0.511
S100A9-0.508
IFITM2-0.508
OSMR-0.504
OTOS-0.5

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRLHR mRNA"19114083
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of PRLHR mRNA"23829299
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRLHR mRNA16483693
C015001arsenitearsenite results in increased methylation of PRLHR promoter23974009
C095105bexarotenebexarotene results in increased expression of PRLHR mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of PRLHR mRNA25181051
C025256nonylphenolnonylphenol results in increased expression of PRLHR mRNA15620428
D010936Plant ExtractsPlant Extracts results in decreased expression of PRLHR mRNA23557933
C057693troglitazonetroglitazone results in decreased expression of PRLHR mRNA21515302
D014635Valproic AcidValproic Acid results in increased methylation of PRLHR gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS8666380  
GO:0004983neuropeptide Y receptor activity-IEA-  
GO:0005515protein binding-IPI11641419  
GO:0008188neuropeptide receptor activity-TAS9607765  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS8666380  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0007565female pregnancy-TAS9607765  
GO:0042445hormone metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8666380  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814982Cord blood DNA methylation and adiposity measures in early and mid-childhood. (2017)Kresovich JKClin Epigenetics