Gene: HECTD4

283450
C12ord51|C12orf51|HEEL|POTAGE
HECT domain E3 ubiquitin protein ligase 4
protein-coding
12q24.13
Ensembl:ENSG00000173064 Vega:OTTHUMG00000150719 UniprotKB:Q9Y4D8
NC_000012.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.054e-2 (AD)  2.231e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11066280chr12:112379979 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2074356chr12:112207597 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HERC10.96
LMTK20.958
RNF1230.957
PI4KA0.954
RALGPS10.953
HERC20.95
CELSR20.949
TLN20.948
DOCK30.945
ARHGEF110.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.486
MYL3-0.479
RAB13-0.469
OR4F5-0.459
TFPI2-0.459
HEY2-0.455
GNG11-0.444
CSAG1-0.444
RNF135-0.436
ZNF114-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HECTD4 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HECTD4 mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HECTD4 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HECTD4 mRNA20106945|2163298
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HECTD4 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HECTD4 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of HECTD4 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HECTD4 mRNA28628672
C018021cobaltous chloridecobaltous chloride results in decreased expression of HECTD4 mRNA24386269
D003703DemecolcineDemecolcine results in increased expression of HECTD4 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HECTD4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HECTD4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HECTD4 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of HECTD4 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of HECTD4 mRNA28302478
D000431EthanolEthanol results in decreased expression of HECTD4 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HECTD4 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of HECTD4 mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HECTD4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HECTD4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HECTD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HECTD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HECTD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HECTD4 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HECTD4 mRNA24796395
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HECTD4 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HECTD4 mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of HECTD4 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HECTD4 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of HECTD4 mRNA23557933
D011794QuercetinQuercetin results in increased expression of HECTD4 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HECTD4 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HECTD4 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HECTD4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HECTD4 mRNA25729387
D014212TretinoinTretinoin results in increased expression of HECTD4 mRNA21934132
C012589trichostatin Atrichostatin A affects the expression of HECTD4 mRNA28542535
D014520UrethaneUrethane results in increased expression of HECTD4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of HECTD4 mRNA23179753
D014750VincristineVincristine results in increased expression of HECTD4 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006006glucose metabolic process-IMP23575436  
GO:0016567protein ubiquitination-IEA-  
GO:0042593glucose homeostasis-IMP23575436  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal