Gene: GPR12

2835
GPCR12|GPCR21|PPP1R84
G protein-coupled receptor 12
protein-coding
13q12.13
Ensembl:ENSG00000132975 MIM:600752 Vega:OTTHUMG00000016620 UniprotKB:P47775
NC_000013.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.393e-2 (AD)  1.093e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2479505chr13:26756816 (GRCh38.p7)T>A / T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNKSR20.95
CLVS20.941
RBFOX10.939
GABRB30.935
GDA0.935
MYT1L0.933
KCNQ50.932
GABRG20.932
ST8SIA30.932
DGKI0.93

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.554
MYL3-0.549
RAB13-0.549
COPZ2-0.547
FLT3LG-0.539
RNF135-0.534
TFPI2-0.531
FZD10-0.523
EMP3-0.517
SLC43A3-0.516

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GPR12 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GPR12 mRNA"19114083
D000452AldrinAldrin results in increased expression of GPR12 mRNA18579281
D001280AtrazineAtrazine results in decreased expression of GPR12 mRNA25929836
D004958EstradiolEstradiol results in increased expression of GPR12 mRNA20068009
D002994ClofibrateClofibrate results in decreased expression of GPR12 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of GPR12 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of GPR12 mRNA18579281
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GPR12 mRNA28962523
D009532NickelNickel results in decreased expression of GPR12 mRNA25583101
C010272palytoxinpalytoxin results in increased expression of GPR12 mRNA26436198
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of GPR12 mRNA28973697
D011441PropylthiouracilPropylthiouracil results in decreased expression of GPR12 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in decreased expression of GPR12 mRNA21340527
D012999SomanSoman results in decreased expression of GPR12 mRNA19281266
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA"18579281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR12 mRNA26377647
D014635Valproic AcidValproic Acid affects the expression of GPR12 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GPR12 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0031210phosphatidylcholine binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006874cellular calcium ion homeostasis-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-TAS8530049  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal