Gene: PLA2G4D

283748
cPLA2delta
phospholipase A2 group IVD
protein-coding
15q15.1
Ensembl:ENSG00000159337 MIM:612864 Vega:OTTHUMG00000172587 UniprotKB:Q86XP0
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.756e-1 (AD)  3.352e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1668589chr15:42071571 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPHA70.575
DGAT20.573
DRD10.565
DNAH60.563
GPR1550.563
DGKI0.558
OPRK10.556
LMO70.551
SEMA3A0.545
RYR20.544

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.366
CASP12-0.319
ZIC2-0.311
MAPKAPK3-0.309
TMSB15A-0.308
TCF7L1-0.307
NKX6-1-0.293
AJUBA-0.293
ZIC5-0.291
MSX1-0.29

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of PLA2G4D gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLA2G4D mRNA23735875
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of PLA2G4D mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of PLA2G4D mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of PLA2G4D mRNA25181051
D052638Particulate MatterParticulate Matter results in increased expression of PLA2G4D mRNA28341207
D010936Plant ExtractsPlant Extracts results in decreased expression of PLA2G4D mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLA2G4D mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLA2G4D mRNA23152189

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004622lysophospholipase activity-TAS-  
GO:0004623phospholipase A2 activity-IBA21873635  
GO:0004623phospholipase A2 activity-TAS-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO:0008970phosphatidylcholine 1-acylhydrolase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO:0047498calcium-dependent phospholipase A2 activity-IBA21873635  
GO:0047498calcium-dependent phospholipase A2 activity-IDA14709560  
GO:0102567phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)-IEA-  
GO:0102568phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-TAS-  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0036148phosphatidylglycerol acyl-chain remodeling-TAS-  
GO:0036149phosphatidylinositol acyl-chain remodeling-TAS-  
GO:0036150phosphatidylserine acyl-chain remodeling-TAS-  
GO:0036151phosphatidylcholine acyl-chain remodeling-TAS-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO:0046475glycerophospholipid catabolic process-IBA21873635  
GO:0046475glycerophospholipid catabolic process-IDA14709560  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482788Acyl chain remodelling of PCTAS
R-HSA-1482801Acyl chain remodelling of PSTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1482922Acyl chain remodelling of PITAS
R-HSA-1482925Acyl chain remodelling of PGTAS
R-HSA-1483115Hydrolysis of LPCTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal