Gene: GPR15

2838
BOB
G protein-coupled receptor 15
protein-coding
3q11.2
Ensembl:ENSG00000154165 MIM:601166 Vega:OTTHUMG00000160017 UniprotKB:P49685
NC_000003.12
PubMed
0   ANCO-SNPs
ND
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.340e-1 (AD)  4.244e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19859270chr3:98251294GPR151.300e-20Smoking27651444
cg19859270chr3:98251294GPR151.780e-28Tobacco smoking28225026
cg19614811chr3:98250723GPR156.220e-9Tobacco smoking28225026
cg19859270chr3:98251294GPR155.970e-45Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMPRSS20.463
CAMP0.425
MSMB0.397
DUOX20.396
CFTR0.384
PRG30.369
HBEGF0.363
PRAC10.362
CD79A0.361
IFITM50.36

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C16orf47-0.245
NGB-0.229
YBX2-0.222
TMEM221-0.222
FRMPD2-0.216
CTXN3-0.211
PVALB-0.21
NMU-0.208
NEK2-0.207
EIF4E1B-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GPR15 mRNA21298039
C006632arsenic trioxidearsenic trioxide results in increased expression of GPR15 mRNA20458559
C006780bisphenol Abisphenol A results in decreased expression of GPR15 mRNA25181051
C069837fullerene C60fullerene C60 results in decreased expression of GPR15 mRNA19167457
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GPR15 mRNA25613284
C047806monomethylpropionmonomethylpropion results in increased expression of GPR15 mRNA22303338
C028007nickel monoxidenickel monoxide results in decreased expression of GPR15 mRNA19167457
C006253pirinixic acidpirinixic acid results in increased expression of GPR15 mRNA18301758
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GPR15 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of GPR15 gene26756918
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GPR15 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of GPR15 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IDA15650194  
GO:0004930G-protein coupled receptor activity-IDA28900043  28936214  
GO:0005515protein binding-IPI28936214  
GO:0015026coreceptor activity-IDA15650194  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IDA28900043  28936214  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0046718viral entry into host cell-IDA15650194  
GO:0072678T cell migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IDA28615320  
GO:0005886plasma membrane-IDA28615320  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8838812  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29149250Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study. (2017 Nov 15)Jhun MAAm J Epidemiol
29183299Tobacco-smoking induced GPR15-expressing T cells in blood do not indicate pulmonary damage. (2017 Nov 28)Bauer MBMC Pulm Med
26441693Ethnicity and Smoking-Associated DNA Methylation Changes at HIV Co-Receptor GPR15. (2015)Dogan MVFront Psychiatry
24559495The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. (2014 Feb 22)Dogan MVBMC Genomics
27154971The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease. (2016 Sep)Obeidat MNicotine Tob Res
23657504Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans. (2013 Sep)Sun YVHum Genet
28423922Activation of GPR15 and its involvement in the biological effects of smoking. (2017 Jun)Koks SExp Biol Med (Maywood)
25424692Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)Tsaprouni LGEpigenetics
22492999Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. (2012 Jul 1)Wan ESHum Mol Genet
26348578Smoking-induced expression of the GPR15 gene indicates its potential role in chronic inflammatory pathologies. (2015 Nov)Koks GAm J Pathol
28158590A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. (2016 Nov 1)Huan THum Mol Genet
26478754DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. (2015)Gao XClin Epigenetics