Gene: TMEM114

283953
-
transmembrane protein 114
protein-coding
16p13.2
Ensembl:ENSG00000232258 MIM:611579 Vega:OTTHUMG00000172868 UniprotKB:B3SHH9
NG_041767.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.703e-1 (AD)  4.966e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8061765chr16:8540871 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27298570chr16:8623004TMEM1146.200e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMX20.802
FOXB10.802
OTP0.797
HCRT0.79
C22orf420.789
NTS0.783
AVP0.783
LHX50.783
SIM10.779
OXT0.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRELP-0.34
GAL3ST4-0.32
VSIG10-0.31
C2CD2-0.297
OXER1-0.295
MGLL-0.285
PDGFRB-0.283
FGD6-0.281
FOXF2-0.279
PEAR1-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C584509C646 compoundC646 compound results in increased expression of TMEM114 mRNA26191083
D002104CadmiumCadmium results in decreased expression of TMEM114 mRNA24084258
C039281furanfuran results in increased methylation of TMEM114 gene22079235
C492448ICG 001ICG 001 results in increased expression of TMEM114 mRNA26191083
D009532NickelNickel results in decreased expression of TMEM114 mRNA24084258
C570897NSC668394NSC668394 results in increased expression of TMEM114 mRNA27137931
D012834SilverSilver results in increased expression of TMEM114 mRNA27131904

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0016327apicolateral plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal