Gene: TSEN54

283989
PCH2A|PCH4|PCH5|SEN54L|sen54
tRNA splicing endonuclease subunit 54
protein-coding
17q25.1
Ensembl:ENSG00000182173 MIM:608755 Vega:OTTHUMG00000179684 UniprotKB:Q7Z6J9
NG_013041.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.466e-1 (AD)  4.958e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFSWAP0.9
UCKL10.894
CCDC1300.891
TAZ0.883
CLASRP0.881
CXXC10.876
ZNF2760.869
LRCH40.866
PRR140.865
PTDSS20.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.542
OR4F29-0.505
TRDN-0.233
OR4F16-0.186
MTRNR2L9-0.176
CALCR-0.175
PAGE4-0.174
HMHB1-0.17
ALG10B-0.17
CARD17-0.167

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of TSEN54 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TSEN54 mRNA19770486
D001151ArsenicArsenic affects the methylation of TSEN54 gene25304211
D001554BenzeneBenzene results in increased expression of TSEN54 mRNA19162166
C006780bisphenol Abisphenol A affects the expression of TSEN54 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TSEN54 mRNA25181051
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TSEN54 mRNA]27941970
C082360fipronilfipronil results in decreased expression of TSEN54 mRNA23962444
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of TSEN54 mRNA17183730
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TSEN54 mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TSEN54 mRNA"20188158
C028007nickel monoxidenickel monoxide results in increased expression of TSEN54 mRNA19167457
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TSEN54 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of TSEN54 mRNA21334430
D012969Sodium FluorideSodium Fluoride results in increased expression of TSEN54 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSEN54 mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of TSEN54 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TSEN54 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of TSEN54 mRNA28973375
C012589trichostatin Atrichostatin A results in increased expression of TSEN54 mRNA15901671
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of TSEN54 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of TSEN54 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TSEN54 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TSEN54 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000213tRNA-intron endonuclease activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000379tRNA-type intron splice site recognition and cleavage-IBA21873635  
GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation-IDA17495927  
GO:0006397mRNA processing-IEA-  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000214tRNA-intron endonuclease complex-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6784531tRNA processing in the nucleusTAS
R-HSA-72306tRNA processingTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med