Gene: KANSL1

284058
CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1
KAT8 regulatory NSL complex subunit 1
protein-coding
17q21.31
Ensembl:ENSG00000120071 MIM:612452 Vega:OTTHUMG00000178026 UniprotKB:Q7Z3B3
NG_032784.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  5.738e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF3840.922
NCOA60.911
RPRD20.91
TADA2B0.91
KDM2A0.909
RERE0.909
SEC24C0.908
RNF2160.908
ZFYVE10.907
SMG70.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.646
OR4F29-0.611
KLRB1-0.304
KLRC2-0.295
TFPI2-0.283
KLRF1-0.272
NANOGNB-0.261
GZMK-0.258
CD3D-0.252
CD8B-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KANSL1 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of KANSL1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KANSL1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KANSL1 mRNA24449571
D001151ArsenicArsenic affects the methylation of KANSL1 gene25304211
D004041Dietary FatsDietary Fats results in decreased expression of KANSL1 mRNA25016146
D005472FluorouracilKANSL1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
C051890irinotecanKANSL1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KANSL1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of KANSL1 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of KANSL1 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KANSL1 mRNA25729387
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of KANSL1 mRNA28903501
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of KANSL1 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KANSL1 mRNA17101203
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KANSL1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of KANSL1 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of KANSL1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of KANSL1 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of KANSL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KANSL1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of KANSL1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15960975  16189514  21516116  24788516  25416956  27705803  
GO:0035035histone acetyltransferase binding-IBA21873635  
GO:0043995histone acetyltransferase activity (H4-K5 specific)CONTRIBUTES_TOIBA21873635  
GO:0043995histone acetyltransferase activity (H4-K5 specific)contributes_toIDA20018852  
GO:0043996histone acetyltransferase activity (H4-K8 specific)CONTRIBUTES_TOIBA21873635  
GO:0043996histone acetyltransferase activity (H4-K8 specific)contributes_toIDA20018852  
GO:0046972histone acetyltransferase activity (H4-K16 specific)CONTRIBUTES_TOIBA21873635  
GO:0046972histone acetyltransferase activity (H4-K16 specific)contributes_toIDA20018852  
GO ID GO Term Qualifier Evidence PubMed
GO:0043981histone H4-K5 acetylation-IDA20018852  
GO:0043982histone H4-K8 acetylation-IDA20018852  
GO:0043984histone H4-K16 acetylation-IDA20018852  
GO ID GO Term Qualifier Evidence PubMed
GO:0000123histone acetyltransferase complex-IDA20018852  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0044545NSL complex-IBA21873635  
GO:0071339MLL1 complex-IDA15960975  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214847HATs acetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med