Gene: GSDMA

284110
FKSG9|GSDM|GSDM1
gasdermin A
protein-coding
17q21.1
Ensembl:ENSG00000167914 MIM:611218 Vega:OTTHUMG00000179522 UniprotKB:Q96QA5
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.428e-1 (AD)  6.802e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GADL10.862
MROH50.846
SULT1E10.837
DPPA40.836
FER1L60.799
UBL4B0.792
COL15A10.791
FCER20.787
ALX30.786
RNF170.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.534
DBP-0.5
FUT9-0.489
HDAC11-0.484
TM7SF2-0.482
HHATL-0.478
BDH1-0.475
KLHL26-0.469
PLA2G6-0.468
SLC1A4-0.463

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of GSDMA mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of GSDMA mRNA17562736
D001104ArbutinArbutin results in decreased expression of GSDMA mRNA17103032
C006632arsenic trioxidearsenic trioxide results in increased expression of GSDMA mRNA20458559
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of GSDMA mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GSDMA mRNA25181051
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GSDMA mRNA23640034
C011890kojic acidkojic acid results in decreased expression of GSDMA mRNA16595896
D009538NicotineNicotine results in increased expression of GSDMA mRNA23825647
C570897NSC668394NSC668394 results in increased expression of GSDMA mRNA27137931
D052638Particulate MatterParticulate Matter results in increased expression of GSDMA mRNA28341207
D011192Potassium DichromatePotassium Dichromate results in increased expression of GSDMA mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of GSDMA mRNA24780913
D013605T-2 ToxinT-2 Toxin results in decreased expression of GSDMA mRNA26141394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of GSDMA mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSDMA mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSDMA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSDMA mRNA22298810
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GSDMA gene27618143

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IBA21873635  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IBA21873635  
GO:0070273phosphatidylinositol-4-phosphate binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IDA17471240  
GO:0042742defense response to bacterium-IBA21873635  
GO:0070269pyroptosis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA17471240  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2262659217q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. (2012 Jun)Marinho SAnn Allergy Asthma Immunol
2362200517q12-21 and asthma: interactions with early-life environmental exposures. (2013 May)Blekic MAnn Allergy Asthma Immunol