Gene: ZIK1

284307
ZNF762
zinc finger protein interacting with K protein 1
protein-coding
19q13.43
Ensembl:ENSG00000171649 Vega:OTTHUMG00000183468 UniprotKB:Q3SY52
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.101e-2 (AD)  4.908e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17798563chr19:58094517ZIK13.770e-8Maternal smoking in pregnancy27040690
cg17798563chr19:58094517ZIK13.530e-11Maternal smoking in pregnancy27040690
cg17798563chr19:58094517ZIK18.090e-10Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA140.839
ZMYM60.819
NPAT0.816
FASTKD30.815
EDEM10.81
DIS30.81
THUMPD10.81
CEP570.808
NHLRC30.807
TUBGCP30.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.396
OR4F29-0.364
PLA2G5-0.261
MTRNR2L9-0.255
NKX6-1-0.254
ADAMTSL5-0.251
HMGB4-0.233
HIGD1B-0.233
MTRNR2L6-0.22
NXNL1-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZIK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZIK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZIK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZIK1 mRNA"27188386
C015001arsenitearsenite results in decreased expression of ZIK1 mRNA23974009
C015001arsenitearsenite results in increased methylation of ZIK1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of ZIK1 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of ZIK1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ZIK1 mRNA20938992
D002945CisplatinCisplatin results in increased expression of ZIK1 mRNA27594783
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ZIK1 mRNA20938992
D007854LeadLead affects the expression of ZIK1 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ZIK1 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ZIK1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] affects the expression of ZIK1 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ZIK1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZIK1 mRNA23649840
C523799MRK 003ZIK1 results in decreased susceptibility to MRK 00319903844
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZIK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ZIK1 mRNA26272509
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ZIK1 mRNA19073995
D012906SmokeSmoke results in increased expression of ZIK1 mRNA21095227
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ZIK1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] affects the expression of ZIK1 mRNA26378955
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ZIK1 mRNA28065790
C024746tobacco tartobacco tar results in decreased expression of ZIK1 mRNA19559774
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZIK1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ZIK1 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of ZIK1 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer