Gene: HKR1

284459
ZNF875
HKR1, GLI-Kruppel zinc finger family member
protein-coding
19q13.12
Ensembl:ENSG00000181666 MIM:165250 Vega:OTTHUMG00000181937 UniprotKB:P10072
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.055e-1 (AD)  6.985e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERCC30.95
HDAC30.947
SUPT7L0.946
STRADA0.941
GTF3C20.937
CDK5RAP10.936
QRICH10.936
ACAD80.935
TCERG10.93
GIT20.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.629
OR4F29-0.588
MTRNR2L6-0.334
MTRNR2L9-0.33
KLRC2-0.296
MTRNR2L10-0.295
KLRB1-0.26
C8orf74-0.259
TRDN-0.253
NKX6-1-0.251

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of HKR1 mRNA"20453058
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HKR1 gene27153756
D001151ArsenicArsenic results in increased methylation of HKR1 promoter21291286
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HKR1 mRNA28628672
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HKR1 mRNA28628672
D000069286BortezomibBortezomib results in increased expression of HKR1 mRNA20977926
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HKR1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HKR1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HKR1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HKR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HKR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HKR1 mRNA28628672
D011794QuercetinQuercetin results in increased expression of HKR1 mRNA21632981
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HKR1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of HKR1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HKR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HKR1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of HKR1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS2850480  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-NAS2850480  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26203295Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)Maccani JZAdv Genomics Genet