Gene: RSPO1

284654
CRISTIN3|RSPO
R-spondin 1
protein-coding
1p34.3
Ensembl:ENSG00000169218 MIM:609595 Vega:OTTHUMG00000004321 UniprotKB:Q2MKA7
NG_012239.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.306e-2 (AD)  1.407e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L100.751
MTRNR2L90.687
MTRNR2L30.683
MTRNR2L60.677
TTLL10-AS10.635
KRT160.633
KRT70.623
SCNN1B0.612
CXCL170.601
FOXE10.59

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NKPD1-0.421
IKBKG-0.413
CPEB1-0.399
SPATA4-0.394
CNGA4-0.388
KLHL28-0.387
CEP72-0.386
MICU3-0.382
PABPC1L2B-0.377
CBX8-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of RSPO1 mRNA"26377693
D020106AcrylamideAcrylamide results in decreased expression of RSPO1 mRNA28959563
D004958EstradiolEstradiol results in increased expression of RSPO1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of RSPO1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RSPO1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of RSPO1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RSPO1 mRNA22079614
D003976DiazinonDiazinon results in increased methylation of RSPO1 gene22964155
D004041Dietary FatsDietary Fats results in decreased expression of RSPO1 mRNA25016146
C069837fullerene C60fullerene C60 results in decreased expression of RSPO1 mRNA19167457
C039281furanfuran results in increased expression of RSPO1 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of RSPO1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of RSPO1 mRNA28973697
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RSPO1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RSPO1 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of RSPO1 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of RSPO1 mRNA19167457
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of RSPO1 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of RSPO1 mRNA24205000
D010634PhenobarbitalPhenobarbital results in decreased expression of RSPO1 mRNA19084549
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of RSPO1 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of RSPO1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of RSPO1 mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of RSPO1 mRNA29191790
C009277sodium arsenatesodium arsenate results in decreased expression of RSPO1 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RSPO1 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RSPO1 mRNA26377647
C009495titanium dioxidetitanium dioxide results in increased expression of RSPO1 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RSPO1 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of RSPO1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of RSPO1 mRNA17292431|1796380

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI21727895  
GO:0005102signaling receptor binding-IPI22615920  
GO:0005109frizzled binding-IBA21873635  
GO:0005515protein binding-IPI17804805  22575959  22815884  23891289  24165923  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IDA22615920  
GO:0002090regulation of receptor internalization-IDA17804805  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-IDA22575959  
GO:0030177positive regulation of Wnt signaling pathway-NAS24431302  
GO:0048856anatomical structure development-IBA21873635  
GO:0090263positive regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA17804805  22815884  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS24431302  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29162857Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads. (2017 Nov 21)Mamsen LSSci Rep